Tubular Aggregates in Endoplasmic Reticulum in Herpes-Simplex Encephalitis

Baringer,

doi:10.1056/nejm197110212851704

Cited by 66 publications

(21 citation statements)

References 23 publications

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“…The aggregates of tubular structures within dilatated cisternae of the ER in endothelial cells of glomerular and peritubular capillaries found in the present case correspond in their general appearance, localization, and size to those described in different organs and tissues by many other authors [G yorkey et al, 1969, 1972P incus et al, 1970;Baringer. 1971; B aringer and Sw oveland, 1972; U zman Kaiserling, 1972], A great number of reports with regard to these tubules concern systemic lupus erythematosus (SLE) and lupus nephritis (LN) [Gyorkey et al, 1972], In this disease tubular structures have been described within cisternae of the ER in endothelial cells from glomerular and cutaneous vessels both in the spontaneous [Gyorkey et al, 1969[Gyorkey et al, , 1972H ashimoto and Chandler, 1972;N ieland et al, 1972] and in the drug-induced form [T hoenes et al, 1972). Focal and segmental glomerular lesions are con sidered to be typical for LN.…”

Section: Discussionsupporting

confidence: 89%

Intracisternal Branching Tubular Structures (So-Called Myxo-Virus-Like Inclusions) in Endothelial Cells of Kidney

Schürch

Fukuda

1974

Pathobiology

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In a case of discrete focal and segmental glomerulonephritis, branching tubular structures were observed within dilatated cisternae of the endoplasmic reticulum (ER) of endothelial cells from glomerular and peritubular capillaries. These structures were previously described in a variety of nephropathies, especially in lupus nephritis, in several neoplasms, and in a number of viral infections. Some authors considered them as viral or virus-like and others as nonviral in nature. The present observation indicates that the tubules originate from the ER as invaginations, and that they represent proliferated ER membranes rather than viral particles.

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Section: Discussionsupporting

confidence: 89%

Intracisternal Branching Tubular Structures (So-Called Myxo-Virus-Like Inclusions) in Endothelial Cells of Kidney

Schürch

Fukuda

1974

Pathobiology

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“…ciated with a number of virus infections including herpes simplex encephalitis (9) and coxsackie virus myocarditis (6) of man and a wide spectrum of viral infections in animals (13). The possibility that the presence of these structures in connective tissue diseases is a result of specific or nonspecific virus infections (13) requires continued investigation.…”

Section: Referencesmentioning

confidence: 99%

Tubular structures in endothelium in palindromic rheumatism

Molnar

Metzger

McCarty

1972

Arthritis & Rheumatism

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Electron microscopy of synovial tissue in a patient with palindromic rheumatism showed tubular structures in the endothelial cells similar to those reported by others in the tissues of patients with other rheumatic diseases, neoplasms, infections and a variety of other idiopathic conditions.Recurrent attacks of joint pain and swelling, normal blood tests and negative radiographic findings are characteristic of palindromic rheumatism, according to Hench and Rosenberg (1). As about half the patients with palindromic rheumatism eventually develop a positive test for rheumatoid factors, and as some develop rheumatoid arthritis within a few years, many rheumatologists believe that palindromic rheumatism is an atypical form of rheumatoid arthritis (2).The present report describes the findings of tubular lesions in the endothelium of a synovial biopsy of a patient with palindromic rheumatism which was taken at the time of a recurrent attack. HM, Merritt Billings Hospital of the University of Chicago on July 28, 1969 because of severe pain and swelling of the right wrist of 2 days' duration. He had first noted sudden onset of acute arthritis in the left wrist in November 1968, promptly relieved by phenylbutazone prescribed by his family physician 3 days after onset. Thereafter, similar acute attacks, lasting 2 to 4 days, occurred every few weeks, involving a knee, wrist or the smallJoints of hands and feet. Between attacks, the affected areas were free of symptoms and functioned normally. CASE REPORTExamination revealed a well-nourished man in pain. Vital signs were normal. The right wrist showed tenderness, swelling and local warmth without erythema. The grip strength in the left hand, measured in a standard manner with a rolled up blood pressure cuff (3), was 300 mm Hg; it was absent in the right hand (20 mm Hg).Arthrocentesis of the right wrist yielded 1 rnl of inflammatory (Group 11) h i d with 22,500 leukocytes/cu mm; 32% were polymorphonuclear leukocytes, 57% monocytes and 11% lymphocytes. No crystals were seen by phasepolarized light microscopy (4). Joint fluid hemolytic complement was 20 units. Contemporaneous serum hemolytic complement was 250 units (normal: 180-330). Rheumatoid factors were not found in the serum by sensitized sheep cell or latex fixation tests. A C-reactive protein test was negative, and the Westergren erythrocyte sedimentation rate was 13 mm/hr. Antinuclear antibodies were not found by immunofluorescence. Serologic tests for syphilis and tests for anti-DNA antibody were negative. Peripheral blood total and differential leukocyte counts, serum calcium, phosphorus, creatinine and uric acid were within normal limits. An electrocardiogram and roentgenograms of the wrists, elbows, ankles, knees and hands were normal.The wrist was splinted and pain controlled with analgesics during the period of study. On July 25, 1969 a sample of synovium from the right wrist was obtained by open biopsy. Postoperatively he was treated with phenylbutazone, 100 mg every 6 hours; wrist inflammation subsided promptl...

