Tumor-associated tissue eosinophilia and long-term prognosis for carcinoma of the larynx

Thompson, Adrian C.; Bradley, Patrick J.; Griffin, Nicholas R.

doi:10.1016/s0002-9610(05)80102-3

Cited by 51 publications

(41 citation statements)

References 7 publications

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“…Lymphocytic infiltration of an advancing tumor border has been accepted as a sign of host defense and is considered to be a favorable prognostic factor [11,12]. Although our present data reveals a higher incidence (60.0%) of neck metastasis in patients with mild to moderate lymphocytic infiltration of an advancing tumor border than those with marked infiltration (42.9%), this difference was not statistically significant.…”

Section: Discussioncontrasting

confidence: 87%

Histopathological predictors of occult lymph node metastases in supraglottic squamous cell carcinomas

Özdek

Saraç

Akyol

et al. 2000

European Archives of Oto-Rhino-Laryngology

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Lymph node metastasis appears to be the most important factor determining survival in patients with squamous cell carcinoma of the larynx. Supraglottic laryngeal carcinomas have a known tendency to metastasize to cervical lymph nodes because of the extensive lymphatic network present. This retrospective cohort study was conducted to define possible histopathological parameters affecting cervical lymph node metastasis and then using these parameters to create a scale to predict occult lymph node metastasis in supraglottic squamous cell carcinoma. The pathological slides of 61 operated patients were reevaluated for tumor grade, lymphatic-vascular invasion, invasion pattern of tumor margins, perineural invasion and lymphocytic infiltration. Grade (P < 0.001), lymphatic-vascular invasion (P < 0.001) and tumor margins (P = 0.007) were found to be closely associated with neck metastasis. To define the risk factors for occult metastasis, a grading scale was created by using grade (G), lymphatic-vascular invasion (L) and tumor margin (M) findings of patients. None of the patients with a GLM value of zero developed occult metastasis. On the other hand occult metastasis was found in 58.8% of N0 patients with a GLM value that was more than zero. These findings indicate that patients with high-grade tumors having infiltrating borders and lymphatic-vascular invasion have a high risk for occult metastasis so that elective treatment of the neck either by neck dissection or radiotherapy should be added to therapy. Serial sections of specimens are needed to avoid missing metastatic loci of disease.

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Section: Discussioncontrasting

confidence: 87%

Histopathological predictors of occult lymph node metastases in supraglottic squamous cell carcinomas

Özdek

Saraç

Akyol

et al. 2000

European Archives of Oto-Rhino-Laryngology

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“…In particular, eosinophilia of tumour tissue (tumour-associated tissue eosinophilia; TATE) was recognized 100 years ago [34]. The presence of collagenase activity in eosinophils was first reported by Bassett et al [1] in 1976 when they discovered it in the eosinophils of rats.…”

Section: Discussionmentioning

confidence: 99%

Expression of matrix metalloproteinase-1 mRNA related to eosinophilia and interleukin-5 gene expression in head and neck tumour tissue

et al. 1997

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In situ hybridization (ISH) of the expression of matrix metalloproteinase-1 (MMP-1) in areas of local invasion of head and neck tumours was performed. Expression of MMP-1 mRNA was found in stromal inflammatory cells adjacent to the tumour nests, apparently in eosinophils. MMP-1 mRNA expression was seen only in cases with moderate or greater stromal eosinophilia. MMP-1 mRNA was detected in benign papilloma and verrucous carcinoma. In squamous cell carcinomas, expression of the gene was detected only in well-differentiated cases. Expression of MMP-1 mRNA was not related to the grade of malignancy, and appeared in stromal eosinophils, suggesting to us that it is involved in a remodelling process in the reaction of the host to tumour invasion. ISH examination of the expression of interleukin-5 (IL-5), the activating factor for eosinophils, was also performed. In the tumour, its expression was consistent with the location of eosinophils, as with MMP-1 mRNA, suggesting an autocrine mechanism.

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“…It is characterised by the presence of eosinophils as a component of peritumoral and intratumoral inflammatory infiltrate [7, 8]. TATE in malignancies is associated with different sites such as nasopharynx [6, 9], larynx [10, 11], esophagus [12], colon [13, 14], cervix [15], external genitalia [16], skin [17], gastrointestinal tract [18], and oral cavity [7, 8, 16, 19–27]. …”

Section: Introductionmentioning

confidence: 99%

“…It has been related to a favourable and [7, 10, 19, 20] to an unfavourable [15, 21] prognosis or even having no influence on patient outcome [6, 24]. …”

Section: Introductionmentioning

confidence: 99%

Assessment of Tissue Eosinophilia as a Prognosticator in Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma—An Image Analysis Study

Jain

Kasetty

Sudheendra

et al. 2014

Pathology Research International

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Association of tissue eosinophilia with oral squamous cell carcinoma has shown variable results ranging from favourable to unfavourable or even having no influence on prognosis. Also, very few studies have been done to know the role of eosinophils in premalignancy. So the present study investigated role of eosinophilic infiltration in oral precancer and cancer and its possible use as a prognosticator. 60 histopathologically proven cases (20 cases each of metastatic and nonmetastatic oral squamous cell carcinoma and oral leukoplakia with dysplasia of various grades) were included. Congo red is used as a special stain for eosinophils. Each specimen slide was viewed under high power in 10 consecutive microscopic fields for counting of eosinophils. As a result, a significant increase in eosinophil count was found in oral carcinomas compared to dysplasia. Nonmetastatic cases showed higher counts than metastatic carcinomas. So, it is concluded that eosinophilia is a favourable histopathological prognostic factor in oral cancer. Moreover, higher eosinophil counts in carcinoma group compared to dysplasia group proved that they might have a role in stromal invasion thus suggesting that quantitative assessment of tissue eosinophilia should become a part of the routine histopathological diagnosis for oral precancer and OSCC.

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Tumor-associated tissue eosinophilia and long-term prognosis for carcinoma of the larynx

Cited by 51 publications

References 7 publications

Histopathological predictors of occult lymph node metastases in supraglottic squamous cell carcinomas

Histopathological predictors of occult lymph node metastases in supraglottic squamous cell carcinomas

Expression of matrix metalloproteinase-1 mRNA related to eosinophilia and interleukin-5 gene expression in head and neck tumour tissue

Assessment of Tissue Eosinophilia as a Prognosticator in Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma—An Image Analysis Study

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