Tumor-derived exosomal miR-619-5p promotes tumor angiogenesis and metastasis through the inhibition of RCAN1.4

Kim, Dong Ha; Park, Sojung; Kim, HyeongRyul; Choi, Yun Jung; Kim, Seon Ye; Sung, Kyung Jeh; Sung, Young Hoon; Choi, Chang‐Min; Yun, Miyong; Yi, Young-Su; Lee, Chae Won; Kim, Sangjin; Lee, Jae Cheol; Rho, Jin Kyung

doi:10.1016/j.canlet.2020.01.023

Cited by 83 publications

(56 citation statements)

References 39 publications

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“…The rich vascular network in TME is beneficial to the proliferation and metastasis of cancer cells. Exosomal miR-619-5p inhibits the expression of RCAN1.4, promotes angiogenesis, and facilitates the growth and metastasis of cancer cells [128]. Recent studies have shown that circulating exosomal miR-205 expression is elevated in OC patients and is related to microvessel density, and exosomal miR-205 induces angiogenesis via the PTEN-AKT pathway, and promotes tumor cell proliferation in vitro [129].…”

Section: Promoting Angiogenesis To Enhance Proliferation and Migrationmentioning

confidence: 99%

Exosomal miRNAs in tumor microenvironment

Tan

Xia

et al. 2020

J Exp Clin Cancer Res

138

117

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Tumor microenvironment (TME) is the internal environment in which tumor cells survive, consisting of tumor cells, fibroblasts, endothelial cells, and immune cells, as well as non-cellular components, such as exosomes and cytokines. Exosomes are tiny extracellular vesicles (40-160nm) containing active substances, such as proteins, lipids and nucleic acids. Exosomes carry biologically active miRNAs to shuttle between tumor cells and TME, thereby affecting tumor development. Tumor-derived exosomal miRNAs induce matrix reprogramming in TME, creating a microenvironment that is conducive to tumor growth, metastasis, immune escape and chemotherapy resistance. In this review, we updated the role of exosomal miRNAs in the process of TME reshaping.

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Section: Promoting Angiogenesis To Enhance Proliferation and Migrationmentioning

confidence: 99%

Exosomal miRNAs in tumor microenvironment

Tan

Xia

et al. 2020

J Exp Clin Cancer Res

138

117

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show abstract

“…Therefore, exosomes are not only important carriers of bioactive substances, but also crucial mediators for information exchange between cells (7,8). It has been demonstrated that exosomes can transmit biological information by transporting coated contents, such as microRNAs (miRNAs), long non-coding RNAs (lncRNAs) and proteins, and participate in the malignant processes of NSCLC through various pathways (9,10). miRNAs are a family of small non-coding RNAs that can alter gene expression post-transcriptionally, thereby regulating tumor cell proliferation, migration, invasion and metastasis, angiogenesis and apoptosis as well as genomic instability (11,12).…”

Section: Introductionmentioning

confidence: 99%

Downregulation of exosomal miR‑1273a increases cisplatin resistance of non‑small cell lung cancer by upregulating the expression of syndecan binding protein

Zhao

Dai

et al. 2020

Oncol Rep

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Resistance to platinum-based drugs, such as cisplatin (CDDP), has been one of the major factors adversely affecting the clinical prognosis of patients with advanced non-small cell lung cancer (NSCLC). While it has been demonstrated that dysregulation of microRNAs (miRNAs) may contribute to cisplatin resistance in NSCLC, the underlying mechanisms remain largely unclear. In the present study, the effect of exosomal miR-1273a on cisplatin sensitivity of NSCLC was investigated. Microarray analysis was conducted to analyze the miRNA expression profiles in exosomes isolated from A549 cells treated with or without CDDP, and miR-1273a was found to be the most prominently downregulated miRNA in CDDP-treated exosomes. Overexpression of miR-1273a significantly increased the cytotoxicity of CDDP and induced apoptosis in A549 cells. Syndecan binding protein (SDCBP) was predicted to be a direct target of miR-1273a by bioinformatics and was found to be downregulated by miR-1273a in A549 cells. Furthermore, decreased plasma exosomal miR-1273a and increased plasma SDCBP levels were found to be associated with worse therapeutic outcomes of patients with advanced NSCLC receiving platinum-based chemotherapy. These findings suggest that miR-1273a is closely associated with the development of cisplatin resistance and may serve as a potential prognostic biomarker and therapeutic target for NSCLC.

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“…The expression of miR-1273f was signi cantly elevated within exosomes released by hypoxic hepatocellular carcinoma cells than that by normoxic cells, and it could activate the Wnt/β-catenin signaling pathway 29 . Meanwhile, the exosome and plasma levels of miR-619-5p were signi cantly higher in non-small cell lung cancer 30 and prostate cancer cases 31 than in the HCs, whereas the expression level of miR-619-5p was signi cantly lower in colorectal cancer tissues than in normal tissues 32 . Furthermore, miR-150-3p reportedly has diverse expression patterns, in which miR-150 was up-regulated in gastric cancer tissues 33 but down-regulated in lung adenocarcinoma tissues compared with that in normal tissues 34 .…”

Section: Discussionmentioning

confidence: 92%

Urinary MicroRNA Biomarkers for Detecting The Presence of Esophageal Cancer

Okuda

Shimura

Iwasaki

et al. 2020

Preprint

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Background: Esophageal cancer (EC) including esophageal squamous cell carcinoma (ESCC) and adenocarcinoma (EAC) generally exhibits poor prognosis; hence, a noninvasive biomarker enabling early detection is necessary. Methods: Age- and sex-matched 150 healthy controls (HCs) and 43 patients with ESCC were randomly divided into two groups: 9 patients in the discovery cohort for microarray analysis and 184 patients in the training/test cohort with cross-validation for qRT-PCR analysis. Using 152 urine samples (144 HCs and 8 EACs), we validated the urinary miRNA biomarkers for EAC diagnosis.Results: Among eight miRNAs selected in the discovery cohort, urinary levels of five miRNAs (miR-1273f, miR-619-5p, miR-150-3p, miR-4327, and miR-3135b) were significantly higher in the ESCC group than in the HC group, in the training/test cohort. Consistently, these five urinary miRNAs were significantly different between HC and ESCC in both training and test sets. Especially, urinary miR-1273f and miR-619-5p showed excellent values of area under the curve (AUC) ≥ 0.80 for diagnosing stage I ESCC. Similarly, the EAC group had significantly higher urinary levels of these five miRNAs than the HC group, with AUC values of approximately 0.80.Conclusion: The present study established novel urinary miRNA biomarkers that can early detect ESCC and EAC.

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Tumor-derived exosomal miR-619-5p promotes tumor angiogenesis and metastasis through the inhibition of RCAN1.4

Cited by 83 publications

References 39 publications

Exosomal miRNAs in tumor microenvironment

Exosomal miRNAs in tumor microenvironment

Downregulation of exosomal miR‑1273a increases cisplatin resistance of non‑small cell lung cancer by upregulating the expression of syndecan binding protein

Urinary MicroRNA Biomarkers for Detecting The Presence of Esophageal Cancer

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