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“…Evidence reviewed elsewhere (25) suggests that they may represent a cellular reaction to virus infection. Structures indistinguishable from the T R S in SLE were reported by Baringer (27) in the brain of a patient with herpetic encephalitis as well as the brains of rabbits infected experimentally with herpes simplex virus. Tubuloreticular structures were also identified in a case of coxsackie myocarditis (28) and in congenital rubella (8).…”

Section: Nature and Pathogenesis Of Trsmentioning

confidence: 59%

Abnormal Structures in Circulating Lymphocytes from Patients with Systemic Lupus Erythematosus and Related Diseases

Grimley

Decker

Michelitch

et al. 1973

Arthritis & Rheumatism

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A prospective electron microscopic study, incorporating blind controls, demonstrated tubuloreticular structures (TRS) in the buffy coat lymphocytes of 32 patients with connective tissue disease. From 1 to 8% of the lymphocyte sections were involved. The abnormal structures consisted of interwoven, electron-dense tubules (220 to 280 A diameter) which were located within the endoplasmic reticulum. Tubuloreticular structures were found in lymphocytes from 20 of 30 patients with systemic lupus erythematosus (SLE), 2 of 4 with discoid lupus erythematosus, 8 of 20 with other connective tissue disease and none of 22 control cases. Clinical evaluation of the patients with SLE disclosed no specific differences between those with TRS-positive or TRS-negative lymphocytes; there were some indications of greater disease activity in the TRS-positive group. The biologic nature of TRS is unknown, but they have been linked to virus infection under both clinical and experimental conditions. systemic lupus erythematosus (SLE) (3-6) and many patients with related diseases of connective tissues (7-9). We now report a significant frequency of morphologically identical structures in the circulating lymphocytes of such patients.T h e tubules in question have been distinguished by their ultrastructural appearance. They are relatively electron-dense and measure in the range of 220 to 280 A in diameter. They are interwoven within membrane-limited compartments which can often be identified as dilatations of the endoplasmic reticulum or perinuclear space. T h e biologic nature of these structures is still unknown, and we have adopted the description tu buloreticular struclures (TRS) also proposed by Dalton (1 0).T h e possibility of finding T R S in circulating cells was suggested by electron microscopic examination of a skin biopsy from a 24-year-old man with SLE with subcutaneous nodules and histologic evidence of chronic vasculitis. Thin

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Tubular Aggregates in Endoplasmic Reticulum in Herpes-Simplex Encephalitis

Cited by 66 publications

References 23 publications

Intracisternal Branching Tubular Structures (So-Called Myxo-Virus-Like Inclusions) in Endothelial Cells of Kidney

Intracisternal Branching Tubular Structures (So-Called Myxo-Virus-Like Inclusions) in Endothelial Cells of Kidney

Tubular structures in endothelium in palindromic rheumatism

Abnormal Structures in Circulating Lymphocytes from Patients with Systemic Lupus Erythematosus and Related Diseases

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