Tubulocystic renal carcinoma: a clinical perspective

Hora, Milan; Ürge, Tomáš; Eret, Viktor; Stránský, Petr; Klečka, Jiří; Kreuzberg, Boris; Ferda, Jiří; Hyrsl, L; Breza, J; Holečková, Petra; Mego, Michal; Michal, Michal; Petersson, Fredrik; Hes, Ondřej

doi:10.1007/s00345-010-0614-7

Cited by 26 publications

(12 citation statements)

References 18 publications

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“…Tubulocystic carcinomas of the kidney occur most commonly in the fifth and sixth decades of life and there is a strong male predominance [3,6,[10][11][12]. Most TCKs are discovered incidentally and are typically small in size (almost 40% are smaller than 2 cm) [3,13,14].…”

Section: Clinical Characteristicsmentioning

confidence: 99%

“…Radiologically, TCK may demonstrate Bosniak type II, type III or even type IV. Hence, this disease may pose a serious challenge in differential diagnosis and clinical management [6,11,15]. The radiological features of TCK overlap with other benign or malignant lesions including cystic nephroma (CN), mixed epithelial and stromal tumor (MEST), renal oncocytoma (RO) with tubulocystic pattern, multilocular cystic RCC and renal carcinoma associated with Xp11.2 translocations/TFE3 gene fusions (Xp11.2 RCC).…”

Section: Clinical Characteristicsmentioning

confidence: 99%

“…The radiological features of TCK overlap with other benign or malignant lesions including cystic nephroma (CN), mixed epithelial and stromal tumor (MEST), renal oncocytoma (RO) with tubulocystic pattern, multilocular cystic RCC and renal carcinoma associated with Xp11.2 translocations/TFE3 gene fusions (Xp11.2 RCC). 18-fluorodeoxyglucose (FDG) positron emission tomography/CT is useful in the detection of metastatic lesions [11]. Tubulocystic carcinomas of the kidney may occur in patients with end-stage kidney disease [16].…”

Section: Clinical Characteristicsmentioning

confidence: 99%

“…The tumors are well circumscribed but unencapsulated, with a white or gray color [3,11,15]. The cut surface demonstrates various-sized cysts giving the tumor a spongy, wrapped bubble-like, or Swiss cheese-like appearance ( Fig.…”

Section: Macroscopic Findingsmentioning

confidence: 99%

“…There is limited information on the potential beneficial effects of molecular target therapy to date. Sunitinib, a tyrosine kinase inhibitor, may exhibit a partial response or temporary effect for this tumor [11,32]. Tubulocystic carcinoma of the kidney with sarcomatoid change has responded poorly to sorafenib [21].…”

Section: Therapymentioning

confidence: 99%

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Review of tubulocystic carcinoma of the kidney with focus on clinical and pathobiological aspects

Matsumoto¹,

Ohe²,

Mikami³

et al. 2013

pjp

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Tubulocystic carcinoma of the kidney (TCK) is a recently established entity in renal neoplastic pathology. This review aims to give an overview of the clinical and pathobiological aspects of TCK. Grossly, the TCKs are well-demarcated multicystic lesions giving a "wrapped bubble" or "spongy" appearance. Microscopically, the tumors are composed of multiple, variably sized cysts separated by thin fibrous septa lacking ovarian stroma or desmoplastic reaction. The cysts are lined by tumor cells with eosinophilic cytoplasm and nuclear atypia of variable, but not infrequently of high grade corresponding to Fuhrman grade 3. A frequent association with papillary tumors has been reported. Recent molecular genetic studies of TCK have revealed distinct features separating this subset of renal cell carcinomas (RCCs) from other types of renal tumors including collecting duct carcinoma of Bellini and renal medullary carcinoma as well as pointing towards a close kinship with papillary RCC. Tubulocystic carcinoma of the kidney generally pursues an indolent clinical course. However, several cases with aggressive clinical behavior have been reported. We strongly feel that there is enough clinicopathological evidence to corroborate TCK as a separate entity and that it should be incorporated into the next WHO classification of renal tumors as a separate neoplastic category.

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Section: Clinical Characteristicsmentioning

confidence: 99%

Section: Clinical Characteristicsmentioning

confidence: 99%

Section: Clinical Characteristicsmentioning

confidence: 99%

Section: Macroscopic Findingsmentioning

confidence: 99%

Section: Therapymentioning

confidence: 99%

See 3 more Smart Citations

Review of tubulocystic carcinoma of the kidney with focus on clinical and pathobiological aspects

Matsumoto¹,

Ohe²,

Mikami³

et al. 2013

pjp

Self Cite

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Imaging features of papillary renal cell carcinoma with cystic change-dominant appearance in the era of the 2016 WHO classification

et al. 2017

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Tubulocystic renal cell carcinoma: a review of literature focused on radiological findings for differential diagnosis

et al. 2018

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Tubulocystic renal cell carcinoma (TC-RCC) has been classified as an independent subtype according to the 2016 World Health Organization (WHO) classification. It is a rare subtype that predominantly affects men. Although few in number, radiological imaging reports have suggested that TC-RCC is characterized by multilocular cystic lesions, which are categorized as the Bosniak classification II-IV, with signature pathological characteristics comprising numerous small cysts or a tubular structure. The Bosniak classification system facilitates patient management; however, the differentiation of cystic tumors exhibiting similar imaging findings remains impossible; in fact, the differentiation of multilocular cystic RCC, adult cystic nephroma, and mixed epithelial and stromal tumor remains challenging. This review aims to discuss TC-RCC with a focus on implications of radiological findings in the differential diagnosis of TC-RCC.

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Tubulocystic renal carcinoma: a clinical perspective

Cited by 26 publications

References 18 publications

Review of tubulocystic carcinoma of the kidney with focus on clinical and pathobiological aspects

Review of tubulocystic carcinoma of the kidney with focus on clinical and pathobiological aspects

Imaging features of papillary renal cell carcinoma with cystic change-dominant appearance in the era of the 2016 WHO classification

Tubulocystic renal cell carcinoma: a review of literature focused on radiological findings for differential diagnosis

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