Tumor cell-derived exosomes deliver TIE2 protein to macrophages to promote angiogenesis in cervical cancer

Du, Shi; Qian, Jiaxian; Tan, Shuran; Li, Wenhan; Liu, Pan; Zhao, Jing; Zeng, Yue; Xu, Leqin; Wang, Zehua; Cai, Jing

doi:10.1016/j.canlet.2022.01.005

Cited by 58 publications

(30 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The frequency of PD-1 + M2 macrophages was more abundant in cervical cancer tissue than in non-cancerous cervical tissue, suggesting the possibility that PD-1 + macrophages might play some important roles in the progression of cervical cancer. Increasing evidence suggested that targeting macrophage polarization bene ts cervical cancer treatment (21,22). PD-1 was rst discovered as a molecule expressed on T cells that induced apoptosis of T cells (23).…”

Section: Discussionmentioning

confidence: 99%

Glycolysis induced by METTL14-related m6A methylation is essential for macrophage function and tumor progression in cervical cancer

Wang

Jiao

Zhang

et al. 2022

Preprint

View full text Add to dashboard Cite

Cervical cancer is one of the most common tumors of women’s diseases. N6-methyladenosine (m6A) is an abundant RNA modification of mammalian mRNAs and plays a vital role in many diseases, especially tumors. In this study, we aimed to investigate the roles of m6A on macrophage function and tumor progression in cervical cancer. We measured the levels of m6A expression in cervical cancer tissues, and revealed biological functions of METTL14 (Methyltransferase14, N6-Adenosine-Methyltransferase Subunit) on tumor-associated macrophages (TAMs) and PD-1 expression. We found the METTL14-related methylation of m6A in cervical cancer was correlated with infiltration of TAMs, polarization status of infiltrated TAMs, and survival outcomes of cervical cancer patients. Mechanistically, lactate produced by tumor glycolysis in the acidic immunosuppressive tumor microenvironment (TME) has an important role as a proinflammatory and immunosuppressive mediator in this program. METTL14-related methylation of m6A may play a predictive role in the polarization and PD-1 expression of macrophages in TME. The study intends to reveal the effect of m6A on the immune microenvironment and macrophage differentiation of cervical cancer, which could be a viable therapeutic target for the treatment of advanced human cancers.

show abstract

Section: Discussionmentioning

confidence: 99%

Glycolysis induced by METTL14-related m6A methylation is essential for macrophage function and tumor progression in cervical cancer

Wang

Jiao

Zhang

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…TEXs are rich in protein, miRNA, mRNA, DNA, and lipid contents and play an essential role in the early diagnosis, development, and treatment of tumors [138][139][140]. However, because of the differences in experimental materials and research methods, the detection of single exosome contents is prone to false-positive results.…”

Section: Future Prospections and Conclusionmentioning

confidence: 99%

Tumor-derived small extracellular vesicles: potential roles and mechanism in glioma

2022

View full text Add to dashboard Cite

Small extracellular vesicles (SEVs) are extracellular vesicles containing DNA, RNA, and proteins and are involved in intercellular communication and function, playing an essential role in the growth and metastasis of tumors. SEVs are present in various body fluids and can be isolated and extracted from blood, urine, and cerebrospinal fluid. Under both physiological and pathological conditions, SEVs can be released by some cells, such as immune, stem, and tumor cells, in a cytosolic manner. SEVs secreted by tumor cells are called tumor-derived exosomes (TEXs) because of their origin in the corresponding parent cells. Glioma is the most common intracranial tumor, accounting for approximately half of the primary intracranial tumors, and is characterized by insidious onset, high morbidity, and high mortality rate. Complete removal of tumor tissues by surgery is difficult. Chemotherapy can improve the survival quality of patients to a certain extent; however, gliomas are prone to chemoresistance, which seriously affects the prognosis of patients. In recent years, TEXs have played a vital role in the occurrence, development, associated immune response, chemotherapy resistance, radiation therapy resistance, and metastasis of glioma. This article reviews the role of TEXs in glioma progression, drug resistance, and clinical diagnosis.

show abstract

“…Angiopoietins, which regulate vascular development and are essential for vascular remodelling in inflammatory conditions and tumour angiogenesis, are regulated by a receptor known as tyrosine kinase with immunoglobulin and epidermal growth factor homology 2 (TIE2). Duet et al [52] discovered that CC cell-derived exosomes deliver TIE2 protein to macrophages, which induces the formation of TIE2-expressing macrophages (TEMs) to promote CC angiogenesis. By upregulating hedgehog-GLI signalling, CC exosomes also encourage angiogenesis in human umbilical vein endothelial cells (HUVECs), and exosomes from HPV-positive (SiHa and HeLa) cells are more angiogenic [53].…”

Section: Exosomes Derived From Cellsmentioning

confidence: 99%

Advances in Exosomes as Diagnostic and Therapeutic Biomarkers for Gynaecological Malignancies

Miao

Zhu

et al. 2022

Cancers

View full text Add to dashboard Cite

Background: Exosomes are extracellular vesicles that can be released by practically all types of cells. They have a diameter of 30–150 nm. Exosomes control the exchange of materials and information between cells. This function is based on its special cargo-carrying and transporting functions, which can load a variety of useful components and guarantee their preservation. Recently, exosomes have been confirmed to play a significant role in the pathogenesis, diagnosis, treatment, and prognosis of gynaecological malignancies. Particularly, participation in liquid biopsy was studied extensively in gynaecological cancer, which holds the advantages of noninvasiveness and individualization. Literature Review: This article reviews the latest research progress of exosomes in gynaecological malignancies and discusses the involvement of humoral and cell-derived exosomes in the pathogenesis, progression, metastasis, drug resistance and treatment of ovarian cancer, cervical cancer, and endometrial cancer. Advances in the clinical application of exosomes in diagnostic technology, drug delivery, and overcoming tumour resistance are also presented. Conclusion: Exosomes are potentially diagnostic and prognostic biomarkers in gynaecological malignancies, and also provide new directions for the treatment of gynaecological tumours, showing great clinical potential.

show abstract

Tumor cell-derived exosomes deliver TIE2 protein to macrophages to promote angiogenesis in cervical cancer

Cited by 58 publications

References 41 publications

Glycolysis induced by METTL14-related m6A methylation is essential for macrophage function and tumor progression in cervical cancer

Glycolysis induced by METTL14-related m6A methylation is essential for macrophage function and tumor progression in cervical cancer

Tumor-derived small extracellular vesicles: potential roles and mechanism in glioma

Advances in Exosomes as Diagnostic and Therapeutic Biomarkers for Gynaecological Malignancies

Contact Info

Product

Resources

About