Tubulocystic carcinoma of the kidney with poorly differentiated foci: a series of 3 cases with fluorescence in situ hybridization analysis

Gains of chromosomes 7 and 17 in tubulocystic carcinoma of kidney: two cases with fluorescence in situ hybridisation analysis

“…In a report of 13 cases described as low-grade mucinous tubulocystic carcinoma of possible collecting duct origin, eight showed typical features of tubulocystic carcinoma 8. Sporadic cases showing coexistence of TCC with other subtypes of renal tumour were also reported,3 5–7 9 10 including cases of TCC together with poorly differentiated foci or sarcomatoid features 11 12. Although various association with other renal cell tumour subtypes has been implicated, it appears that there is a slight predominance for synchronous TCC and PRCC.…”

“…Although various association with other renal cell tumour subtypes has been implicated, it appears that there is a slight predominance for synchronous TCC and PRCC. Three studies1 3 11 examined molecular/cytogenetic changes of TCC by FISH or comparative genomic microarray analysis (CGMA) (table 1). Significantly, Zhou et al showed gains of chromosomes 7 and 17 in TCC and PRCC, suggesting these two tumour types were closely related 1.…”

Tubulocystic renal cell carcinoma: Report of a rare case

“…5 Solid areas, small foci of clear cell change or papillary configuration are rare, and may herald aggressive behaviour and worsen clinical outcome. 2,6,7 However, more recent data have suggested that TC-RCCs with focal dedifferentiation (TC-D-RCC) may actually represent hereditary leiomyomatosis RCC syndrome -associated RCC (HLRCC), as some TC-D-RCC cases show loss of fumarate hydratase immunoexpression and S-(2-Succino)-Cysteine (2SC) immunopositivity, similar to HLRCC (Table 1). 8 The histogenesis of TC-RCC remains unclear.…”

“…1 However, local recurrences, as well as metastases to lymph nodes, liver, bone and brain have been described. [2][3][4][5][6][7]13 One cannot at present be certain of the outcome, especially in unusual cases where there is focal clear cell, papillary or sarcomatoid change.…”

Les tumeurs rénales : recommandations de la conférence de consensus de l’International Society of Urologic Pathology (ISUP) 2012

“…En général il s'agit des tumeurs de bas stade (pT1, pT2). Un cas avec récidive locale et 4 cas métastatiques [ganglions pelviens, foie, os] ont été rapportés[4][5][6].…”