Pharmaceutical Sciences Encyclopedia 2015
DOI: 10.1002/9780470571224.pse551
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Tumor Effect‐Site Pharmacokinetics: Mechanisms and Impact on Efficacy

Abstract: Biologics, particularly monoclonal antibodies, form a rapidly growing field of cancer therapeutics. These molecules have exquisite specificity for their targets, thereby reducing off‐target effects. However, there are inherent challenges in managing the pharmacokinetics of biologics. In this chapter, focus on how mechanisms of distribution and efficacy play out at the site of action for cancer biologics: the tumor. The chapter first describes the distribution of antibodies and other macromolecules in tumors co… Show more

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