Tuft cells: an emerging therapeutic target for pancreatitis and pancreatic cancer?

Yang, Yuning; Ding, Ling; Cao, Zhiyun; Qu, Dongfeng; Weygant, Nathaniel

doi:10.1080/14728222.2020.1841168

Cited by 3 publications

(1 citation statement)

References 15 publications

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“…The identification of unique gene markers in tuft cells has enabled the exploration of their association with cancer [14]. For instance, DCLK1 has been found to be upregulated in renal clear cell cancer, pancreatic cancer, and colorectal cancer [68][69][70][71]. Moreover, KRAS mutant Dclk1 + cells can functionally contribute to the pathogenesis of pancreatic cancer and, therefore, are a potential target in cancer treatment [72].…”

Section: Tuft Cells In Intestinal Homeostasis and Cancermentioning

confidence: 99%

Tuft Cells: Detectors, Amplifiers, Effectors and Targets in Parasite Infection

Campillo Poveda,

Britton,

Devaney

et al. 2023

Cells

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Tuft cells have recently emerged as the focus of intense interest following the discovery of their chemosensory role in the intestinal tract, and their ability to activate Type 2 immune responses to helminth parasites. Moreover, they populate a wide range of mucosal tissues and are intimately connected to immune and neuronal cells, either directly or through the release of pharmacologically active mediators. They are now recognised to fulfil both homeostatic roles, in metabolism and tissue integrity, as well as acting as the first sensors of parasite infection, immunity to which is lost in their absence. In this review we focus primarily on the importance of tuft cells in the intestinal niche, but also link to their more generalised physiological role and discuss their potential as targets for the treatment of gastrointestinal disorders.

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