Tucson children's respiratory study: 1980 to present

Taussig, Lynn M.; Wright, Anne L.; Holberg, Catharine J.; Halonen, Marilyn; Morgan, Wayne J.; Martínez, Fernando D.

doi:10.1067/mai.2003.162

Cited by 566 publications

(509 citation statements)

References 57 publications

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“…Medication use was preferred rather than reported symptoms since most infants with wheezing do not develop asthma 18 , and most pediatricians identify the response to asthma medications as necessary in establishing a diagnosis of asthma. 19 All medications were recorded at each study visit from birth for all WITS patients.…”

Section: Diagnosis Of Asthmamentioning

confidence: 99%

Increased incidence of asthma in HIV-infected children treated with highly active antiretroviral therapy in the National Institutes of Health Women and Infants Transmission Study

Foster

McIntosh

Thompson

et al. 2008

Journal of Allergy and Clinical Immunology

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Section: Diagnosis Of Asthmamentioning

confidence: 99%

Increased incidence of asthma in HIV-infected children treated with highly active antiretroviral therapy in the National Institutes of Health Women and Infants Transmission Study

Foster

McIntosh

Thompson

et al. 2008

Journal of Allergy and Clinical Immunology

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“…This was associated with maternal asthma, male sex and a history of rhinitis [1]. This group tended to be atopic and show normal lung function at birth and through the teenage years [42].…”

Section: Multiple-trigger Wheezementioning

confidence: 99%

Definition, assessment and treatment of wheezing disorders in preschool children: an evidence-based approach

Brand¹,

Baraldi²,

Bisgaard³

et al. 2008

Eur Respir J

750

759

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There is poor agreement on definitions of different phenotypes of preschool wheezing disorders. The present Task Force proposes to use the terms episodic (viral) wheeze to describe children who wheeze intermittently and are well between episodes, and multiple-trigger wheeze for children who wheeze both during and outside discrete episodes. Investigations are only needed when in doubt about the diagnosis.Based on the limited evidence available, inhaled short-acting b 2 -agonists by metered-dose inhaler/spacer combination are recommended for symptomatic relief. Educating parents regarding causative factors and treatment is useful. Exposure to tobacco smoke should be avoided; allergen avoidance may be considered when sensitisation has been established. Maintenance treatment with inhaled corticosteroids is recommended for multiple-trigger wheeze; benefits are often small. Montelukast is recommended for the treatment of episodic (viral) wheeze and can be started when symptoms of a viral cold develop.Given the large overlap in phenotypes, and the fact that patients can move from one phenotype to another, inhaled corticosteroids and montelukast may be considered on a trial basis in almost any preschool child with recurrent wheeze, but should be discontinued if there is no clear clinical benefit.Large well-designed randomised controlled trials with clear descriptions of patients are needed to improve the present recommendations on the treatment of these common syndromes.

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“…However, in preschool aged children, wheezing is a common manifestation of viral respiratory tract infections, 35 and properly diagnosing asthma in this age group so that appropriate treatment can be initiated has posed a challenge for many clinicians. On the one hand, early recognition and treatment may be important in altering the natural history of the disease in terms of both symptom and exacerbation control as well as loss of lung function.…”

Section: Childhood Asthma Research and Education (Care) Network The Pmentioning

confidence: 99%

“…reduced growth velocity from ICS). [35][36][37] To address these critical questions in childhood asthma, the first trial conducted by the CARE network was Prevention of Early Asthma in Kids (PEAK) study. 38 The main research question posed by PEAK was as follows: can early recognition and treatment of children at increased risk of developing asthma prevent its clinical expression or any alterations in lung function measures that occur as a result of it?…”

Section: Childhood Asthma Research and Education (Care) Network The Pmentioning

confidence: 99%

Guideline-defining asthma clinical trials of the National Heart, Lung, and Blood Institute's Asthma Clinical Research Network and Childhood Asthma Research and Education Network

Denlinger¹,

Sorkness²,

Chinchilli

et al. 2007

Journal of Allergy and Clinical Immunology

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Due to an increasing prevalence, morbidity and mortality associated with asthma, the National Heart, Lung and Blood Institute created the Asthma Clinical Research Network (ACRN) and the Childhood Asthma Research and Education (CARE) Network to improve public health. The objectives of these clinical research networks are to conduct multiple, well designed clinical trials for rapid evaluation of new and existing therapeutic approaches to asthma and to disseminate laboratory and clinical findings to the health care community. These trials comprise a large proportion of the data driving the treatment guidelines established and reviewed by the National Asthma Education and Prevention Program. This article will review the basic design and major findings of selected ACRN and CARE Network trials involving both adults and children with asthma. Collectively, these studies have helped refine the therapeutic role of existing controller medications, establish standard models for side effect evaluation and risk-benefit models, validate symptom based assessments for asthma control, and identify baseline characteristics that may predict individual patient responses. Remaining challenges include shaping the role of novel therapeutics in future guidelines, incorporating pharmacogenomic data in treatment decisions, and establishing better implementation strategies for translation to community settings, all with the goal of reducing the asthma burden on society.

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Tucson children's respiratory study: 1980 to present

Cited by 566 publications

References 57 publications

Increased incidence of asthma in HIV-infected children treated with highly active antiretroviral therapy in the National Institutes of Health Women and Infants Transmission Study

Increased incidence of asthma in HIV-infected children treated with highly active antiretroviral therapy in the National Institutes of Health Women and Infants Transmission Study

Definition, assessment and treatment of wheezing disorders in preschool children: an evidence-based approach

Guideline-defining asthma clinical trials of the National Heart, Lung, and Blood Institute's Asthma Clinical Research Network and Childhood Asthma Research and Education Network

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