2021
DOI: 10.1016/j.msard.2020.102699
|View full text |Cite
|
Sign up to set email alerts
|

Tumefactive multiple sclerosis (TMS): A case series of this challenging variant of MS

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

1
9
0

Year Published

2021
2021
2024
2024

Publication Types

Select...
8

Relationship

0
8

Authors

Journals

citations
Cited by 15 publications
(10 citation statements)
references
References 13 publications
1
9
0
Order By: Relevance
“…One of its rare variants is tumefactive MS that has a prevalence of 1-3/1000 cases. It is quite challenging to diagnose due to its similar features with central nervous system neoplasms on the findings of MRI [ 15 ]. We, therefore, planned this study with the rationale to assess the clinical presentation of multiple sclerosis and neuromyelitis optica spectrum disorder in young patients in our community.…”
Section: Discussionmentioning
confidence: 99%
“…One of its rare variants is tumefactive MS that has a prevalence of 1-3/1000 cases. It is quite challenging to diagnose due to its similar features with central nervous system neoplasms on the findings of MRI [ 15 ]. We, therefore, planned this study with the rationale to assess the clinical presentation of multiple sclerosis and neuromyelitis optica spectrum disorder in young patients in our community.…”
Section: Discussionmentioning
confidence: 99%
“…A positive response to steroids (6) and the reduction of the size of the lesions in serial neuroimaging allows distinguishing the demyelinating nature of a tumefactive lesion from an abscess or neoplasm (3). However, challenges have been reported in diagnosing TMS by MRS and PET, without biopsy and careful follow-up by serial MRI with or without steroid treatment is usually sufficient to establish a diagnosis (8,20,21).…”
Section: Differential Diagnosismentioning
confidence: 99%
“…On the other hand, although CSF analysis has not shown statistical significance as a support for the diagnosis of TMS, it has been observed that the presence of oligoclonal bands and elevated immunoglobulin G has allowed determining demyelinating processes (9,20,21).…”
Section: Differential Diagnosismentioning
confidence: 99%
“…3 Although TD lesions (TDL) are most commonly associated with MS, they can be seen in other inflammatory conditions such as myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD), aquaporin-4-IgG seropositive neuromyelitis optic spectrum disorders (AQP4+ NMOSD), and acute demyelinating encephalomyelitis (ADEM). [4][5][6] In addition, there is clinical evidence that Balo concentric sclerosis (BCS) and Marburg disease commonly occur as tumefactive variants of MS. 7,8 These terms have been often used interchangeably, highlighting the diagnostic challenge, elusive pathophysiology, and overlapping features of these entities. The detection of TDL frequently leads to a diagnostic dilemma, particularly in patients without previously known underlying demyelinating disease.…”
Section: Introductionmentioning
confidence: 99%