Tumor-Associated Tissue Eosinophilia as a Prognostic Factor in Squamous Cell Carcinoma of the Larynx

Etıt, Demet; Yardim, Bengü Günay; Arslanoğlu, Seçil; Bayol, Ümit; Çukurova, İbrahim; Öztürkcan, Sedat; Korkmaz, Nılay Şen

doi:10.1007/s12070-011-0417-1

Cited by 7 publications

(3 citation statements)

References 16 publications

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“…5b ). Multiple studies have shown an improved prognosis with tumor-associated tissue eosinophilia in various types of SCCs, including oral SCCs 57 , 58 , esophageal SCCs 59 , nasopharyngeal SCCs 60 , and penile cancer 61 .…”

Section: Resultsmentioning

confidence: 99%

Proteomic analysis reveals key differences between squamous cell carcinomas and adenocarcinomas across multiple tissues

et al. 2022

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Squamous cell carcinoma (SCC) and adenocarcinoma (AC) are two main histological subtypes of solid cancer; however, SCCs are derived from different organs with similar morphologies, and it is challenging to distinguish the origin of metastatic SCCs. Here we report a deep proteomic analysis of 333 SCCs of 17 organs and 69 ACs of 7 organs. Proteomic comparison between SCCs and ACs identifies distinguishable pivotal pathways and molecules in those pathways play consistent adverse or opposite prognostic roles in ACs and SCCs. A comparison between common and rare SCCs highlights lipid metabolism may reinforce the malignancy of rare SCCs. Proteomic clusters reveal anatomical features, and kinase-transcription factor networks indicate differential SCC characteristics, while immune subtyping reveals diverse tumor microenvironments across and within diagnoses and identified potential druggable targets. Furthermore, tumor-specific proteins provide candidates with differentially diagnostic values. This proteomics architecture represents a public resource for researchers seeking a better understanding of SCCs and ACs.

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Section: Resultsmentioning

confidence: 99%

Proteomic analysis reveals key differences between squamous cell carcinomas and adenocarcinomas across multiple tissues

et al. 2022

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“…The term TATE was suggested at first by Lowe et al in 1981 [4] to indicate the presence of eosinophils in tumor stroma recruited under the influence of chemicals or other immune cells, in the absence of any ulceration or necrosis [56,57]. TATE has been documented in several neoplasms in human medicine, such as oral squamous cell carcinoma (SCC) [58], solid tumors, bladder cancer [18], larynx SCC [59], esophageal SCC [60], colorectal cancer [61], cervical carcinoma [62], gastric adenocarcinoma [63], nasopharyngeal carcinoma [64], Hodgkin lymphoma [65], and penile cancer [13]. The presence of eosinophils in MCT is due to mast-cell-released eosinophil chemoattractant factors (such as histamine, stem cell factor, and interleukin 5) [66]; however, there are no studies testing the potential prognostic power of the degree of eosinophils infiltrates in MCTs.…”

Section: Discussionmentioning

confidence: 99%

Preliminary Assessment of Tumor-Associated Tissue Eosinophilia (TATE) in Canine Mast Cell Tumors: Prevalence and Prognostic Relevance and Its Association with Neoangiogenesis

Galietta

Parisi

Cocumelli

et al. 2023

Animals

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Mast cell tumor (MCT) is the most common malignant skin tumor in dogs. In order to gain more information on the prognostic markers in MCT, the role of the eosinophil granulocytes infiltrates was investigated and assessed by the evaluation of tumor-associated tissue eosinophilia (TATE) in 87 canine cutaneous MCTs. In human medicine, high TATE are often described in highly angiogenic tumors: we therefore assessed the vascular endothelial growth factor (VEGF) expression in neoplastic mast cells. TATE and VEGF expression were compared between themselves, with histological grading, immunohistochemical expression of KIT and Ki-67, and with the recurrence. We found a statistically significant correlation between TATE and Patnaik grading (p = 0.041), Kiupel grading (p = 0.022), immunohistochemical KIT expression (p = 0.015), and tumor recurrence (p = 0.000). No associations were observed with Ki-67 and VEGF expression. This is the first evaluation of TATE and its prognostic value in canine MCTs in veterinary oncology. This study suggest that this investigation could be an important source of information for this tumor and for other neoplasms.

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“…TATE has been reported in various organs, including the oral cavity, esophagus, larynx, bile duct, lung, gastrointestinal tract, genitourinary tract, and other rare sites. 3–11 Many reported cases of TATE are often associated with squamous cell carcinoma (SqCC), but there are also reports of adenocarcinoma-, urothelial carcinoma-, and large cell carcinoma-induced TATE. To our knowledge, however, no studies have examined the detailed cytological findings of TATE.…”

Section: Introductionmentioning

confidence: 99%

Adenosquamous carcinoma of the uterine cervix displaying tumor-associated tissue eosinophilia

Kurose

Mizuguchi

Ohkanemasa

et al. 2019

SAGE Open Medical Case Reports

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Background:Tumor-associated tissue eosinophilia is defined as an inflammatory response with the marked infiltration of eosinophils within tumor tissues. Tumor-associated tissue eosinophilia has been reported in various organs; however, no studies have examined the detailed cytopathological findings of tumor-associated tissue eosinophilia.Case Presentation:A 49-year-old woman presented with lower abdominal and back pain that had started 1 month earlier. A cervical biopsy revealed a diagnosis of non-keratinizing squamous cell carcinoma. A mildly increased number of eosinophils was observed in both cervical cytology and a biopsy. On pelvic computed tomography, a tumor mass measuring up to 5.5 cm in the largest diameter was seen in the uterine cervix. After 1 month, endometrial cytology was performed, and non-keratinizing squamous cell carcinoma together with normal endometrial glands was obtained in a background of marked eosinophil numbers. Tumor cells in an irregular-shaped solid nest had variable-sized hyperchromatic nuclei and light-green-stained cytoplasm. The number of eosinophils was obviously increased. Considering the possibility of tumor-associated tissue eosinophilia, we evaluated a peripheral blood sample and confirmed an increased number of eosinophils. Radical hysterectomy was performed, and the final pathological diagnosis was adenosquamous carcinoma. Although the number of eosinophils decreased after surgery, it increased again at the time of recurrence 1 year later. Chemo-irradiation was performed, but the patient died 1 year and 8 months after the operation.Conclusion:Cytopathologists should consider the presence of tumor-associated tissue eosinophilia by focusing on not only tumor cells but also the markedly eosinophilic background. The eosinophil count might be a useful marker of the disease activity.

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Tumor-Associated Tissue Eosinophilia as a Prognostic Factor in Squamous Cell Carcinoma of the Larynx

Cited by 7 publications

References 16 publications

Proteomic analysis reveals key differences between squamous cell carcinomas and adenocarcinomas across multiple tissues

Proteomic analysis reveals key differences between squamous cell carcinomas and adenocarcinomas across multiple tissues

Preliminary Assessment of Tumor-Associated Tissue Eosinophilia (TATE) in Canine Mast Cell Tumors: Prevalence and Prognostic Relevance and Its Association with Neoangiogenesis

Adenosquamous carcinoma of the uterine cervix displaying tumor-associated tissue eosinophilia

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