Tumor-Associated Macrophages Correlate With Prognosis in Medulloblastoma

Zhang, Jin; Yuan, Xiaocong; Wang, Yuan; Liu, Jingjing; Li, Zhigang; Li, Shuting; Liu, Yan; Gong, Xuejun; Sun, Yan; Wu, Wanshui; Sun, Lina; Du, Shuxu; Wang, Tianyou

doi:10.3389/fonc.2022.893132

Cited by 13 publications

(16 citation statements)

References 53 publications

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“…High in ltration of M1 macrophages signi cantly reduced survival time in prostate cancer patients [26]. The M1 macrophage content was signi cantly higher in the metastatic group than in the non-metastatic group of medulloblastoma [34]. Our results also showed that increased CENPO expression was associated with poor LUAD survival.…”

Section: Discussionsupporting

confidence: 56%

Prognostic and immune infiltrative biomarkers of CENPO in pan- cancer and its relationship with lung adenocarcinoma cell proliferation and metastasis

Wang¹,

Liu³

et al. 2023

Preprint

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Background The centromere protein O (CENPO) is an important member of the centromere protein family. However, the role of CENPO in pan–cancer and immune infiltration has not been reported. Here, we investigated the role of CENPO in pan–cancer and further validated its role in lung adenocarcinoma (LUAD) by in vitro experiments. Method The UCSC Xena database and The Cancer Genome Atlas (TCGA)–LUAD data were used to assess the mRNA expression levels of CENPO. The potential value of CENPO as a diagnostic and prognostic biomarker for pan–cancer was evaluated using TCGA data and the GEPIA database. The mRNA expression profiles of LUAD patients and the corresponding clinical data were downloaded for correlation analysis. The role of CENPO in immune infiltration was investigated using the UCSC Xena database. Subsequently, RT–QPCR was performed to detect the expression of CENPO. Cell proliferation, migration, and invasion were determined using CCK–8, wound–healing assay, and transwell assay, respectively. Results CENPO is highly expressed in most cancers, and the upregulation of CENPO is associated with poor prognosis in many cancers. CENPO expression correlates with age, TNM stage, N stage, T stage, and receipt of radiotherapy in LUAD patients, and LUAD patients with high CENPO expression have poorer overall survival (OS) and disease–free survival (DFS). In addition, CENPO expression is associated with immune cell infiltration and immune checkpoint inhibitors. Moreover, the expression of CENPO was closely related to the expression of tumor mutational load and microsatellite instability. In vitro experiments showed that CENPO expression was increased in LUAD cell lines and that knockdown of CENPO significantly inhibited the proliferation, cell invasion, and migration ability of LUAD cells. Conclusion CENPO may be a potential pan–cancer biomarker and oncogene, especially in LUAD. In addition, CENPO is associated with immune cell infiltration and may serve as a new molecular therapeutic target and effective prognostic marker for LUAD.

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Section: Discussionsupporting

confidence: 56%

Prognostic and immune infiltrative biomarkers of CENPO in pan- cancer and its relationship with lung adenocarcinoma cell proliferation and metastasis

Wang¹,

Liu³

et al. 2023

Preprint

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“…The infiltration of tumor-associated macrophages (TAMs) and increased expression of their associated genes, CD163 and CSF1R, were significantly observed in SHH MBs [ 47 ]. An increase in M1 macrophages was reported to correlate with good outcomes of MB [ 48 ]. Furthermore, macrophage reduction in TME were correlated with poorer outcomes of SHH MBs, and TAMs might be involved in inhibiting tumor growth in SHH MBs [ 46 ].…”

Section: Discussionmentioning

confidence: 99%

Clinical and Molecular Features in Medulloblastomas Subtypes in Children in a Cohort in Taiwan

