Tumor de células granulares. Estudio clínico de 81 pacientes

Marcoval, Joaquim; Bauer-Alonso, Andrea; Llobera-Ris, Clàudia; Moreno-Vílchez, Carlos; Penín, R.M.; Bermejo, Josep Oriol

doi:10.1016/j.ad.2020.11.012

Cited by 14 publications

(10 citation statements)

References 13 publications

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“…In terms of location, in order of frequency, they can be found at the level of the tongue (the most common) followed by the torso and limbs ( 5 ). Most of the time the tumor is solitary, but there can be multiple foci, including in the internal organs, with the percentage of multiple localizations reaching, according to some studies, up to 30% of cases ( 4 ).…”

Section: Discussionmentioning

confidence: 99%

“…Multiple localizations in adults have been associated with some diseases such as neurofibromatosis and Hodgkin's lymphoma ( 4 ), and in children, they have been associated with cryptorchidism, pulmonary stenosis, congenital heart disease, or Noonan syndrome ( 14 ). Noonan syndrome is part of a group of diseases called RASopathies , characterized by genetic mutations in RAS proteins, that play an important role in cell differentiation and development, comprising Noonan syndrome and neurofibromatosis, Legius syndrome, and Costello syndrome and Leopard (PTPN1 gene mutation) ( 5 , 15 ). Extracutaneous localization may affect the mammary gland, mediastinum, thyroid, larynx and trachea, lungs, ovary, testicle, heart, digestive tract, urinary tract, and rarely the central nervous system, but the central nervous system has the most severe clinical manifestations ( 1 ).…”

Section: Discussionmentioning

confidence: 99%

“…Clinically, it manifests as a round, painless, skin-colored tumor, located subcutaneously, with slow growth, with somewhat unclear margins, measuring between 5 mm and 10 cm in diameter, sometimes with a warty appearance due to epidermal hyperplasia ( 5 , 6 , 17 ). As the tumor affects the innervation of the skin, sometimes skin contractions occur.…”

Section: Discussionmentioning

confidence: 99%

“…However, 2% of Abrikossoff tumors can be malignant ( 4 ). There is no predisposition for a certain sex although they can be found at all ages, and they predominate between the fourth and sixth decades of life ( 1 , 5 ).…”

Section: Introductionmentioning

confidence: 99%

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Case report: Abrikossoff's tumor of the facial skin

et al. 2023

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Abrikossoff tumors, also known as granular cell tumors (GCT), originate from Schwann cells. The most common location is in the oral cavity, followed by the skin, but they can also be found in the breast, digestive tract, tracheobronchial tree, or central nervous system. They can affect both sexes at any age, with a higher incidence between 30 and 50 years and a slight predisposition for female sex. They are usually solitary tumors but may also be multifocal. Most of the time, they are benign, with malignancy being exceptional in <2% of cases. Clinically, they appear as solid, well-defined, painless tumors, located subcutaneously with dimensions that can reach up to 10 cm. The definitive diagnosis is based on the immunohistochemical examination, and the treatment for benign tumors consists of surgical excision. Chemotherapy or radiotherapy may be required for malignant lesions, but the treatment regimens and their benefits remain unclear. This manuscript presents the case of a 12-year-old girl with a benign GCT, located in the skin on the mandibular line.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Case report: Abrikossoff's tumor of the facial skin

et al. 2023

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“…Existe cierta controversia en relación con su origen debido a la existencia de una variante de tumor de células granulares que no expresa S-100 y que sobreexpresan ALK y ciclina D1, y posiblemente suponen una entidad distinta. (6) En cuanto a su localización, la zona de presentación más frecuente es la cavidad oral y la piel (suponen un 66% de los casos), aunque se han descrito en múltiples localizaciones como la vulva, el tracto digestivo o el pulmón. Suelen presentarse entre la cuarta y la sexta década de la vida, con una incidencia superior en mujeres.…”

Section: Discussionunclassified

Tumor de células granulares de vejiga: presentación de un raro hallazgo y revisión de la literatura

2023

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Descripción del caso: Varón de 68 años con un cuadro de síndrome constitucional secundario a un absceso en el psoas, que en el TAC se le diagnosticó incidentalmente una posible lesión neoplásica. En la cistoscopia se identifica una neoformación polipoide que se extirpa en su totalidad mediante resección transuretral, siendo diagnosticada de tumor de células granulares de vejiga. Relevancia: El tumor de células granulares es una neoplasia poco frecuente, con tan solo 27 casos en vejiga descritos. Estas lesiones son mayoritariamente benignas, aunque han sido descritos casos de naturaleza maligna. Debido a su presentación de forma asintomática, existe un infradiagnóstico de estas lesiones, que se traduce en la falta de información clínica y terapéutica, sin la existencia de guías para su manejo. Implicaciones clínicas: Es importante conocer las características clínicas e histológicas de esta patología porque su clínica puede ser similar a la de algunas neoplasias de la vejiga; también es importante conocer la entidad para llevar a cabo un correcto tratamiento, teniendo en cuenta su característica tendencia a la recurrencia. Conclusión: A pesar de ser lesiones infrecuentes, debido a su tendencia a la recurrencia y a su posible naturaleza maligna es importante tenerlas en cuenta.

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