Tubular Carcinoma of the Breast: Immunohistochemical and DNA Flow Cytometric Profile

Fasano, Maria Edvige; Vamvakas, Eleftherios C.; Delgado, Yara; Inghirami, Giorgio; Mitnick, J S; Roses, Daniel F.; Feiner, Helen

doi:10.1046/j.1524-4741.1999.98103.x

Cited by 10 publications

(8 citation statements)

References 14 publications

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“…However, patients with TC had a greater number of favorable prognostic factors than those with DCIS, such as a lower NG, higher ER/PR expression, and lower HER2 overexpression. Specifically, high rates of hormone receptor positivity, HER2 negativity, and lower NG were also reported in several other studies [3,25]. However, patients with TC showed a significantly higher rate of LN metastasis than those with DCIS.…”

Section: Discussionsupporting

confidence: 72%

Tubular Carcinoma of the Breast: Clinicopathologic Features and Survival Outcome Compared with Ductal CarcinomaIn Situ

et al. 2013

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PurposeTubular carcinoma (TC) of the breast is an uncommon histological subtype of invasive breast cancer with an excellent prognosis compared with standard invasive ductal carcinoma. Recent studies suggested a possible precursor role for low grade ductal carcinoma in situ (DCIS) in the development of TC. The goal of this analysis was to understand the clinicopathologic features and outcomes of TC by comparing TC with DCIS.MethodsA retrospective review identified 70 patients with TC and 1,106 patients with DCIS between 1995 and 2011. Student t-test and Fisher exact test were used to compare the clinicopathologic characteristics of TC patients with those of DCIS patients. The Kaplan-Meier method and Cox regression analysis were used to determine disease-free survival (DFS) rates.ResultsCompared to DCIS, TC exhibited favorable clinicopathologic characteristics such as a lower nuclear grade (92.3%), higher expression of hormonal receptors (estrogen receptor-positive, 92.9%; progesterone receptor-positive, 87.0%), and less frequent overexpression of human epidermal growth receptor 2 (12.9%). DFS did not differ significantly between the TC and DCIS groups (5-year DFS, 100% vs. 96.7%; 10-year DFS, 92.3% vs. 93.3%; p=0.324), and cancer-specific deaths were not noted in either group. However, axillary lymph node involvement was observed in six (8.6%) of the 70 patients with TC. Three of these patients had small tumors (≤1 cm).ConclusionIn our study cohort, TC was associated with an excellent prognosis and a low rate of lymph node metastasis. However, lymph nodes metastases were found even in patients with small tumors (≤1 cm). Axillary staging must be considered for all patients with TC of the breast.

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Section: Discussionsupporting

confidence: 72%

Tubular Carcinoma of the Breast: Clinicopathologic Features and Survival Outcome Compared with Ductal CarcinomaIn Situ

et al. 2013

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“…Even though nearly half of these tubular carcinomas were node‐positive, the majority were low‐grade and oestrogen receptor‐positive, and these factors were as frequently present in node‐positive as in node‐negative cases. Other authors have noted that a higher proportion of cases with tubular carcinoma are oestrogen receptor positive compared to those without tubular histology 3,15,16 . This fact may contribute to the more favourable response to adjuvant treatment obtained for these patients.…”

Section: Discussionmentioning

confidence: 95%

Tubular carcinoma of the breast: Prognosis and response to adjuvant systemic therapy

Kitchen

Smith

Henderson

et al. 2001

ANZ Journal of Surgery

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“…Furthermore, DNA ploidy has been reported to be correlated with other biological factors such as the tumor grade [10,11], mitotic index [9] and c-erbB2 [19,20]. There have been various studies in which multiple biological parameters, including DNA ploidy, have been analyzed by multivariate analyses as potential prognostic factors in breast cancer [23][24][25][26][27][28]. In these studies, however, there were few analyses of the relationship between DNA ploidy and the combination of multiple biological parameters in breast cancer.…”

Section: Discussionmentioning

confidence: 99%

DNA Aneuploidy in Relation to the Combination of Analysis of Estrogen Receptor, Progesterone Receptor, p53 Protein and Epidermal Growth Factor Receptor in 498 Breast Cancers

et al. 2002

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Background: Various studies have analyzed the relationships between new biological parameters and DNA ploidy for human cancer. However, the biological significance of DNA ploidy remains unclear, since there have so far been few studies analyzing DNA ploidy in relation to the combination of multiple such biological parameters. Methods: Samples for the analysis of DNA ploidy, estrogen receptor (ER), progesterone receptor (PgR), p53 protein and epidermal growth factor receptor (EGFR) were prepared from the same frozen specimens of 498 primary breast cancers. DNA ploidy was determined by flow cytometry, while ER and PgR were determined by an enzyme immunoassay. Both p53 protein and EGFR were determined by immunohistochemical analyses. Results: Aneuploidy was significantly correlated with the absence of ER, the absence of PgR, the positivity of p53 protein and the positivity of EGFR, and it was also significantly correlated with the combination of the absence of ER and PgR and the combination of the positivity of p53 protein and EGFR. A deviation in the four parameters was defined as the absence of ER, the absence of PgR, the positivity of p53 protein or the positivity of EGFR. As the number of deviations of these four biological parameters increased, the incidence of aneuploidy increased significantly (p < 0.0001). Multivariate analysis also indicated that deviation of two, three or all four parameters were significant factors for DNA ploidy, while the p value decreased and the odds ratio increased as the number of deviations of the four biological parameters increased. Conclusions: DNA aneuploidy based on flow cytometric analysis reflects the accumulation of deviations in the four biological parameters investigated in the present study. The two facts that DNA aneuploidy reflects the accumulation of the aggressiveness of these biological parameters and that DNA aneuploidy consisted of heterogeneous characteristics which were represented by the deviation of each biological parameter should be taken into consideration when selecting treatment strategies for breast cancer.

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Tubular Carcinoma of the Breast: Immunohistochemical and DNA Flow Cytometric Profile

Cited by 10 publications

References 14 publications

Tubular Carcinoma of the Breast: Clinicopathologic Features and Survival Outcome Compared with Ductal CarcinomaIn Situ

Tubular Carcinoma of the Breast: Clinicopathologic Features and Survival Outcome Compared with Ductal CarcinomaIn Situ

Tubular carcinoma of the breast: Prognosis and response to adjuvant systemic therapy

DNA Aneuploidy in Relation to the Combination of Analysis of Estrogen Receptor, Progesterone Receptor, p53 Protein and Epidermal Growth Factor Receptor in 498 Breast Cancers

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