Tubular networks in soleus muscle fibers of the rat following tenotomy. I. Spatial organization

Andreev, D.; Wassilev, W

doi:10.1016/s0940-9602(11)80422-x

Cited by 2 publications

(1 citation statement)

References 11 publications

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“…Several muscular and neuromuscular diseases are associated with periodic membrane transformation of t-tubules of striated muscles, usually referred to as honeycomb structures. T-tubular morphological membrane transformation has been described in denervated muscles (Gori, 1972;Madarame et al, 1986;Miledi and Slater, 1969;Pellegrino and Franzini, 1963), in the muscles with induced experimental myopathy , bupivacaine-induced myonecrosis (Huxley and Taylor, 1958), and in tenotomized muscles of the rat (Andreev and Wassilev, 1994). They have also been observed in various human muscles as a consequence of muscular diseases (Borg et al, 1989;Cornog and Gonatas, 1967;Engel and Dale, 1968;Engel and Macdonald, 1970;Gori, 1972;Iorio Di et al, 1989;Miike et al, 1984).…”

Section: Muscular Dystrophymentioning

confidence: 99%

Chapter 6 Cubic Membranes

Almsherqi

Landh

Kohlwein

et al. 2009

International Review of Cell and Molecular Biology

131

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Biological membranes are among the most fascinating assemblies of biomolecules: a bilayer less than 10 nm thick, composed of rather small lipid molecules that are held together simply by noncovalent forces, defines the cell and discriminates between "inside" and "outside", survival, and death. Intracellular compartmentalization-governed by biomembranes as well-is a characteristic feature of eukaryotic cells, which allows them to fulfill multiple and highly specialized anabolic and catabolic functions in strictly controlled environments. Although cellular membranes are generally visualized as flat sheets or closely folded isolated objects, multiple observations also demonstrate that membranes may fold into "unusual", highly organized structures with 2D or 3D periodicity. The obvious correlation of highly convoluted membrane organizations with pathological cellular states, for example, as a consequence of viral infection, deserves close consideration. However, knowledge about formation and function of these highly organized 3D periodic membrane structures is scarce, primarily due to the lack of appropriate techniques for their analysis in vivo. Currently, the only direct way to characterize cellular membrane architecture is by transmission electron microscopy (TEM). However, deciphering the spatial architecture solely based on two-dimensionally projected TEM images is a challenging task and prone to artifacts. In this review, we will provide an update on the current progress in identifying and analyzing 3D membrane architectures in biological systems, with a special focus on membranes with cubic symmetry, and their potential role in physiological and pathophysiological conditions. Proteomics and lipidomics approaches in defined experimental cell systems may prove instrumental to understand formation and function of 3D membrane morphologies.

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Section: Muscular Dystrophymentioning

confidence: 99%

Chapter 6 Cubic Membranes

Almsherqi

Landh

Kohlwein

et al. 2009

International Review of Cell and Molecular Biology

131

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Formation of Unique Vacuoles in Tenotomized Rat Soleus Muscle Fibers.

Salem

Fujimaki

Ishikawa

2001

Archives of Histology and Cytology

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The formation of unique vacuoles in tenotomized rat soleus muscle fibers was examined by light and electron microscopy. After tenotomy at both proximal and distal tendons, virtually all muscle fibers underwent characteristic degenerative changes with a disorganization of myofibrils called the central core lesion, but eventually recovered. At 3 days after tenotomy, some muscle fibers showed small vacuoles in the sarcoplasm of the end segments, which were larger in diameter and paler in staining than those of the control fibers in light microscopy. At 5 days, more fibers formed larger vacuoles together with the extensive disorganization of myofibrils. Such vacuole formation was more conspicuous in the distal end than in the proximal end. At 1 week the myofibrillar disorganization was most extensive in the central areas, and vacuoles were considerably enlarged in some fibers to occupy most of the sarcoplasm near the fiber ends. Vacuoles decreased in number and size with time and could rarely be seen at 4 weeks postoperative. In thin-section electron microscopy, the early forms of vacuoles were often connected with the T-system tubules. The limiting membrane of such vacuoles possessed many caveolae, some of which appeared to be continuous with the T-system networks. The vacuole membrane was closely associated with the sarcoplasmic reticulum to form dyadic connections. In later stages, the vacuole membrane was lined in part with the basal lamina. From these findings, it can be concluded that the vacuoles are sarcolemmal in nature and derived from the T-system. The significances of the vacuole formation are discussed with special reference to the mechanism and fate of the vacuoles and their clinical implications.

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Tubular networks in soleus muscle fibers of the rat following tenotomy. I. Spatial organization

Cited by 2 publications

References 11 publications

Chapter 6 Cubic Membranes

Chapter 6 Cubic Membranes

Formation of Unique Vacuoles in Tenotomized Rat Soleus Muscle Fibers.

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