Tumor angiogenesis: Role in locally aggressive biological behavior of ameloblastoma and keratocystic odontogenic tumor

Gadbail, Amol R.; Gadbail, Mankar; Hande, Alka; Ms, Chaudhary; Gondivkar, Shailesh; Korde, Sheetal; Gawande, Madhuri; Patil, Swati; Tekade, Satyajit Ashok; Sharma, Aditi

doi:10.1002/hed.22960

Cited by 19 publications

(11 citation statements)

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“…The contents of the MRC have been reported to consist of branches of inferior alveolar vessels and nerves ( 1 , 17 ). Histopathological surveys confirm the presence of myelinated nerve fibres associated with numerous venules and an artery ( 17 ).…”

Section: Discussionmentioning

confidence: 99%

“…The mandibular retromolar canal (MRC) is a rare anatomic variation found in the retromolar triangle, a small triangular-shaped region posterior to the third molar tooth in the mandible ( 1 ). Identifying the position and configuration of mandibular canal variations are important in surgical procedures including sagittal split osteotomy, removal of impacted third molars, and implant placement ( 2 ).…”

Section: Introductionmentioning

confidence: 99%

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Diagnostic accuracy of cone-beam CT compared with panoramic images in predicting retromolar canal during extraction of impacted mandibular third molars

Şişman

Ercan-Sekerci²,

Payveren-Arıkan³

et al. 2015

Med Oral

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Objectives: The clinical significance of the existence of a retromolar canal and of its neurovascular content is not yet clear.The aim of the present study was to assess the visibility, diameter and course of the mandibular retromolarcanal (MRC) using cone beam computed tomography (CBCT) scan -had been taken for pre-operative radiographic evaluation of impacted mandibular third molars- compared to panoramic radiographs. Study Design: Subjects eligible for study enrollment were those who underwent preoperative CBCT scan for the extraction of impactedmandibular third molars were determined to be extremely close to the mandibular canal on panoramic radiographs. Radiographs were screened for the presence and course of retromolar canals, and linear measurements. Results: 947hemimandibles in 632 patients were examined.A total of 253 MRCs (144 left, 109 right) were detected with CBCT images (26.7%). Only 29 of these canals were also seen on the corresponding panoramic radiographs. Most MRCs had a vertical course (type VI, 28.46%), followed by slightly curved (type I, 26.09%). The visibility of the MRC on the OPGs, according to the increase in the diameter, was not statistically significant for both sides (p>.05).Statistically difference were found for the width at the point of origin from the mandibular canal (p: .037), the mean distance from the MRC to the second molar (p: .042) and height of MRC when compared the gender. Conclusions: The findings suggest that the MRC isn’t a rare anatomical structure. This study therefore clearly establishes the incidence and importance of the MRC. The detection of the presence of the MRC using CBCT may be crucial for extraction of mandibular third molars. Key words:Accessory innervation, cone beam computed tomography, mandibular anatomy, panoramic radiographs, retromolar canal, retromolar foramen.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Diagnostic accuracy of cone-beam CT compared with panoramic images in predicting retromolar canal during extraction of impacted mandibular third molars

Şişman

Ercan-Sekerci²,

Payveren-Arıkan³

et al. 2015

Med Oral

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“…Compelling data implicate angiogenesis and tumor‐associated neovascularization as a central pathogenic step in the process of tumor growth and invasion [–]. Our immunohistological examination of this odontogenic myxofibroma clearly revealed that CCN2 was highly expressed in microvascular endothelial cells and in the surrounding tumor cells.…”

Section: Discussionmentioning

confidence: 78%

Expression and roles of CCN2 in dental mesenchymal cells in primary culture—With findings in a case of odontogenic myxofibroma

