Tug of war: A bimanual technique for anterior circumferential proliferative vitreoretinopathy in recurrent retinal detachment

Shroff, Daraius; Saha, Indranil; Bhatia, Gagan; Dutta, Ranjan; Gupta, Charu; Shroff, Cyrus

doi:10.4103/ijo.ijo_2179_19

Cited by 3 publications

(1 citation statement)

References 16 publications

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“…Of no less importance was the advent of chandeliers for endoillumination, which makes it possible to perform bimanual techniques for membrane dissection and peeling in higher-grade PVR cases [ 138 ].…”

Section: Therapeutic Strategiesmentioning

confidence: 99%

Proliferative Vitreoretinopathy: A Reappraisal

Carpineto

Licata

Ciancaglini

2023

JCM

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Proliferative vitreoretinopathy (PVR) remains the main cause of failure after retinal detachment (RD) surgery. Despite the development of modern technologies and sophisticated techniques for the management of RD, the growth of fibrocellular membranes within the vitreous cavity and on both sides of the retinal surface, as well as intraretinal fibrosis, can compromise surgical outcomes. Since 1983, when the term PVR was coined by the Retina Society, a lot of knowledge has been obtained about the physiopathology and risk factors of PVR, but, despite the proposal of a lot of therapeutic challenges, surgical skills seem to be the only effective way to manage PVR complications.

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Section: Therapeutic Strategiesmentioning

confidence: 99%

Proliferative Vitreoretinopathy: A Reappraisal

Carpineto

Licata

Ciancaglini

2023

JCM

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Proliferative Vitreoretinopathy in Retinal Detachment: Perspectives on Building a Digital Twin Model Using Nintedanib

Visioli,

Romaniello,

Spinoglio

et al. 2024

IJMS

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Proliferative vitreoretinopathy (PVR) is a pathological process characterized by the formation of fibrotic membranes that contract and lead to recurrent retinal detachment. Pars plana vitrectomy (PPV) is the primary treatment, but recurrence rates remain high, as surgery does not address the underlying molecular mechanisms driving fibrosis. Despite several proposed pharmacological interventions, no approved therapies exist, partly due to challenges in conducting preclinical and in vivo studies for ethical and safety reasons. This review explores the potential of computational models and Digital Twins, which are increasingly gaining attention in medicine. These tools could enable the development of progressively complex PVR models, from basic simulations to patient-specific Digital Twins. Nintedanib, a tyrosine kinase inhibitor targeting PDGFR, VEGFR, and FGFR, is presented as a prototype for computational models to simulate its effects on fibrotic pathways in virtual patient cohorts. Although still in its early stages, the integration of computational models and Digital Twins offers promising avenues for improving PVR management through more personalized therapeutic strategies.

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Commentary: Management of proliferative vitreoretinopathy in recurrent retinal detachment

Babu

Kohli

2020

Indian J Ophthalmol

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Tug of war: A bimanual technique for anterior circumferential proliferative vitreoretinopathy in recurrent retinal detachment

Cited by 3 publications

References 16 publications

Proliferative Vitreoretinopathy: A Reappraisal

Proliferative Vitreoretinopathy: A Reappraisal

Proliferative Vitreoretinopathy in Retinal Detachment: Perspectives on Building a Digital Twin Model Using Nintedanib

Commentary: Management of proliferative vitreoretinopathy in recurrent retinal detachment

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