Tumor hypoxia and role of hypoxia-inducible factor in oral cancer

Singh, Pooja; Rajput, Monika; Pandey, Manoj

doi:10.1186/s12957-023-03284-3

Cited by 4 publications

References 107 publications

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T lymphocyte and neutrophil/lymphocyte ratio in patients with radiation-induced oral mucositis after intensity-modulated radiation therapy for head and neck cancer: A retrospective single-center study

Qi,

Yin,

Jia

et al. 2024

Medicine

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To investigate T lymphocyte, neutrophil/lymphocyte ratio (NLR) and their impact on patients with radiation-induced oral mucositis (RIOM) after intensity-modulated radiotherapy for head and neck cancer. The clinical data of 148 patients diagnosed with head and neck cancer from January 2016 to January 2019 were retrospectively analyzed. Patients were divided into RIOM group (n = 42 cases) and non-RIOM group (n = 106 cases), based on whether they developed RIOM after intensity-modulated radiation therapy. The T lymphocyte and NLR of the 2 groups were analyzed before and after treatment; The correlation between T lymphocyte and NLR in RIOM group was analyzed. We used RTOG grading system to evaluate and scale the RIOM. The relationship between the grade of RIOM, T lymphocyte and NLR in RIOM group was analyzed. After treatment, the proportion of CD3 +, CD4 +, and CD8 + T lymphocytes in the 2 groups after treatment were decreased, and the RIOM group was significantly lower than non-RIOM group, P < .05. NLR in RIOM group was significantly higher than that in non-RIOM group, P < .05. The data of overall survival showed no significant differences between 2 groups (HR = 0.82, 95% CI: 0.43–1.59). Compared with RIOM group, patients in non-RIOM group showed a longer progress-free survival (HR = 0.57, 95% CI: 0.33–0.99). In RIOM group, NLR was negatively correlated with CD3 + (r = −0.433, P = .004), CD4 + (r = −0.644, P < .001) and CD8 + T cells (r = −0.665, P < .001). RIOM was positively correlated with NLR (R = 0.621, P < .001), negatively correlated with CD4 + T cell ratio (r = −0.449, P = .003) and CD8 + T cell ratio (r = −0.307, P = .048), but RIOM did not correlate with CD3 + T cell ratio (r = −0.225, P = .152). For patients with RIOM after intensity-modulated radiotherapy for head and neck cancer, T lymphocyte showed a downward trend, and NLR showed an upward trend. In addition, T lymphocyte and NLR are closely related to the RIOM, indicating that clinicians should be aware of the importance of T lymphocyte and NLR on patients received radiotherapy.

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T lymphocyte and neutrophil/lymphocyte ratio in patients with radiation-induced oral mucositis after intensity-modulated radiation therapy for head and neck cancer: A retrospective single-center study

Qi,

Yin,

Jia

et al. 2024

Medicine

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Tumor Microenvironment In Head And Neck Cancer: Insights From Spheroids

Rao,

Das,

Ghodeswar

et al. 2024

Preprint

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The study of head and neck cancer (HNC) has been significantly enhanced by the development of 3D spheroid models, which closely replicate the in vivo tumor microenvironment (TME) by preserving cellular heterogeneity, hypoxic regions, and tumor-specific cell interactions. Traditional 2D models lack the capacity to capture these critical characteristics, which are essential for understanding tumor biology and therapeutic responses. This review summarizes recent advancements in HNC spheroid research, with a focus on their applications in drug testing, TME simulation, and therapeutic development. We discuss the role of spheroids in modeling key aspects such as drug resistance, hypoxia, cancer stem cell behavior, and epithelial-mesenchymal transition (EMT). Despite challenges, including variability and scalability limitations, 3D models hold significant promise for advancing precision medicine in HNC. We also explore the use of these models in evaluating therapeutic strategies, including chemotherapy, molecular-targeted therapies, and immunotherapy. Furthermore, we conduct a bibliometric analysis to assess research trends and identify emerging topics within the field of HNSCC and 3D tumor modeling. The ability of 3D spheroid models to predict patient-specific responses to treatment is highlighted, underscoring their potential for advancing personalized medicine. By examining key cellular processes that drive tumor progression and therapy resistance, we evaluate how effectively these models replicate tumor biology and speculate on future advancements that could further enhance their relevance in cancer research and treatme

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Therapeutic Effects of Taurine and Histidine Supplementation in Retinal Diseases

Lee,

Smith

2024

Life

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Amino acids are basic building blocks of structural proteins and enzymes. They also act as signaling molecules and as fuel. They are characterized as essential if sufficient quantities must be supplied exogenously or as non-essential if they can be endogenously synthesized. Appropriate intake of amino acids not only prevents the development of metabolic diseases but also can reduce the progression of some disease states. Amino acids are strongly associated with retinal metabolism in physiology and pathology. Nonetheless, there is a lack of robust clinical studies supporting the benefits of amino acid supplementation in retinopathy. In this review, we summarize preclinical evidence concerning the potential of supplementing the amino acids taurine and histidine to provide protection against diabetic retinopathy, glaucoma, and age-related macular degeneration. We suggest further directions for studying amino acid-based therapeutic interventions for eye diseases.

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Tumor hypoxia and role of hypoxia-inducible factor in oral cancer

Cited by 4 publications

References 107 publications

T lymphocyte and neutrophil/lymphocyte ratio in patients with radiation-induced oral mucositis after intensity-modulated radiation therapy for head and neck cancer: A retrospective single-center study

T lymphocyte and neutrophil/lymphocyte ratio in patients with radiation-induced oral mucositis after intensity-modulated radiation therapy for head and neck cancer: A retrospective single-center study

Tumor Microenvironment In Head And Neck Cancer: Insights From Spheroids

Therapeutic Effects of Taurine and Histidine Supplementation in Retinal Diseases

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