Tumor cell-targeting radiotherapy in the treatment of glioblastoma multiforme using linear accelerators

Chiang, Chih Sheng; Shih, I-Ju; Shueng, Pei‐Wei; Kao, Min; Zhang, Liwen; Chen, Shuo-Fu; Chen, Minghong; Liu, Tse Ying

doi:10.1016/j.actbio.2021.02.019

Cited by 17 publications

(18 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…450 However, more studies and optimization are needed to use this platform in clinical therapy. 448,451 Etame et al systematically studied the permeation of AuNPs with a surface functionalized with PEG through the brain microvasculature. Their studies suggested a way to design AuNPs for passive targeting of GBM.…”

Section: Nanodelivery Vehicles Using Gnss (Drugs Biomolecules and Genes)mentioning

confidence: 99%

See 1 more Smart Citation

Gold nanostructures: synthesis, properties, and neurological applications

Zare¹,

Yaraki

Speranza

et al. 2022

Chem. Soc. Rev.

View full text Add to dashboard Cite

show abstract

Section: Nanodelivery Vehicles Using Gnss (Drugs Biomolecules and Genes)mentioning

confidence: 99%

“…450 However, more studies and optimization are needed to use this platform in clinical therapy. 448,451…”

Section: Nanodelivery Vehicles Using Gnss (Drugs Biomolecules and Genes)mentioning

confidence: 99%

Gold nanostructures: synthesis, properties, and neurological applications

Zare¹,

Yaraki

Speranza

et al. 2022

Chem. Soc. Rev.

View full text Add to dashboard Cite

show abstract

“…A variety of therapeutic approaches have been developed to treat glioblastoma multiforme and differ in terms of targeting either the tumor cells or enhancing the anti-cancer immune response; many factors influence the choice for the most suitable option in each cancer patient, which can be influenced by either tumor-associated factors or patient-and physician-associated factors. However, the ultimate goal of all treatments is to eradicate the glioblastoma multiforme cells, minimize the sequelae of treatment, preserve or restore form and function, and prevent any potential subsequent primary cancers [37][38][39] . Table 1 presents a summary of the current therapeutic options for glioblastoma multiforme.…”

Section: Therapeutic Approaches Of Glioblastoma Multiformementioning

confidence: 99%

Novel Insights into Genetic Approaches in Glioblastoma Multiforme Therapy

et al. 2022

View full text Add to dashboard Cite

Glioblastoma multiforme is one of the most common and malignant types of central nervous system (CNS) tumors. Despite the great advances in treatment modalities and the variety of therapeutic options, it remains largely incurable with continuously growth incidence, due to the genomic instability of glioblastoma multiforme cells, their heterogeneity, and their resistance to chemo-and radiotherapies. The aggressive behavior of these brain tumors and their sequestered location behind the blood-brain barrier restricts the role of the immune system. Great success has been made recently in glioblastoma multiforme treatment using genetic based approaches to selectively target cancerous cells and restore tumor suppressor gene expression or silence specific oncogenes to prevent their expression. The use of genetic approaches has attracted more interest and research and has revealed their ability to regulate the expression of glioblastoma multiforme oncogenes without changing the genotype and thus avoiding possible genotoxicity. This review delivers an overview of glioblastoma multiforme cell biology, tumorigenesis, and immune surveillance, and discusses recent advances in genetic based therapies of glioblastoma multiforme.

show abstract

“…Additional studies explored strategies that may further enhance radiation-induced immune response [ 125 , 126 , 127 , 128 ]. Bielecki et al found that immunostimulatory mesoporous silica nanoparticles could deliver a stimulator of interferon genes (STING) agonist to the tumor microenvironment that reversed immunosuppression [ 126 ].…”

Section: Combining Immunotherapy and Radiotherapymentioning

confidence: 99%

“…Bielecki et al found that immunostimulatory mesoporous silica nanoparticles could deliver a stimulator of interferon genes (STING) agonist to the tumor microenvironment that reversed immunosuppression [ 126 ]. Chiang et al developed targeted sensitization-enhanced radiotherapy (TSER) that utilized GoldenDisk as a radioenhancer and achieved selective and sustained radiosensitization effects in CD44-expressing GBM cells [ 127 ]. Chen et al synthesized a gold-based outer-membrane vesicle (OMV) that could produce radiosensitizing and immunomodulatory effects when combined with RT [ 128 ].…”

Section: Combining Immunotherapy and Radiotherapymentioning

confidence: 99%

Treatment of Brain Metastases: The Synergy of Radiotherapy and Immune Checkpoint Inhibitors

et al. 2022

View full text Add to dashboard Cite

Brain metastases are a devastating sequela of common primary cancers (e.g., lung, breast, and skin) and have limited effective therapeutic options. Previously, systemic chemotherapy failed to demonstrate significant benefit in patients with brain metastases, but in recent decades, targeted therapies and more recently immune checkpoint inhibitors (ICIs) have yielded promising results in preclinical and clinical studies. Furthermore, there is significant interest in harnessing the immunomodulatory effects of radiotherapy (RT) to synergize with ICIs. Herein, we discuss studies evaluating the impact of RT dose and fractionation on the immune response, early studies supporting the synergistic interaction between RT and ICIs, and ongoing clinical trials assessing the benefit of combination therapy in patients with brain metastases.

show abstract

Tumor cell-targeting radiotherapy in the treatment of glioblastoma multiforme using linear accelerators

Cited by 17 publications

References 33 publications

Gold nanostructures: synthesis, properties, and neurological applications

Gold nanostructures: synthesis, properties, and neurological applications

Novel Insights into Genetic Approaches in Glioblastoma Multiforme Therapy

Treatment of Brain Metastases: The Synergy of Radiotherapy and Immune Checkpoint Inhibitors

Contact Info

Product

Resources

About