Tumor extent of slowly progressive oligodendroglioma determined by18F-fluorophenylalanine positron emission tomography

Mineura, Katsuyoshi; Shioya, Hitoshi; Kowada, Masayoshi; Uemura, Kazunori

doi:10.1016/s0720-048x(96)01130-8

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2008

2024

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“…L-4-Fluorophenylalanine (FPhe), as an important unnatural amino acid, is an inhibitor of human hydroxylase and is an antitumor agent [3,4]. 19 FPhe can also be used as an isotope tracer to monitor the growth of tumors [5]. Meanwhile, FPhe with the strong electron-attracting fluoro group is nearly the isostere of phenylalanine and extensively participates in polypeptide synthesis [6].…”

Section: Introductionmentioning

confidence: 99%

Recombinant aspartate aminotransferase-catalyzed synthesis of L-4-fluorophenylalanine

Chen

Jia

Chen

et al. 2008

Front. Chem. Eng. China

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L-4-Fluorophenylalanine (FPhe) was prepared from 4-fluorophenylpyruvate (FPPA) catalyzed by aspartate aminotransferase (Asp-AT) of the recombinant E. coli BL21-pET/aspC. After 12 h enzymatic reaction, the FPPA conversion was over 90% and the yield of FPhe could be above 85% under the following optimal conditions: 37uC, pH value range of 5.0-8.0, 5.5 mass ratio of cell to FPPA, 0.6% (w/v) of Tween 80, 7.08 g/L FPPA, and 1.6 of molar ratio of L-Asp to FPPA.

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Section: Introductionmentioning

confidence: 99%