Sung

Huang

et al. 2022

Cancers

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Medulloblastoma (MB) was classified into four molecular subgroups: WNT, SHH, group 3, and group 4. In 2017, 12 subtypes within 4 subgroups and 8 subtypes within non-WNT/non-SHH subgroups according to the differences of clinical features and biology were announced. In this study, we aimed to identify the heterogeneity of molecular features for discovering subtype specific factors linked to diagnosis and prognosis. We retrieved 70 MBs in children to perform RNA sequencing and a DNA methylation array in Taiwan. Integrated with clinical annotations, we achieved classification of 12 subtypes of pediatric MBs in our cohort series with reference to the other reported series. We analyzed the correlation of cell type enrichment in SHH MBs and found that M2 macrophages were enriched in SHH β, which related to good outcomes of SHH MBs. The high infiltration of M2 macrophages may be an indicator of a favorable prognosis and therapeutic target for SHH MBs. Furthermore, C11orf95-RELA fusion was observed to be associated with recurrence and a poor prognosis. These results will contribute to the establishment of a molecular diagnosis linked to prognostic indicators of relevance and help to promote molecular-based risk stratified treatment for MBs in children.

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“…Because TAMs are composed of variable amounts of microglia and macrophages, the composition of TAMs are different in all MB subgroups. Margol et al [ 58 ] and Zhang et al [ 59 ] reported that TAMs were significantly higher in SHH-MB compared to other MB subgroups. This may be due to the high expression of monocyte chemotactic protein-1 (MCP-1], which helps in TAM recruitment and M2 polarization[ 60 ].…”

Section: Introductionmentioning

confidence: 99%

“…Lee et al [ 63 ] suggested that a large number of M1-polarized TAMs was associated with worsening outcome in SHH-MB patients. Lee and his group has also investigated the correlation between TAM recruitment and outcome, and they revealed that expressed M1-polarized TAMs predicted better progression-free survival but, TAMs showed no significant effect on OS[ 59 ]. Few studies showed that the immunoreactivity in MB microenvironment, regardless the subtype, is age-related[ 64 ].…”

Section: Introductionmentioning

confidence: 99%

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Immune microenvironment of medulloblastoma: The association between its molecular subgroups and potential targeted immunotherapeutic receptors

Kurdi¹,

Mulla²,

Malibary³

et al. 2023

World J Clin Oncol

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Medulloblastoma (MB) is considered the commonest malignant brain tumor in children. Multimodal treatments consisting of surgery, radiation, and chemotherapy have improved patients’ survival. Nevertheless, the recurrence occurs in 30% of cases. The persistent mortality rates, the failure of current therapies to extend life expectancy, and the serious complications of non-targeted cytotoxic treatment indicate the need for more refined therapeutic approaches. Most MBs originating from the neurons of external granular layer line the outer surface of neocerebellum and responsible for the afferent and efferent connections. Recently, MBs have been segregated into four molecular subgroups: Wingless-activated (WNT-MB) (Group 1); Sonic-hedgehog-activated (SHH-MB) (Group 2); Group 3 and 4 MBs. These molecular alterations follow specific gene mutations and disease-risk stratifications. The current treatment protocols and ongoing clinical trials against these molecular subgroups are still using common chemotherapeutic agents by which their efficacy have improved the progression-free survival but did not change the overall survival. However, the need to explore new therapies targeting specific receptors in MB microenvironment became essential. The immune microenvironment of MBs consists of distinctive cellular heterogeneities including immune cells and none-immune cells. Tumour associate macrophage and tumour infiltrating lymphocyte are considered the main principal cells in tumour microenvironment, and their role are still under investigation. In this review, we discuss the mechanism of interaction between MB cells and immune cells in the microenvironment, with an overview of the recent investigations and clinical trials

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Tumor-Associated Macrophages Correlate With Prognosis in Medulloblastoma

Cited by 13 publications

References 53 publications

Prognostic and immune infiltrative biomarkers of CENPO in pan- cancer and its relationship with lung adenocarcinoma cell proliferation and metastasis

Prognostic and immune infiltrative biomarkers of CENPO in pan- cancer and its relationship with lung adenocarcinoma cell proliferation and metastasis

Clinical and Molecular Features in Medulloblastomas Subtypes in Children in a Cohort in Taiwan

Immune microenvironment of medulloblastoma: The association between its molecular subgroups and potential targeted immunotherapeutic receptors

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