Tuberculous Pseudoaneurysms of the Thoracic Aorta

Abstract

A 16-year-old girl from an area in Brazil where tuberculosis was endemic was admitted because of recurrent chest pain, progressive dyspnea with exertion, and inability to climb more than 1 flight of stairs. She described fatigue, weight loss, night sweats, and adenopathy of her right axilla and neck during the previous 3 months. On admission she looked distressed, with a heart rate of 76 bpm and blood pressure of 110/55 mm Hg. The ECG demonstrated sinus rhythm with first-degree heart block ( Figure 1).Her admission chest radiograph demonstrated cardiomegaly with pulmonary edema (Figure 2). Her cardiac enzymes were negative. The patient underwent cardiac evaluation with 2-dimensional echocardiography (not shown), which revealed an interatrial septal mass, mild tricuspid regurgitation, preserved systolic function, and moderate pericardial effusion.For further characterization of the mass, cardiovascular magnetic resonance imaging (MRI) was performed. Coronal black-blood T2-Turbo Spin Echo and T2-Short T1/Tau Inversion Recovery images of the chest showed adenopathy of the right axilla and a multicystic mass located on the posterior mediastinum (Figure 3). Four-chamber view cine-MRI demonstrated mitral and tricuspid regurgitation, pericardial effusion, and an interatrial septum mass (Figure 4A and 4B). A large retrocardiac pulsatile lesion involving the distal thoracic aorta was also noted (Figure 4 and Movie I of the online-only Data Supplement). Delayed-enhancement MRI confirmed the rounded interatrial septal mass with no evidence of enhancement, consistent with a hematoma of the interatrial septum ( Figure 4C), possibly secondary to a leaking aortic root pseudoaneurysm ( Figure 5B and Movie II of the online-only Data Supplement).Time-resolved contrast-enhanced 3-dimensional magnetic resonance angiography demonstrated multiple pseudoaneurysms extensively distributed throughout the ascending and descending thoracic aorta. Longitudinal aorta and 4-chamber views further depicted partially thrombosed pseudoaneurysms, extensive thickening, and late enhancement of the thoracic aortic wall ( Figures 4C and 5), indicating a likely inflammatory cause.Excisional biopsy of her palpable cervical node was performed after her purified protein derivative test proved to be highly reactive (18 mm). The biopsy results demonstrated caseous and noncaseous necrotizing granulomas with positive culture for acid-fast bacilli ( Figure 6).The patient was given an antitubercular 4-medication regimen. Planned surgical intervention decision was precluded when the patient experienced sudden hypovolemic

Thoracic endovascular aortic repair for aortobronchial fistula: a case series

“…Various authors have reported atherosclerosis, previous aortic surgery, and mycotic aneurysm as the common aetiology of ABF, 1 , 2 , 6 , 7 while tuberculosis is a rare cause for it. 5 Previous aortic surgery is a common risk factor for pseudoaneurysm formation. It usually occurs at the suture line or at the cannulation site due to iatrogenic defects in the vessel wall and subsequent poor healing.…”

“… 1–4 Tuberculosis related arteritis and pseudoaneurysm is a rare cause of ABF. 5 Massive haemoptysis and exsanguination following its rupture in lung parenchyma can result in acute respiratory distress, hypotension, and death if an emergency intervention is not performed. An endovascular stent-graft repair of the ruptured aorta can be an alternative to conventional surgery, which otherwise carries high morbidity and mortality.…”

Miliary tuberculosis in a patient with tuberculous mycotic aneurysm of the abdominal aorta: Case report and review of the literature

“…A review of the English literature from 2008 to today revealed 28 more cases (Table 1) [3], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], specifically 18 men and 10 women with a mean age of 44.64 ± 18.16 years (range 16–84). 7 patients had a history of pulmonary tuberculosis and had previously received anti-tuberculosis medication.…”