Tufted angioma (Angioblastoma) of eyelid in adults-report of two cases

Abstract

Tufted angioma, first recognized in Japanese literature as “Angioblastoma of Nagakawa”, is a rare benign vascular tumour with a variable clinical presentation. It commonly manifests as a macule, papule or nodule in infancy or childhood in the region of the upper trunk and neck. Here in we report two cases of this rare progressive angioma as lesions of the eyelid in adults. Tufted angioma has a classical “cannon ball” like appearance of vascular tufts on histopathology. Immunohistochemical staining with actin highlights the spindly stromal cells surrounding the capillaries. Complete physical examination and haematological work up is recommended in patients with tufted angioma to exclude rare association of port wine stain and Kasabach-Merritt syndrome with this rare entity. To the best of our knowledge, our cases illustrate the first case report of tufted angioma presenting as an eyelid lesion.Virtual SlidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1230909536950947.

Destructive (Erosive) Tufted Angioma/Kaposiform Hemangioendothelioma of the Eyelid

“…Although very few cases involving the eyelids were reported, none was associated with tissue destruction, ulceration, or erosion [4], [5]. The pathogenesis of the destruction of the eyelid margin in the present case is not known, though it may be due to a compromised blood supply by the newly formed blood vessels and the nature of vasculature of the eyelid margin rather than tumor related as it has been observed only in eyelid margin lesions.…”

Multifocal annular tufted angioma: An uncommon clinical entity

“…[ 3 4 ] TA usually presents as a macule, papule or plaque over the upper trunk, neck and proximal part of the limbs; involvement of other locations like face, oral mucosa and lip is also known. [ 5 ] TA is a sporadic disease with more than half of the cases occurring during the first 5 years of life. However, familial cases have also been reported.…”

Acquired capillary hemangioma of the eyelid in a 49-year-old woman from Turkey

“…The main differential diagnoses for ACH are, pyogenic granuloma, angiosarcoma, and acquired tufted angioma of the eyelids. [ 10 11 ] Acquired tufted angioma of the eyelid is also a rare entity. A recent report about tufted angioma of the eyelid was published in two patients.…”

“…[ 12 ] Histopathologically, angiomatous lobules of tufted angioma are composed of relatively bloodless and poorly canalized capillaries which are lined by plump endothelial cells. [ 11 ] Tufted angioma in childhood needs differentiation from juvenil hemangioma. Angiomatous lobules of juvenile hemangiomas are more massive, and lesions tend to have involvement of deeper periocular structures at later stages.…”