Tuftsin-Bearing Liposomes Co-Encapsulated with Doxorubicin and Curcumin Efficiently Inhibit EAC Tumor Growth in Mice

Murugesan, Kalaimathi; Srinivasan, P.; Mahadeva, Raghunandan; Gupta, Chhitar M; Haq, W.

doi:10.2147/ijn.s276336

Cited by 15 publications

(11 citation statements)

References 40 publications

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“…TF are endogenous small-molecule peptides that are important components of the natural immune system [ 1 ]. In recent years, TF has been found to possess good anti-tumor activity, making it a novel therapeutic agent that treats multiple conditions [ 24 ]. We conducted a comprehensive evaluation of its biological activity in vitro , a partial study of its mechanism of action, and a preliminary study of its anti-tumor activity in a mouse tumor transplant model [ 16 ].…”

Section: Discussionmentioning

confidence: 99%

Tuftsin-tailored fusion protein inhibits the growth of circulating gastric tumor cells associated with macrophage phagocytosis

Yuan¹,

Zhai²,

Zhu³

et al. 2023

Biochemistry and Biophysics Reports

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Section: Discussionmentioning

confidence: 99%

Tuftsin-tailored fusion protein inhibits the growth of circulating gastric tumor cells associated with macrophage phagocytosis

Yuan¹,

Zhai²,

Zhu³

et al. 2023

Biochemistry and Biophysics Reports

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“…The use of nanocarrier-based combination therapy requires considerable effort to study and confirm the benefits of synergistic effects [9] and fluorescence microscopy is often involved in the work [85]. Nanomedicine pays special attention to molecular imaging [4,5,8,12,23,71,[83][84][85][86][87][88][89][90][91], and fluorescent probes [89] are widely used for diagnosis and treatment [55]. The intracellular distribution of nanoparticles and chemopreparations directly in different parts of the cell is visualized using images of confocal fluorescence laser scanning microscopy [12,23].…”

Section: Curcumin and Doxorubicinmentioning

confidence: 99%

“…

The current advanced strategy in chemotherapy is aimed at combination therapy, which uses targeted delivery systems with a large number of drugs [1][2][3][4]. Therapy with one drug is limited due to the heterogeneity of cancer cells [5], therefore, today, combined chemotherapy has become a standard treatment scheme for cancer patients [2, 5] and is expedient and promising [1,3,4].Combined therapy is becoming an important strategy for a better long-term prognosis with reduced side effects [6,7]. The combination of chemotherapy drugs allows oncologists to use drugs in lower doses, reducing cytotoxicity [5] and increasing the effectiveness of treatment [1].

…”

mentioning

confidence: 99%

Combined Nanochemotherapy Using Doxorubicin and Curcumin as an Example

Kaniuk¹

2023

Biotechnol. acta

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The aim of the work was to review literature data on combined nanochemotherapy using the example of two drugs ̶doxorubicin and curcumin. Special attention was paid to the use of substances with synergistic properties in one nanoparticle, capable to penetrate into living cell. The method of combined chemotherapy of nanopreparations improves processing efficiency. The technique of using nanocontainers with synergistic drugs in combination with ligands reduces the side effects of chemotherapy drugs. Results. Literature data indicate that the use of nanopreparations contributes the rapid creation and use of synergistic combinations that were purposefully delivered to target cells, reducing dosage due to precise targeting. A promising direction of nanomedicine is the creation of multifunctional nanomaterials based on several active drugs having synergistic properties, with the simultaneous use of their enhancers and the strategy of active targeting. These structures enabled targeted and controlled penetration of medicinal compounds into the localization of pathological processes, reducing drugs toxicity for normal cells. Conclusions. Combined chemotherapy using polymers and nanoparticles with ligands, in which synergistic drugs are included, ensures to reduce side effects and doses of chemotherapy drugs, and helps to overcome multiple drug resistance as well.

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“… 231 Recent experiments have exploited liposomes for delivery of DOX or its co‐delivery with other agents such as hispolon, curcumin, and linalool in combination cancer therapy. 232 , 233 , 234 , 235 Therefore, liposomal nanocarriers can provide delivery of DOX at the tumor site and this section focuses on CS‐modified liposomes in DOX delivery.…”

Section: Nanostructures Of Chitosan‐doxorubicinmentioning

confidence: 99%

“…The clinical application of liposomes has some impediments such as their rapid clearance, immune system activation, and accumulation in other organs 231 . Recent experiments have exploited liposomes for delivery of DOX or its co‐delivery with other agents such as hispolon, curcumin, and linalool in combination cancer therapy 232–235 . Therefore, liposomal nanocarriers can provide delivery of DOX at the tumor site and this section focuses on CS‐modified liposomes in DOX delivery.…”

Section: Nanostructures Of Chitosan‐doxorubicinmentioning

confidence: 99%

Chitosan‐based nanoscale systems for doxorubicin delivery: Exploring biomedical application in cancer therapy

Ashrafizadeh

Hushmandi

Mirzaei

et al. 2022

Bioengineering & Transla Med

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Green chemistry has been a growing multidisciplinary field in recent years showing great promise in biomedical applications, especially for cancer therapy. Chitosan (CS) is an abundant biopolymer derived from chitin and is present in insects and fungi. This polysaccharide has favorable characteristics, including biocompatibility, biodegradability, and ease of modification by enzymes and chemicals. CS‐based nanoparticles (CS‐NPs) have shown potential in the treatment of cancer and other diseases, affording targeted delivery and overcoming drug resistance. The current review emphasizes on the application of CS‐NPs for the delivery of a chemotherapeutic agent, doxorubicin (DOX), in cancer therapy as they promote internalization of DOX in cancer cells and prevent the activity of P‐glycoprotein (P‐gp) to reverse drug resistance. These nanoarchitectures can provide co‐delivery of DOX with antitumor agents such as curcumin and cisplatin to induce synergistic cancer therapy. Furthermore, co‐loading of DOX with siRNA, shRNA, and miRNA can suppress tumor progression and provide chemosensitivity. Various nanostructures, including lipid‐, carbon‐, polymeric‐ and metal‐based nanoparticles, are modifiable with CS for DOX delivery, while functionalization of CS‐NPs with ligands such as hyaluronic acid promotes selectivity toward tumor cells and prevents DOX resistance. The CS‐NPs demonstrate high encapsulation efficiency and due to protonation of amine groups of CS, pH‐sensitive release of DOX can occur. Furthermore, redox‐ and light‐responsive CS‐NPs have been prepared for DOX delivery in cancer treatment. Leveraging these characteristics and in view of the biocompatibility of CS‐NPs, we expect to soon see significant progress towards clinical translation.

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Tuftsin-Bearing Liposomes Co-Encapsulated with Doxorubicin and Curcumin Efficiently Inhibit EAC Tumor Growth in Mice

Cited by 15 publications

References 40 publications

Tuftsin-tailored fusion protein inhibits the growth of circulating gastric tumor cells associated with macrophage phagocytosis

Tuftsin-tailored fusion protein inhibits the growth of circulating gastric tumor cells associated with macrophage phagocytosis

Combined Nanochemotherapy Using Doxorubicin and Curcumin as an Example

Chitosan‐based nanoscale systems for doxorubicin delivery: Exploring biomedical application in cancer therapy

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