Tumor-associated macrophages as a potential therapeutic target in thyroid cancers

Zhu, Liya; Li, Xiu Juan; Gangadaran, Prakash; Jing, Xiuli; Ahn, Byeong-Cheol

doi:10.1007/s00262-023-03549-6

Cancer Immunol Immunother

2023

DOI: 10.1007/s00262-023-03549-6

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Tumor-associated macrophages as a potential therapeutic target in thyroid cancers

Liya Zhu,

Xiu Juan Li,

Prakash Gangadaran

et al.

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2024

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Cited by 3 publications

References 223 publications

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Ferroptosis in thyroid cancer: Potential mechanisms, effective therapeutic targets and predictive biomarker

Chen,

Pan,

et al. 2024

Biomedicine & Pharmacotherapy

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Ferroptosis in thyroid cancer: Potential mechanisms, effective therapeutic targets and predictive biomarker

Chen,

Pan,

et al. 2024

Biomedicine & Pharmacotherapy

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Contribution of Cancer-Specific Protein Coronas to the Pro-Tumor Effects of Nanoplastics through Enhanced Cellular Interactions

Tang,

Wang,

et al. 2024

ACS Appl. Mater. Interfaces

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The potential impact of nanoplastics (NPs) on human carcinogenic processes is a matter of growing concern, particularly in light of the global plastic pollution crisis. Although the potential effects of NPs on human health have been well investigated, many uncertainties remain regarding their role in tumor behavior. Upon exposure, NPs can enter the bloodstream and are prone to interacting with plasma proteins to form a protein corona (PC), which can influence their interactions with cancer cells. However, how the PCs adsorbed on NPs affect the particleto-tumor cell interaction and their effect on the tumor biological behavior remain unclear. To better understand the formation of PCs following NPs exposure in the bloodstream under various clinical conditions, we investigated the PC compositions of NPs derived from thyroid cancer (TC) patients and healthy volunteers. Our data revealed a significant enrichment of fibrinogen in the PCs formed on NPs derived from TC patient plasma, which in turn accelerated the endocytosis of NPs into TC cells. In addition, the uptake pathway of NPs into TC cells differed substantially between the two groups studied due to the different PC compositions in cancer patients and healthy individuals. Moreover, intriguingly alterations in the PCs induced by the clinical pathology status were also found to promote NPs engulfment by human macrophages, resulting in potent pro-inflammatory effects, in turn exerting pro-tumor effects. These findings emphasize the importance of considering the significance of a realistic biological identity on NPs and their interactions with cancer cells and also pinpoint the implications of the carcinogenesis outcomes of NPs exposure in humans.

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Immunotherapies Targeting Tumor-Associated Macrophages (TAMs) in Cancer

Li,

Ye,

Luo

2024

Pharmaceutics

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Tumor-associated macrophages (TAMs) are one of the most plentiful immune compositions in the tumor microenvironment, which are further divided into anti-tumor M1 subtype and pro-tumor M2 subtype. Recent findings found that TAMs play a vital function in the regulation and progression of tumorigenesis. Moreover, TAMs promote tumor vascularization, and support the survival of tumor cells, causing an impact on tumor growth and patient prognosis. Numerous studies show that reducing the density of TAMs, or modulating the polarization of TAMs, can inhibit tumor growth, indicating that TAMs are a promising target for tumor immunotherapy. Recently, clinical trials have found that treatments targeting TAMs have achieved encouraging results, and the U.S. Food and Drug Administration has approved a number of drugs for use in cancer treatment. In this review, we summarize the origin, polarization, and function of TAMs, and emphasize the therapeutic strategies targeting TAMs in cancer treatment in clinical studies and scientific research, which demonstrate a broad prospect of TAMs-targeted therapies in tumor immunotherapy.

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Tumor-associated macrophages as a potential therapeutic target in thyroid cancers

Cited by 3 publications

References 223 publications

Ferroptosis in thyroid cancer: Potential mechanisms, effective therapeutic targets and predictive biomarker

Ferroptosis in thyroid cancer: Potential mechanisms, effective therapeutic targets and predictive biomarker

Contribution of Cancer-Specific Protein Coronas to the Pro-Tumor Effects of Nanoplastics through Enhanced Cellular Interactions

Immunotherapies Targeting Tumor-Associated Macrophages (TAMs) in Cancer

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