Tuberculous meningitis in HIV-infected patients in Brazil: clinical and laboratory characteristics and factors associated with mortality

Croda, Mariana Garcia; Vidal, José E.; Hernández, Adrian V.; Molin, Tiago Dal; Gualberto, Felipe Augusto Souza; Oliveira, Augusto César Penalva de

doi:10.1016/j.ijid.2009.08.012

Cited by 33 publications

(31 citation statements)

References 27 publications

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“…The reports about the characteristic of cerebrospinal fluid cytology (CSFC) in TBM patients were not consistent. [9][10][11][12][13] Some scholars believe a lymphocyte predominance is the typical feature of TBM, while others think the increasing number of neutrophils is the characteristics of TBM. In our study, there were 54% (27 of 50) patients' CSF showed neutrophil predominance (>50%) in TBM group.…”

Section: Discussionmentioning

confidence: 99%

Prediction of cerebrospinal fluid parameters for tuberculous meningitis

Zou

Guo

et al. 2015

Diagnostic Cytopathology

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Section: Discussionmentioning

confidence: 99%

Prediction of cerebrospinal fluid parameters for tuberculous meningitis

Zou

Guo

et al. 2015

Diagnostic Cytopathology

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“…20 Our low CSF culture yield may reflect antituberculous treatment or the difficulty of culturing Mycobacterium tuberculosis from the CSF especially with HIV co-infection. [21][22][23][24] Direct contiguous spread from infected cervical, mediastinal, or retroperitoneal lymph nodes may provide another route for spinal infection in the absence of bony involvement. This was convincingly demonstrated in only 2 of our cases.…”

Section: Reviewed the Mri Of 55 Hiv-positive European Andmentioning

confidence: 99%

Acute Myelopathy or Cauda Equina Syndrome in HIV-Positive Adults in a Tuberculosis Endemic Setting: MRI, Clinical, and Pathologic Findings

Candy

Chang

Andronikou

2014

American Journal of Neuroradiology

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BACKGROUND AND PURPOSE:Cape Town is the center of an HIV-tuberculosis coepidemic. This study's aim was to highlight the importance and to describe the MR imaging features of tuberculosis in acute myelopathy and cauda equina syndrome in HIV-positive adults. To accomplish this we retrospectively reviewed the MR imaging and clinico-pathologic findings of HIV-positive patients presenting to our hospital with recent onset paraplegia and sphincter dysfunction over a 4-year period, 2008 -2011.

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“…Like HIV-1 uninfected patients, HIV-1 infected patients can present with a range of neurological manifestations: tuberculous meningitis (TBM), tuberculomas, radiculomyelitis and tuberculous brain abscess [39]. In patients with TB, meningeal involvement is more common in HIV-1-infected patients [40,41].…”

Section: Asymptomatic Active Pulmonary Tbmentioning

confidence: 99%

Clinical management of tuberculosis and HIV-1 co-infection

Schutz¹,

Meintjes²,

Almajid³

et al. 2010

Eur Respir J

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In many parts of the world the commonest serious opportunistic infection that occurs in HIV-1 infected persons is tuberculosis (TB). HIV-1 co-infection modifies the natural history and clinical presentation, and adversely affects the outcome of TB. Severe disseminated disease is well-recognised but it is increasingly appreciated that early disease characterised by very few or no symptoms is also common. Immunodiagnostic methods to ascertain latent TB in HIV-1 infected persons are compromised in sensitivity.Chemoprevention of HIV-1-associated TB is effective, its benefits are restricted to those which have evidence of immune sensitisation and appear short-lived in areas of high TB burden. Although promising advances in the microbiological diagnosis of TB have recently occurred, the diagnosis of HIV-1-associated TB remains difficult because of more frequent presentation as sputum negative or extrapulmonary disease.Management of co-infected patients can be complex because of overlapping drug toxicities and interactions. Nevertheless consensus is developing that antiretroviral therapy should be provided as soon as practicable after starting TB treatment in HIV-1 co-infected persons. This has the consequence of increasing the frequency of immune reconstitution inflammatory syndrome, the pathogenesis and management of which is poorly defined.

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Tuberculous meningitis in HIV-infected patients in Brazil: clinical and laboratory characteristics and factors associated with mortality

Abstract: Clinical and laboratory manifestations were unspecific. Disseminated tuberculosis and severe immunosuppression were common. Mortality was high and the 9-month survival rate was low. Tachycardia and prior HAART were associated with death within 9 months of diagnosis.

Cited by 33 publications

References 27 publications

Prediction of cerebrospinal fluid parameters for tuberculous meningitis

Prediction of cerebrospinal fluid parameters for tuberculous meningitis

Acute Myelopathy or Cauda Equina Syndrome in HIV-Positive Adults in a Tuberculosis Endemic Setting: MRI, Clinical, and Pathologic Findings

Clinical management of tuberculosis and HIV-1 co-infection

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