Tumefactive fibroinflammatory lesion of the maxilla: Successful resection and microvascular reconstruction after failed medical therapy

Higginson, James; Breik, Omar; Goodrum, Heather; Warfield, Adrian; Bates, Timothy; Rhodes, Benjamin; Martín, Timothy

doi:10.1007/s10006-020-00914-y

Cited by 3 publications

(1 citation statement)

References 15 publications

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“…In our literature review (Table ), there were two studies of TFILs focusing on the relationship with IgG4-RD. In the cases in those studies, sparse IgG4-positive cell infiltration (up to 30 cells per high-power field) were seen with normal serum IgG4 levels (6,14). IgG4-positive cell infiltration can thus be seen in cases with TFIL; however, the pathophysiological mechanism underlying the IgG4-positive cell infiltration in cases of TFIL remains unclear and should be addressed in future studies.…”

Section: Discussionmentioning

confidence: 88%

A Tumefactive Fibroinflammatory Lesion of the Head and Neck Mimicking Immunoglobulin G4-related Disease

et al. 2023

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A 67-year-old woman with a 5-year history of recurrent swollen eyelids and epistaxis, diagnosed as immunoglobulin G4-related diseases (IgG4-RD) based on hyper-IgG4-emia and IgG4-positive cell infiltration to the lesion, was referred to our department due to recurrent symptoms despite corticosteroid therapies. Computed tomography revealed an osteoclastic sinus mass with prominent neutrophil infiltration and necrosis that was incompatible with IgG4-RD histopathologically. Finally, she was diagnosed with a tumefactive fibroinflammatory lesion (TFIL) of the head and neck and treated with high-dose corticosteroids. Physicians should remember that TFIL can mimic IgG4-RD in the head and neck region with prominent neutrophil infiltration and necrosis.

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Section: Discussionmentioning

confidence: 88%