2022
DOI: 10.21203/rs.3.rs-1755087/v1
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Tumor-derived Exosomal LncRNA SNHG16 Induces Telocytes to promote metastasis of hepatocellular carcinoma via miR-942-3p/MMP9 axis

Abstract: Background: Hepatocellular carcinoma(HCC) cells-derived exosomal LncRNA SNHG16(LncSNHG16) is highly expressed and associated with the poor overall survival of patients. Telocytes(TCs), as novel interstitial cells, possess the function to promote HCC metastasis. Therefore, whether a molecular interaction between exosomal LncSNHG16 and TCs will be revealed in our study.Methods: LncSNHG16 expression in HCC tissues and cell lines were detected, and its bioinformatics analysis was screened. Exosomes were isolated a… Show more

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