Tubular Poly(<i>ε</i>-caprolactone)/Chitosan Nanofibrous Scaffold Prepared by Electrospinning for Vascular Tissue Engineering Applications

Rez, Mohammed FayezAL; Binobaid, Abdullah Obaid; Alghosen, Abdulmajeed; Mirza, Eraj Humayun; Alam, Javed; Fouad, H.; Hashem, Mohamed; Alsalman, Hussain; Almalak, Hassan; Mahmood, Amer; Moussa, Ihab M.; Al-Jassir, FawziF.

doi:10.1166/jbt.2017.1593

Cited by 15 publications

(10 citation statements)

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“…A number of natural/synthetic polymeric fibrous scaffolds have been fabricated by electrospinning through natural and synthetic polymer mixture solution. [16][17][18] However, the uneven distribution of natural polymer within the synthetic polymer matrix might occur due to their poor compatibility, which will result in the limitation of natural polymer component content. [19] Furthermore, the most natural polymer would be embedded in synthetic polymer matrix, leading to poor cell recognition sites and weak capacity to interact with cells.…”

Section: Doi: 101002/mame201700277mentioning

confidence: 99%

“…The most common approaches for improving in the biochemical properties of synthetic polymer scaffold are surface coating or blending with natural polymers. A number of natural/synthetic polymeric fibrous scaffolds have been fabricated by electrospinning through natural and synthetic polymer mixture solution . However, the uneven distribution of natural polymer within the synthetic polymer matrix might occur due to their poor compatibility, which will result in the limitation of natural polymer component content .…”

Section: Introductionmentioning

confidence: 99%

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Surface Modification of Electrospun TPU Nanofiber Scaffold with CNF Particles by Ultrasound‐Assisted Technique for Tissue Engineering

Cui

et al. 2017

Macro Materials & Eng

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A straightforward, fast, and versatile technique is developed to fabricate nanofibrous scaffold with excellent hydrophilicity, mechanical properties, and biocompatibility for tissue engineering. The thermoplastic polyurethane (TPU) nanofiber is fabricated by utilizing electrospinning, and then its surface is modified through simply immersing it into cellulose nanofibrils (CNF) dispersion and subjecting to ultrasonication. The results show that the CNF particles are successfully absorbed on the surface of TPU nanofiber. By introducing CNF particles on the surface of TPU nanofiber, the hydrophilicity, mechanical properties of fabricated CNF‐absorbed TPU scaffold are significantly increased. Additionally, the adhesion and proliferation of human umbilical vein endothelial cells cultured on CNF‐absorbed TPU scaffold are prominently enhanced in comparison with those of cultured on TPU scaffold. These findings suggest that the ultrasound‐assisted technique opens up a new way to simply and effectively modify the surface of various scaffolds and the modified scaffold could be shown a great potential in tissue engineering.

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Section: Doi: 101002/mame201700277mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Surface Modification of Electrospun TPU Nanofiber Scaffold with CNF Particles by Ultrasound‐Assisted Technique for Tissue Engineering

Cui

et al. 2017

Macro Materials & Eng

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“…Biodegradation of a tissue scaffold is highly important if the aim of the scaffold is to provide rapid and natural cell proliferation . It is known that PCL has good biodegradation kinetics depending on time and temperature as affecting parameters which makes it as a suitable material for tissue engineering application.…”

Section: Resultsmentioning

confidence: 99%

“…Bioactive compounds in microalgal extract show antioxidant, proliferative, anticancer, antihypertensive, and antimicrobial activity . Microalgal extracts are also a promising candidate on regenerative tissue engineering for cardiovascular system . Recent developments in materials technology acknowledge the cell growth enhancers as support for tissue engineering.…”

Section: Introductionmentioning

confidence: 99%

“…However, the approach in this study to use microalgal carotenoids dense extracts as cell support materials are a new perspective of the development of the field. HUVEC cell line was chosen for cell culture experiments due to increasing demand on the development of cardiovascular tissue engineering materials . HUVEC cells could be utilized as a good starting cell line for the development of vascularized cardiac tissue engineering .…”

Section: Introductionmentioning

confidence: 99%

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Preparation of electrospun polycaprolactone nanofiber mats loaded with microalgal extracts

Cetmi

Renkler

Köse

et al. 2019

Engineering in Life Sciences

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Sustainable, ecological, and biocompatible materials are emerging for the development of novel components for tissue engineering. Microalgae being one of the unique organisms on Earth to provide various novel compounds with certain bioactivities are also a good source for the development of novel tissue scaffold materials. In this study, electrospinning technique was utilized to fabricate nanofibers from polycaprolactone loaded with microalgal extracts obtained from Haematococcus pluvialis (vegetative and carotenoid producing form) and Chlorella vulgaris. The FTIR results showed that, blending microalgae with polycaprolactone give unique bands rooted from microalgae and polycaprolactone structure. The samples were not diversified from each other, however stable bands were observed. SEM analysis revealed a uniform fiber fabrication with an average diameter of 810 ± 55 nm independent from microalgal extracts. MTT assay was done on HUVEC cell lines and results showed that nanofiber mats helped cell proliferation with extended time. Biodegradation resulted with mineral accumulation on the surface of same samples however the fiber degradation was uniform. With slow but stable biodegradation characteristics, microalgal extract loaded nanofiber mats holds great potential to be novel tissue scaffold material.

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3D Printing Artificial Blood Vessel Constructs Using PCL/Chitosan/Hydrogel Biocomposites

et al. 2019

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The present paper aims to overcome the problems related to previous use of autologous grafts using available synthetic grafts. To examine the optimum of the ideal vessel-like constructs parameters are produced at 230°C. At this production temperature, the elastic modulus values of the constructs ranges from 56 MPa to 174 MPa. The maximum cell proliferation is obtained from PCL/7wt.%CS/5wt.%H that is tested by mitochondrial dehydrogenase activity. The structures are visualized with all constructs after cell fixation by making use of the HUVEC cell line.[a] Dr.

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Tubular Poly(ε-caprolactone)/Chitosan Nanofibrous Scaffold Prepared by Electrospinning for Vascular Tissue Engineering Applications

Cited by 15 publications

References 0 publications

Surface Modification of Electrospun TPU Nanofiber Scaffold with CNF Particles by Ultrasound‐Assisted Technique for Tissue Engineering

Surface Modification of Electrospun TPU Nanofiber Scaffold with CNF Particles by Ultrasound‐Assisted Technique for Tissue Engineering

Preparation of electrospun polycaprolactone nanofiber mats loaded with microalgal extracts

3D Printing Artificial Blood Vessel Constructs Using PCL/Chitosan/Hydrogel Biocomposites

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