Tubulointerstitial Nephritis and Mediterranean Spotted Fever

Acute Renal Failure as a Complication of Mediterranean Spotted Fever

“…As with the 2 previously reported cases [6,7], we could only demonstrate tubulointersti tial involvement: no specific vascular lesions were observed. The pathological changes de scribed in rickettsial diseases in other tissues are vascular, being especially common in skin, muscles, heart, lung, and brain [10].…”

“…microhematuria, and mild renal failure, are relatively common consequences of R. conorii infection. These abnormalities are re-ported in up to 50% o f the patients [2][3][4][5], Ma jo r renal involvement sueh as acute renal fail ure has only rarely been described [6][7][8]. When present, it has been usually associated with dehydratation, high fever, and vomiting in critically ill patients.…”

Mediterranean Spotted Fever with Acute Renal Failure Simulating a Relapse in C-ANCA Vasculitis

“…Usually acute renal failure is described in patients in critical conditions with severe dehydration caused by high fever and vomiting [1, 2]. In the few cases of acute renal failure occurring in patients with Mediterranean spotted fever in whom a renal biopsy was carried out, acute tubular necrosis [1] or tubular interstitial nephritis [2, 3] has been demonstrated. A vasculitic syndrome has never been documented in the kidney [2].…”