Shimo

Koyama

Horikiri

et al. 2013

Oral Science International

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a b s t r a c tPurpose of the research: Tooth germ development involves multiple events, including cell proliferation and cell differentiation. Connective tissue growth factor (CTGF/CCN2) is a signaling protein involved in tooth germ development, and we investigated how it is expressed and what roles it may have in primary cultures of mesenchymal cells derived from the developing tooth germ. We also examined the expression of CCN2 in a human odontogenic myxofibroma, a benign tumor of odontogenic mesenchymal origin, and considered the possible roles of CCN2 in the development of myxofibromas. Materials and methods: Mesenchymal cells of early bell-stage tooth germs were isolated from Day-90 bovine embryos and placed in primary culture. A resected specimen from a patient with odontogenic myxofibroma was prepared for immunohistochemical studies. Principal results: The CCN2 expression level in proliferating odontogenic mesenchymal cells freshly isolated from the early bell stage of developing bovine tooth germs and placed in primary culture was 3 times higher than that in the confluent non-proliferating cells. Recombinant CCN2 significantly increased the proliferation and type I collagen expression in odontogenic mesenchymal cells in primary culture. Immunohistochemical analysis on myxofibroma case revealed that CCN2 was detectable in MIB-1, a cellular marker of proliferation-positive odontogenic mesenchymal cells adjacent to capillary blood vessels and in the endothelial cells of the vessels in the tumor. Major conclusion: CCN2 signaling would influence the proliferation of and extracellular matrix production by dental mesenchymal cells. Our results suggest that the same mechanisms of CCN2 action toward dental mesenchymal cells would also be operative in the odontogenic myxofibroma microenvironment.

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“…21,22 This complex process, which can be measured by determining the angiogenic index with antibodies against endothelial cell epitopes such as CD34, has been recognized as an important event in the development and progression of odontogenic cysts and tumors, including KOTs. 23,24,25 Although a crucial process in tumor progression, angiogenesis may not accompany the growth of tumor cells, with the consequent emergence of hypoxic areas in the tumor, a fact particularly highlighted in the case of malignant tumors. 26,27 In this respect, neoplastic cells increase the uptake and metabolism of glucose in order to adapt to and survive under the hypoxic conditions of the microenvironment.…”

Section: Introductionmentioning

confidence: 99%

Analysis of GLUT-1, GLUT-3, and angiogenic index in syndromic and non-syndromic keratocystic odontogenic tumors

et al. 2017

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Analysis of GLUT-1, GLUT-3, and angiogenic index in syndromic and non-syndromic keratocystic odontogenic tumors Abstract: The aim of this study was to evaluate the immunoexpression of glucose transporters 1 (GLUT-1) and 3 (GLUT-3) in keratocystic odontogenic tumors associated with Gorlin syndrome (SKOTs) and non-syndromic keratocystic odontogenic tumors (NSKOTs), and to establish correlations with the angiogenic index. Seventeen primary NSKOTs, seven recurrent NSKOTs, and 17 SKOTs were selected for the study. The percentage of immunopositive cells for GLUT-1 and GLUT-3 in the epithelial component of the tumors was assessed. The angiogenic index was determined by microvessel count. The results were analyzed statistically using the nonparametric Kruskal-Wallis test and Spearman's correlation test. High epithelial immunoexpression of GLUT-1 was observed in most tumors (p = 0.360). There was a higher frequency of negative cases for GLUT-3 in all groups. The few GLUT-3-positive tumors exhibited low expression of this protein in epithelial cells. No significant difference in the angiogenic index was observed between groups (p = 0.778). GLUT-1 expression did not correlate significantly with the angiogenic index (p > 0.05). The results suggest that the more aggressive biological behavior of SKOTs when compared to NSKOTs may not be related to GLUT-1 or GLUT-3 expression. GLUT-1 may play an important role in glucose uptake by epithelial cells of KOTs and this process is unlikely related to the angiogenic index. GLUT-1 could be a potential target for future development of therapeutic strategies for KOTs.

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Tumor angiogenesis: Role in locally aggressive biological behavior of ameloblastoma and keratocystic odontogenic tumor

Cited by 19 publications

References 50 publications

Diagnostic accuracy of cone-beam CT compared with panoramic images in predicting retromolar canal during extraction of impacted mandibular third molars

Diagnostic accuracy of cone-beam CT compared with panoramic images in predicting retromolar canal during extraction of impacted mandibular third molars

Expression and roles of CCN2 in dental mesenchymal cells in primary culture—With findings in a case of odontogenic myxofibroma

Analysis of GLUT-1, GLUT-3, and angiogenic index in syndromic and non-syndromic keratocystic odontogenic tumors

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