2022
DOI: 10.1007/s10565-022-09728-y
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Tumor-derived exosomes orchestrate the microRNA-128-3p/ELF4/CDX2 axis to facilitate the growth and metastasis of gastric cancer via delivery of LINC01091

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Cited by 14 publications
(8 citation statements)
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“…Studies have reported that Hippo-YAP signaling is important for the activation of nuclear transcription factor CDX2 expression in mouse embryos [ 30 , 31 ]. Meanwhile, CDX2 is preferentially expressed in GC [ 32 , 33 ]. Therefore, we further explored the relationship between YAP and CDX2 in GC.…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…Studies have reported that Hippo-YAP signaling is important for the activation of nuclear transcription factor CDX2 expression in mouse embryos [ 30 , 31 ]. Meanwhile, CDX2 is preferentially expressed in GC [ 32 , 33 ]. Therefore, we further explored the relationship between YAP and CDX2 in GC.…”
Section: Resultsmentioning
confidence: 99%
“…Notably, downregulation of YAP results in a decline of CDX2 expression in GC cells [ 43 ]. CDX2 is abundant in GC tissues and cells, which augments the proliferative, migrating, and invasive properties of GC cells [ 32 ]. Altogether, these lines of evidence suggest a novel regulatory pathway of H19/YAP/CDX2 in GC which can serve as a potential target for cancer therapy.…”
Section: Discussionmentioning
confidence: 99%
“…LINC01091 and LINC01359 were also found to be deregulated in the three main subtypes of male infertility, namely asthenozoospermia [ 41 ], teratozoospermia [ 45 ], and oligozoospermia [ 37 ]. LINC01091 also seems to have a role in cancer, as it regulates tumorigenesis and metastasis in gastric cancer [ 99 ], and is also implicated to have a role in prostate cancer [ 100 ]. Similarly, it has been reported that LINC01359 could serve as a potential biomarker for hepatocellular carcinoma [ 101 ].…”
Section: Discussionmentioning
confidence: 99%
“…For instance, ELF4 is highly expressed in human glioblastomas (GBM), promotes GBM cell proliferation and stemness, and influences the survival periods of GBM patients [9]. In gastric cancer, ELF4 is upregulated by LINC01091, which then transcriptionally upregulates the expression of CDX2 to promote the development of GC [10]. In HBV-associated HCC, ELF4 activates telomerase to drive the progression of HCC, and the sphere-forming property of HCC cells is suppressed after ELF4 knockdown [11].…”
Section: Ivyspringmentioning
confidence: 99%