Tumor angiogenesis: An independent prognostic parameter in cervical cancer

Bremer, Gérard L.; Tiebosch, A.T.M.G.; Putten, H.W.H.M. van der; Schouten, Hubert J. A.; Haan, J. de; Arends, Jan–Willem

doi:10.1016/s0002-9378(96)70384-8

Cited by 91 publications

(63 citation statements)

References 16 publications

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“…In three studies early recurrence was significantly related with high vessel density (Schlenger et al, 1995;Bremer et al, 1996;Dinh et al, 1996). In our study we found a similar, but not significant, association.…”

Section: Discussionsupporting

confidence: 78%

“…But it is likely that the highest count is not an optimal measurement between biopsy or hysterectomy specimen reflection of vessel density. -he same patient (Bremer et al, 1996). Therefore, we In our study population there was no significant relationship a biopsy specimen as representative for the stromal fracbetween the median vessel count and tumour histology, tumour he whole tumour.…”

Section: Digital Image Analysis and Immunohistochemical Evaluationmentioning

confidence: 71%

“…Based on a review of the literature we chose JC70, an anti-CD31 antibody, as marker for the microvessels as this endothelial marker is the most sensitive and specific of all and it does not react with lymphatic endothelium (Parums et al, 1990;Horak et al, 1992;Kuzu et al, 1992). However, of the seven previously published studies about invasive cervical cancer and angiogenesis, six used factor VIII (Kainz et al, 1995;Rutgers et al, 1995;Schlenger et al, 1995;Wiggens et al, 1995;Dinh et al, 1996;Abulafia et al, 1996), one Ulex europeaus lectin I (Bremer et al, 1996) and none CD31 as endothelial marker.…”

Section: Discussionmentioning

confidence: 99%

“…In doing so, the distribution of distances from random points within the tumour to the closest microvessel are determined. The other computer study measured the morphometry with a quantimet 570 (Bremer et al, 1996). In the present study a digital image analyser for estimating the tumour angiogenesis was used.…”

Section: Discussionmentioning

confidence: 99%

“…These are also the only two studies that used a computer for the analysis of the vascularity. The study by Bremer et al (1996) The current study compared different microvessels counts, percentage of vascular area and vessel perimeter with clinical outcome in a group of patients with a cervical carcinoma. We tried to determine objectively (standardized measurements) which parameters were the most accurate for the prognosis of the patient.…”

Section: Discussionmentioning

confidence: 99%

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Quantification and prognostic relevance of angiogenic parameters in invasive cervical cancer

Tjalma

Marck²,

Weyler³

et al. 1998

Br J Cancer

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Summary Tumour stromal neovascularization was investigated in 114 invasive and 20 in situ carcinomas of the uterine cervix by staining representative sections with the specific endothelial marker anti CD31 (clone JC/70A, isotope IgG1). A digital image analyser was used to measure the immunoreactivity. The following parameters were determined in the 'hot spots': vessel counts, vessel perimeter and endothelial stained area (expressed per mm2). The results were correlated with clinical and histopathological data. There was no significant relationship between the histopathological findings (tumour histology, tumour differentiation, FIGO stage, presence of lymph node metastasis or lymphovascular space involvement) and the median vessel count. In a univariate analysis all angiogenesis parameters had prognostic value: a higher vascularity was associated with worse prognosis (P < 0.05). Multiple regression analysis showed that vascular permeation (P < 0.001) and the median vessel count (P = 0.005) were the most important prognostic indicators. In the future these criteria may be used for selection of patients for anti-angiogenesis therapy.

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Section: Discussionsupporting

confidence: 78%

Section: Digital Image Analysis and Immunohistochemical Evaluationmentioning

confidence: 71%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Quantification and prognostic relevance of angiogenic parameters in invasive cervical cancer

Tjalma

Marck²,

Weyler³

et al. 1998

Br J Cancer

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Tumoural vascularity as a prognostic factor in cancer patients: the evidence continues to grow

1998

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Angiogenesis in endometrial carcinoma

Kaku

Kamura

Kinukawa

et al. 1997

Cancer

101

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BACKGROUND Tumor angiogenesis is essential for tumor growth and metastases. Recently, microvessel density (MVD), a measure of tumor angiogenesis, has been found to have prognostic significance for predicting metastasis and survival in many tumor types. This study was conducted to determine how MVD was related to several clinicopathologic parameters and correlated with metastasis and survival in patients with endometrial carcinoma. METHODS From 1979 through 1989, 85 cases of clinical Stage I and II endometrial carcinomas treated initially by hysterectomy with pelvic lymph node dissection were reviewed histologically. All hysterectomy specimens were stained immunohistologically for factor VIII‐related antigen. MVD was counted in a ×200 field (×20 objective lens and ×10 ocular lens, 0.785 mm2 per field) in the most active area of neovascularization. Results were expressed as the highest number of microvessels identified within any single ×200 field. Statistical analysis included the Mann‐Whitney U test, Kruskal‐Wallis test of variance, and the Spearman rank correlation test. Survival was calculated using the Kaplan‐Meier method and differences in survival were analyzed using the log rank test. MVD and several other prognostic parameters were examined for their correlation with progression free survival (PFS) and overall survival (OS) by a multivariate analysis according to the Cox proportional hazards model. RESULTS MVD was significantly correlated with tumor grade (P = 0.0281), myometrial invasion (P = 0.0282), and lymph‐vascular space invasion (P = 0.0073). There was no correlation between microvessel count and lymph node status and stage. Patients with a high MVD (≥60) had significantly worse PFS and OS than those with a low MVD (<60) (log rank test, P = 0.0116 and P = 0.0096, respectively). Multivariate analysis showed that MVD correlated significantly and independently with PFS and OS. CONCLUSIONS In this study, MVD was found to be an independent prognostic factor for PFS and OS in patients with endometrial carcinoma. Cancer 1997; 80:741‐7. © 1997 American Cancer Society.

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Tumor angiogenesis: An independent prognostic parameter in cervical cancer

Cited by 91 publications

References 16 publications

Quantification and prognostic relevance of angiogenic parameters in invasive cervical cancer

Quantification and prognostic relevance of angiogenic parameters in invasive cervical cancer

Tumoural vascularity as a prognostic factor in cancer patients: the evidence continues to grow

Angiogenesis in endometrial carcinoma

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