Abstract:The development of an effective antitumor response relies on the synergistic actions of various immune cells that recognize tumor cells via distinct receptors. Tumors, however, often manipulate receptor–ligand interactions to evade recognition by the immune system. Recently, we highlighted the role of neolacto‐series glycosphingolipids (nsGSLs), produced by the enzyme β1,3‐N‐acetylglucosaminyltransferase 5 (B3GNT5), in tumor immune escape. We previously demonstrated that loss of signal peptide peptidase like 3… Show more
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