2022
DOI: 10.1155/2022/1590717
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Tuftelin 1 Facilitates Hepatocellular Carcinoma Progression through Regulation of Lipogenesis and Focal Adhesion Maturation

Abstract: Hepatocellular carcinoma (HCC) is the most common type of primary liver malignancy with poor prognosis worldwide. Emerging evidences demonstrated critical roles of lipid de novo synthesis in HCC progression, yet its regulatory mechanisms are not fully understood. Herein, we found that tuftelin 1 (TUFT1), an acidic phosphorylated glycoprotein with secretory capacity, was significantly upregulated in HCC and had an excellent correlation with patient survival and malignancy features. Through database mining and e… Show more

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Cited by 3 publications
(2 citation statements)
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“…Exosomal lncRNA HNF1A antisense RNA 1 (HNF1A-AS1) is another example of this group of nucleic acids that, by decreasing miR-34b expression, promotes tuftelin 1 (TUFT1) expression, thus contributing to the acquisition of cervical cancer cell resistance to cisplatin by enhancing cancer cell proliferation and inhibiting apoptosis [ 39 ]. One universal concept that has emerged from previous studies is that TUFT1 promotes cancer development and progression through different signaling pathways [ 66 , 67 , 68 , 69 , 70 ]. High expression of this protein is associated with poor prognosis in several types of cancer, including thyroid cancer [ 70 ], liver cancer [ 69 , 71 ], pancreatic cancer [ 66 ], gastric cancer [ 67 ], lung cancer [ 67 ], and breast cancer [ 67 , 72 ].…”
Section: Exosomes As Chemoresistance Mediatorsmentioning
confidence: 99%
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“…Exosomal lncRNA HNF1A antisense RNA 1 (HNF1A-AS1) is another example of this group of nucleic acids that, by decreasing miR-34b expression, promotes tuftelin 1 (TUFT1) expression, thus contributing to the acquisition of cervical cancer cell resistance to cisplatin by enhancing cancer cell proliferation and inhibiting apoptosis [ 39 ]. One universal concept that has emerged from previous studies is that TUFT1 promotes cancer development and progression through different signaling pathways [ 66 , 67 , 68 , 69 , 70 ]. High expression of this protein is associated with poor prognosis in several types of cancer, including thyroid cancer [ 70 ], liver cancer [ 69 , 71 ], pancreatic cancer [ 66 ], gastric cancer [ 67 ], lung cancer [ 67 ], and breast cancer [ 67 , 72 ].…”
Section: Exosomes As Chemoresistance Mediatorsmentioning
confidence: 99%
“…One universal concept that has emerged from previous studies is that TUFT1 promotes cancer development and progression through different signaling pathways [ 66 , 67 , 68 , 69 , 70 ]. High expression of this protein is associated with poor prognosis in several types of cancer, including thyroid cancer [ 70 ], liver cancer [ 69 , 71 ], pancreatic cancer [ 66 ], gastric cancer [ 67 ], lung cancer [ 67 ], and breast cancer [ 67 , 72 ]. From this perspective, taking into account the enormous commitment of TUFT1 to carcinogenesis and its related processes, the lncRNA HNF1A-AS1/miR-34b/TUFT1 axis is a tempting exemplification of continuing research into targeted therapy aimed at inhibiting the release and transport of exosomes with high lncRNA HNF1A-AS1 expression [ 39 ].…”
Section: Exosomes As Chemoresistance Mediatorsmentioning
confidence: 99%