2013
DOI: 10.3892/ol.2013.1412
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Tumor angiogenesis, macrophages and mast cell microdensities in endometrioid endometrial carcinoma

Abstract: The present study aimed to observe and compare the values of microvessel density (MVD), mast cell microdensity (McMD) and macrophage microdensity (MphMD) in intratumoral areas compared with the advancing edges, and to assess any correlations between these values and the degree and stage of the neoplasia. The cases of 52 patients who were diagnosed with endometrial carcinoma between 2003 and 2011 were analyzed, the majority of which were in the first stage of the disease (44 cases). Double sequential immunohist… Show more

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Cited by 8 publications
(10 citation statements)
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“…FoxP3+ Tregs were evaluated with the hot spot analysis [ 9 11 ]. The areas of the highest FoxP3+ cell density (hot spots) were located by scanning each tissue section at low (× 50–100) magnification with a Zeiss Axio Lab.A1 (Carl Zeiss, Germany) light microscope, and then either three or five representative areas (depending on the lesion size) were selected and imaged at × 200 magnification.…”
Section: Methodsmentioning
confidence: 99%
“…FoxP3+ Tregs were evaluated with the hot spot analysis [ 9 11 ]. The areas of the highest FoxP3+ cell density (hot spots) were located by scanning each tissue section at low (× 50–100) magnification with a Zeiss Axio Lab.A1 (Carl Zeiss, Germany) light microscope, and then either three or five representative areas (depending on the lesion size) were selected and imaged at × 200 magnification.…”
Section: Methodsmentioning
confidence: 99%
“…Although athymic NCr-nu/nu mice are immunocompromised, lacking thymus gland, and thus do not express T cells, they express tumor-associated macrophages (TAMs) 36 , 37 . The presence of TAMs is necessary for accurate profiling of angiogenesis within the tumor microenvironment as TAMs regulate tumor growth, invasion, metastasis, and angiogenesis 38 – 40 . Tumors size is calculated by measuring the long ( l ) and short ( s ) axis of the ellipsoid tumor with a caliper and applying the following equation: V = s × l 2 .…”
Section: Methodsmentioning
confidence: 99%
“…The stained sections were evaluated independently for tryptase + and chymase + mast cells by counting the number of positive mast cells using a modified hotspot counting method well described previously and published in studies evaluating cell counts [21,22]. The investigator (H.S.)…”
Section: Evaluation Of Stainingsmentioning
confidence: 99%