Tumeurs épithéliales thymiques

Thomas, Philippe; Payan-Defais, Marie-José

doi:10.1016/j.pneumo.2009.12.004

Cited by 5 publications

(7 citation statements)

References 37 publications

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“…Thymic epithelial tumours represent 35 to 50% of anterior mediastinal masses [1]. Several systems have been used in their classification.…”

Section: Discussionmentioning

confidence: 99%

“…In 1999, the WHO published a histopathological classification of thymus tumours and classified thymoma into six types: A, AB, B1, B2, B3 and C. Thymic carcinomas are classified as thymoma type C in this first classification. It was updated in 2004 and then in 2015 and thymic carcinomas are considered to be a separate group from thymomas [1,3,7]. They represent less than 5% of all malignant thymus tumours and 15% of epithelial tumours.…”

Section: Discussionmentioning

confidence: 99%

“…Thymic epithelial tumours are rare pathologies but represent 20% of mediastinum tumours [1] and are the first cause of anterior mediastinal mass (35 to 50% of cases). According to World Health Organization (WHO) classification in 2004, thymic epithelial tumors are divided on three types: thymomas (80% of cases), thymic carcinomas and neuroendocrine tumours (5%) [2,3].…”

Section: Introductionmentioning

confidence: 99%

“…Itrepresent 5% of all malignant thymic tumours and 15% of thymic epithelial tumours. These are aggressive tumours [1,5]. The overall survival rate at 5 years is about 30 to 50%, and it is less than 20% between 5 and 10 years [6,7].…”

Section: Introductionmentioning

confidence: 99%

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Thymic Carcinomas Diagnosed at the Pathology Department at Jra Hospital

Raivoherivony

Rabarijaona

Ranaivoson

et al. 2022

IJRBP

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INTRODUCTION Thymic epithelial tumours are rare pathologies but represent 20% of mediastinum tumours [1] and are the first cause of anterior mediastinal mass (35 to 50% of cases). According to World Health Organization (WHO) classification in 2004, thymic epithelial tumors are divided on three types: thymomas (80% of cases), thymic carcinomas and neuroendocrine tumours (5%) [2, 3]. Thymic carcinomas have an incidence of 0.2 to 0.5 per million people [4]. Itrepresent 5% of all malignant thymic tumours and 15% of thymic epithelial tumours. These are aggressive tumours [1, 5]. The overall survival rate at 5 years is about 30 to 50%, and it is less than 20% between 5 and 10 years [6, 7]. The aim of our study is to describe the epidemiological and histopathologicalfeatures of thymic carcinomas, diagnosed at the Pathology Department, with a review of the literature. Materials and method This is a retrospective and descriptive study of thymic carcinomas diagnosed at the Pathology Departmentat JRAUniversity Hospital, during 10 years from January 2010 to December 2019.

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“…Thymic epithelial tumours represent 35 to 50% of anterior mediastinal masses [1]. Several systems have been used in their classification.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Thymic Carcinomas Diagnosed at the Pathology Department at Jra Hospital

Raivoherivony

Rabarijaona

Ranaivoson

et al. 2022

IJRBP

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“…A high expression of the Epidermal Growth Factor (EGFR) and HER has been reported especially in advanced tumors [29,89]. Moreover, the expression of Kit, assessed by immunohistochemistry, is characteristic of thymic carcinomas.…”

Section: Discussionmentioning

confidence: 99%

Review of the literature about Thymic Carcinomas

Mlika¹,

Mezni²

2017

Arch Pulmonol Respir Care

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Background: Thymic carcinomas (TC) are rare tumors with challenging diagnosis and management. We aimed to describe the clinical and microscopic characteristics of TC through a literature review.Results: 82 articles and abstracts were retained about 2913 TC. Our study contained 1760 men and 1153 women with a mean age of 55.32 years. The delay of diagnosis was specifi ed in 10 cases and varied between 8 months and 2 years. Symptoms consisted mainly in chest pain and dyspnea. The Computed Tomography-scan (CT-scan) fi ndings were specifi ed in 63 cases. Microscopic fi ndings were noticed in 1766 cases. They consisted mainly in squamous cell carcinoma in 1297 cases and undifferentiated carcinoma in 239 cases. The patients presented stage 1 tumors in 165 cases, stage II in 362 cases, stage III in 1011 cases and stage IV in 1166 cases. The treatment modalities were noticed in 2803 cases. There was no consensus of the regimen of chemotherapy or the place of the radiation therapy but all studies highlighted the key role of the complete surgical resection when possible. Conclusion:Our results highlight the lack of consensual management of TC. The chemotherapy regimen, the second-line chemotherapy and the indications of radiation therapy seem non-consensual and need further studies. Many interrogations remain concerning the management of these tumors according to their histologic grade. The real place of targeted therapy remains to assess and the rare opinions published are based on rare and non-representative cases.

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DNA methylation in thoracic neoplasms

Chen

Yin

et al. 2011

Cancer Letters

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Tumeurs épithéliales thymiques

Cited by 5 publications

References 37 publications

Thymic Carcinomas Diagnosed at the Pathology Department at Jra Hospital

Thymic Carcinomas Diagnosed at the Pathology Department at Jra Hospital

Review of the literature about Thymic Carcinomas

DNA methylation in thoracic neoplasms

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