Tumor-derived exosomes encapsulating miR-34a promote apoptosis and inhibit migration and tumor progression of colorectal cancer cells under in vitro condition

Hosseini, Maryam Sadat; Baghaei, Kaveh; Amani, Davar; Ebtekar, Massoumeh

doi:10.1007/s40199-021-00400-0

Cited by 24 publications

(11 citation statements)

References 57 publications

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“…Han et al (2021) found that sEVs loaded with anti-miRNA-221 oligonucleotides were taken up by colon cancer cells through NRP-1 protein and downregulated caco2 and HCT116 in CRC cells, which could inhibit CRC cell proliferation. In addition, sEVs isolated from starved CT-26 cells delivered miR-34a to tumor cells and were able to induce apoptosis and inhibit the migration of CRC cells (Hosseini et al, 2021). It was also found that overexpression of miR-193a, which inhibits CRC cell proliferation, along with downregulation of let-7g, can improve survival rates (Cho et al, 2021).…”

Section: Inhibit Cancer Cell Proliferation and Promote Apoptosis Of C...mentioning

confidence: 99%

Progress of regulatory RNA in small extracellular vesicles in colorectal cancer

Zhou

et al. 2023

Front. Cell Dev. Biol.

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Colorectal cancer (CRC) is the second most common malignant tumor of the gastrointestinal tract with the second highest mortality rate and the third highest incidence rate. Early diagnosis and treatment are important measures to reduce CRC mortality. Small extracellular vesicles (sEVs) have emerged as key mediators that facilitate communication between tumor cells and various other cells, playing a significant role in the growth, invasion, and metastasis of cancer cells. Regulatory RNAs have been identified as potential biomarkers for early diagnosis and prognosis of CRC, serving as crucial factors in promoting CRC cell proliferation, invasion and metastasis, angiogenesis, drug resistance, and immune cell differentiation. This review provides a comprehensive summary of the vital role of sEVs as biomarkers in CRC diagnosis and their potential application in CRC treatment, highlighting their importance as a promising avenue for further research and clinical translation.

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Section: Inhibit Cancer Cell Proliferation and Promote Apoptosis Of C...mentioning

confidence: 99%

Progress of regulatory RNA in small extracellular vesicles in colorectal cancer

Zhou

et al. 2023

Front. Cell Dev. Biol.

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“…It is well-known that microRNAs and long noncoding RNAs are now critical areas for investigating tumor progression and developing treatment alternatives. They control various events in cancer progression, including immune response, angiogenesis, EMT, and drug resistance. , Therefore, surface packing of miR-497, miR-375-3, miR-34a, miR-138-5p, and miR-126 mimics on sEVs has evolved into a novel anticancer strategy. As expected, they exerted target specific bioactivity and inhibited tumor growth in the corresponding experimental models.…”

Section: Small Evs In Cancer Drug Deliverymentioning

confidence: 99%

Recent Trends in the Use of Small Extracellular Vesicles as Optimal Drug Delivery Vehicles in Oncology

Kumar

Manda

2023

Mol. Pharmaceutics

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Small extracellular vesicles (sEVs) are produced by most cells and play an important role in cell-to-cell communication and maintaining cellular homeostasis. Their ability to transfer biological cargo to target cells makes them a promising tool for cancer drug delivery. Advances in sEV engineering, EV mimetics, and ligand-directed targeting have improved the efficacy of anticancer drug delivery and functionality. EV-based RNA interference and hybrid miRNA transfer have also been extensively used in various preclinical cancer models. Despite these developments, gaps still exist in our understanding of using sEVs to treat solid tumor malignancies effectively. This article provides an overview of the last five years of sEV research and its current status for the efficient and targeted elimination of cancer cells, which could advance cancer research and bring sEV formulations into clinical use.

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“…By blocking the MNK/eIF4E axis, exosome-mediated transportation of miR-7-5p improves the anti-cancer effect of Everolimus in non-small cell lung cancer [ 102 ]. In addition, exosomes carrying miR-34a promote apoptosis and restrict the migration and development of colorectal cancer cells [ 103 ]. Exosomal miR-499 inhibited tumor formation and angiogenesis [ 104 ] in endometrial cancer patients, where miR-499 expression was significantly decreased in cancer tissues compared to surrounding tissues.…”

Section: Therapeutic Targetmentioning

confidence: 99%