Tumor DNA content as a prognostic indicator in squamous cell carcinoma of the oral cavity and tongue base

Bueno, Pilar Rubio; Gı́as, Luis Naval; Delgado, Rosa; Cebollada, Javier Domingo; González, Francisco Díaz

doi:10.1002/(sici)1097-0347(199805)20:3<232::aid-hed8>3.0.co;2-1

Cited by 35 publications

(21 citation statements)

References 33 publications

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“…16 based on their research, have found that the malignant potential is more in premalignant lesions with higher DNA content than lesions with normal DNA content irrespective of any histopathological grading of tumor. Therefore, cancers with higher DNA content predict the aggressiveness of the tumor 17 and such cancers have greater probability for spread through perineural invasion and lymph node metastasis. Loss of heterozygosity (LOH) is defined as loss of genomic material in one of the chromosomal pair.…”

Section: Molecular Markers For Oral Cancerssupporting

confidence: 76%

Role of Salivary Biomarkers for Early Detection of Oral Squamous Cell Carcinoma

2017

International Journal of Advanced and Integrated Medical Sciences

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Introduction Oral cancer is a potentially fatal disease, which constitutes an important portion of tumors of the head and neck region. Among head and neck cancers, oral squamous cell carcinomas (OSCCs) constitute 90% of total cancers. Regardless of the fact that the oral cavity is easily accessible to the accumulation of carcinogens, most oral cancers are typically detected at an advanced stage leading to lower survival rate among subjects. Abnormal cellular products elucidated from malignant cells can be detected and measured in various body fluids including saliva, which constitute tumor markers. Saliva, an aqueous biological fluid, is in direct contact with the oral cancer lesion. Hence, the saliva in any stage of oral cancer constitutes abnormal deoxyribonucleic acid (DNA), acid (RNA), and protein molecules. Saliva, being a noninvasive diagnostic aid, can be an alternative to serum for early detection, status of chemotherapy regime, and also patient prognosis. This article aims at providing a brief overview of various salivary biomarkers and their implications in oral cancer. How to cite this article Gupta P. Role of Salivary Biomarkers for Early Detection of Oral Squamous Cell Carcinoma. Int J Adv Integ Med Sci 2017;2(3):155-160.

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Section: Molecular Markers For Oral Cancerssupporting

confidence: 76%

Role of Salivary Biomarkers for Early Detection of Oral Squamous Cell Carcinoma

2017

International Journal of Advanced and Integrated Medical Sciences

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“…Several studies have shown that aneuploid tumours are more aggressive than diploid tumours in head and neck cancers (Hogmo et al, 1994;Rubio Bueno et al, 1998). Proliferative activity, as determined by expression levels of the Ki-67 nuclear antigen, has been linked to prognosis and treatment prediction with varying results in oral cancer, with few studies performed exclusively in OTSCC (Xie et al, 1999;Pich et al, 2004;Lothaire et al, 2006;Kim et al, 2007).…”

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confidence: 63%

Ki-67 expression predicts locoregional recurrence in stage I oral tongue carcinoma

et al. 2008

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Oral tongue squamous cell carcinoma (OTSCC) is an aggressive cancer associated with poor prognosis. Methods for determining the aggressiveness of OTSCC from analysis of the primary tumour specimen are thus highly desirable. We investigated whether genomic instability and proliferative activity (by means of Ki-67 activity) could be of clinical use for prediction of locoregional recurrence in 76 pretreatment OTSCC paraffin samples (stage I, n ¼ 22; stage II, n ¼ 33; stage III, n ¼ 8; stage IV, n ¼ 13). Eleven surgical tumour specimens were also analysed for remnants of proliferative activity after preoperative radiotherapy. Ninety-seven percent of cases (n ¼ 72) were characterised as being aneuploid as measured by means of image cytometry. Preoperative radiotherapy (50 -68 Gy) resulted in significant reduction of proliferative activity in all patients for which post-treatment biopsies were available (P-value ¼ 0.001). Proliferative activity was not associated with response to radiation in stage II patients. However, we report a significant correlation between high proliferation rates and locoregional recurrences in stage I OTSCC patients (P-value ¼ 0.028). High-proliferative activity is thus related to an elevated risk of recurrence after surgery alone. We therefore conclude that Ki-67 expression level is a potentially useful clinical marker for predicting recurrence in surgically treated stage I OTSCC.

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“…It appears to be an independent prognostic factor for relapse and death; it was found useful also as a valuable differential diagnosis marker for nondysplastic oral white patches or as predictor of occult nodal metastasis. [70][71][72] However, debate has been maintained over this issue owing to the reported intratumoral heterogeneity of DNA ploidy, with some authors defending a homogeneous distribution of ploidy in the tumor maintained even in the metastasis (although ploidy has not been correlated with prognosis) 73 and others reporting heterogeneity and thus limited application to predict prognosis. 74 The study of DNA content of cells in the tumor invasive front, considered important to measure tumor aggressiveness (and therefore predict outcome), suggested an influence on disease-specific survival, especially if in conjunction with clinical findings.…”

Section: Review Of the Literature Patient-related Factorsmentioning

confidence: 99%