Tumor Detection with 1-Aminocyclopentane and 1-Aminocyclobutane C-11-Carboxylic Acid Using Positron Emission Computerized Tomography

Non-natural amino acids for tumor imaging using positron emission tomography and single photon emission computed tomography

“…In a preliminary study using [ 11 C]ACPC in 33 patients with known breast metastases, ameloblastoma, lymphoma and metastatic adenocarcinoma, and lung, breast and bone cancer, increased uptake was observed in 70% of lesions using a single photon rectilinear scanner [162]. In a more recent study comparing [ 11 C]ACPC with [ 11 C]ACBC in seven human subjects with an islet cell tumor, bronchogenic cancer and lung (breast cancer), bone (breast cancer) and liver (lung cancer) metastasis, increased uptake was observed in lesions in all subjects using a PET scanner [163]. [ 11 C]ACBC has also been studied in human subjects with intracranial tumors.…”

Pilot Evaluation of Anti-1-amino-2-[18F] fluorocyclopentane-1-carboxylic acid (anti-2-[18F] FACPC) PET-CT in Recurrent Prostate Carcinoma

“…cyclotron by Washburn [13]. In two studies using [ 11 C] ACPC in patients with known carcinomas, increased uptake of the radiotracer was observed [14, 15]. …”

Synthesis and biological properties of radiohalogenated α,α‐disubstituted amino acids for PET and SPECT imaging of amino acid transporters (AATs)

“…Goodman and colleagues subsequently reported that [ 11 C]ACBC can also be prepared in high specific activity with a no‐carrier added synthesis . In a series of preliminary studies, [ 11 C]ACBC and [ 11 C]ACPC were observed to show increased uptake in lesions of a variety of tumor types in human subjects using rectilinear and PET scanners . More recently, [ 11 C]ACBC has been studied in human subjects with intracranial tumors and was shown to be more efficacious than [ 18 F]FDG, MR, or CT in detecting recurrent brain tumors …”