Tuberkuloseutbrudd på Østlandet

Arnesen, Trude Margrete; Seterelv, Siri; Norheim, Gunnstein; Helgebostad, Sigrid R; Mannsåker, Turid; Ly, Ingvild Nesthus; Rønning, Else Johanne; Steen, Tore W.

doi:10.4045/tidsskr.14.0770

Cited by 5 publications

(1 citation statement)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Currently, close monitoring of intimate contact persons is recommended but inquisition about a sexual relationship may refine the focus on individuals at risk [10]. In keeping with a recent Norwegian study [16], our analyses support a tracking strategy involving core family members first and farther contact persons second, complementing current algorithms based mainly on proximity and cumulative exposure time [10, 17]. Despite the poor predictive value of a positive IGRA test for the development of active tuberculosis, core contact persons may require a close follow-up [8].…”

Section: Discussionmentioning

confidence: 96%

Risk for latent and active tuberculosis in Germany

et al. 2016

View full text Add to dashboard Cite

PurposeFew individuals that are latently infected with M. tuberculosis latent tuberculosis infection(LTBI) progress to active disease. We investigated risk factors for LTBI and active pulmonary tuberculosis (PTB) in Germany.MethodsHealthy household contacts (HHCs), health care workers (HCWs) exposed to M. tuberculosis and PTB patients were recruited at 18 German centres. Interferon-γ release assay (IGRA) testing was performed. LTBI risk factors were evaluated by comparing IGRA-positive with IGRA-negative contacts. Risk factors for tuberculosis were evaluated by comparing PTB patients with HHCs.ResultsFrom 2008–2014, 603 HHCs, 295 HCWs and 856 PTBs were recruited. LTBI was found in 34.5% of HHCs and in 38.9% of HCWs. In HCWs, care for coughing patients (p = 0.02) and longstanding nursing occupation (p = 0.04) were associated with LTBI. In HHCs, predictors for LTBI were a diseased partner (odds ratio 4.39), sexual contact to a diseased partner and substance dependency (all p < 0.001). PTB was associated with male sex, low body weight (p < 0.0001), alcoholism (15.0 vs 5.9%; p < 0.0001), glucocorticoid therapy (7.2 vs 2.0%; p = 0.004) and diabetes (7.8 vs. 4.0%; p = 0.04). No contact developed active tuberculosis within 2 years follow-up.ConclusionsPositive IGRA responses are frequent among exposed HHCs and HCWs in Germany and are poor predictors for the development of active tuberculosis.Electronic supplementary materialThe online version of this article (doi:10.1007/s15010-016-0963-2) contains supplementary material, which is available to authorized users.

show abstract