Tumor immunity against adult T‐cell leukemia

Kannagi, Mari; Harashima, Nanae; Kurihara, Ken; Ohashi, Takashi; Utsunomiya, Atae; Tanosaki, Ryuji; Masuda, Masato; Tomonaga, Masao; Okamura, Jun

doi:10.1111/j.1349-7006.2005.00050.x

Cited by 46 publications

(45 citation statements)

References 60 publications

(66 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The proviral load of Tax [11][12][13][14][15][16][17][18][19] tetramer-positive AC was significantly lower than that of Tax [11][12][13][14][15][16][17][18][19] tetramer-negative AC (mean Ϯ SE, 38.1 Ϯ 13.8 vs 74.8 Ϯ 8.0; p ϭ 0.043; Table IV). These findings are consistent with Bangham's report (47) and suggest that Tax [11][12][13][14][15][16][17][18][19] CTL works as a strong down-regulator of the proviral load. In contrast, with regard to Tax 301-309 tetramer, there was no significant difference between the proviral load of Tax 301-309 tetramer-positive AC and negative AC (mean Ϯ SE, 72.4 Ϯ 9.4 vs 53.5 Ϯ 11.6; Table IV).…”

Section: Htlv-1 Proviral Load In Ac and Atl Patientsmentioning

confidence: 99%

“…In contrast, with regard to Tax 301-309 tetramer, there was no significant difference between the proviral load of Tax 301-309 tetramer-positive AC and negative AC (mean Ϯ SE, 72.4 Ϯ 9.4 vs 53.5 Ϯ 11.6; Table IV). The reason why the proviral load of Tax 301-309 tetramer-positive AC was lower than that of negative AC can be explained by the negative group containing many Tax [11][12][13][14][15][16][17][18][19] tetramer-positive AC (7 of 13). Therefore, we omitted HLA-A*02-positive (including HLA-A*0201 and HLA-A*0206) subjects in analysis of Tax 301-309 tetramer.…”

Section: Htlv-1 Proviral Load In Ac and Atl Patientsmentioning

confidence: 99%

“…With regard to Tax 11-19 -specific tetramer binding cells in individual subjects with HLA-A*0201, the frequency of percentage of CD8 ϩ T cells binding Tax [11][12][13][14][15][16][17][18][19] /HLA-A*0201 tetramer in Table II. b Epitopes detected by HTLV-1/HLA tetramers/number of tetramers tested.…”

Section: Frequency Of Anti-htlv-1 Cd8 ϩ T Cells In Pbmc Of Ac and Atlmentioning

confidence: 99%

“…In contrast, ATL recognized only Tax [11][12][13][14][15][16][17][18][19] with HLA-A*0201 and Tax 301-309 with HLA-A*2402 at frequencies of 30 and 55%, respectively. Among the individual HTLV-1/ HLA tetramers, two (Tax [11][12][13][14][15][16][17][18][19] , p ϭ 0.0042; and Tax 301-309 , p ϭ 0.0031; Table II) were significantly more frequent in AC than ATL. Among AC, 24% of Tax epitopes were positive, whereas significantly fewer epitopes were positive among ATL (9%, p ϭ 0.0004; Table II).…”

Section: Frequency Of Anti-htlv-1 Cd8 ϩ T Cells In Pbmc Of Ac and Atlmentioning

confidence: 99%

“…HTLV-1-specific CTL plays an important role in suppressing proliferation of HTLV-1-infected or -transformed T cells in vitro (9 -12) and thus may prevent development of ATL (13,14). Because ATL develops in ϳ2% of people infected with HTLV-1 after a long latent period (15), it is possible that CTL fails in only a fraction of HTLV-1 carriers with a specific immunogenetic background (16 -18).…”

mentioning

confidence: 99%

See 4 more Smart Citations

Reduced Frequency, Diversity, and Function of Human T Cell Leukemia Virus Type 1-Specific CD8+ T Cell in Adult T Cell Leukemia Patients

Kozako

Arima

Toji

et al. 2006

The Journal of Immunology

View full text Add to dashboard Cite

Human T cell lymphotropic virus type 1 (HTLV-1)-specific CTL are thought to be immune effectors that reduce the risk of adult T cell leukemia (ATL). However, in vivo conditions of anti-HTLV-1 CTL before and after ATL development have yet to be determined. To characterize anti-HTLV-1 CTL in asymptomatic HTLV-1 carriers (AC) and ATL patients, we analyzed the frequency and diversity of HTLV-1-specific CD8+ T cells in PBMC of 35 AC and 32 ATL patients using 16 distinct epitopes of HTLV-1 Tax or Env/HLA tetramers along with intracellular cytolytic effector molecules (IFN-γ, perforin, and granzyme B). Overall frequency of subjects possessing Tax-specific CD8+ T cells was significantly lower in ATL than AC (53 vs 90%; p = 0.001), whereas the difference in Env-specific CD8+ T cells was not statistically significant. AC possessed Tax11–19/HLA-A*0201-specific tetramer+ cells by 90% and Tax301–309/HLA-A*2402-specific tetramer+ cells by 92%. Some AC recognized more than one epitope. In contrast, ATL recognized only Tax11–19 with HLA-A*0201 and Tax301–309 with HLA-A*2402 at frequencies of 30 and 55%. There were also significant differences in percentage of cells binding Tax11–19/HLA-A*0201 and Tax301–309/HLA-A*2402 tetramers between AC and ATL. Anti-HTLV-1 Tax CD8+ T cells in AC and ATL produced IFN-γ in response to Tax. In contrast, perforin and granzyme B expression in anti-HTLV-1 CD8+ T cells of ATL was significant lower than that of AC. Frequency of Tax-specific CD8+ T cells in AC was related to proviral load in HLA-A*0201. These results suggest that decreased frequency, diversity, and function of anti-HTLV-1 Tax CD8+ T cell clones may be one of the risks of ATL development.

show abstract

Section: Htlv-1 Proviral Load In Ac and Atl Patientsmentioning

confidence: 99%

Section: Htlv-1 Proviral Load In Ac and Atl Patientsmentioning

confidence: 99%

Section: Frequency Of Anti-htlv-1 Cd8 ϩ T Cells In Pbmc Of Ac and Atlmentioning

confidence: 99%

Section: Frequency Of Anti-htlv-1 Cd8 ϩ T Cells In Pbmc Of Ac and Atlmentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

Reduced Frequency, Diversity, and Function of Human T Cell Leukemia Virus Type 1-Specific CD8+ T Cell in Adult T Cell Leukemia Patients

Kozako

Arima

Toji

et al. 2006

The Journal of Immunology

View full text Add to dashboard Cite

show abstract

Retroviruses

2010

Infectious Causes of Cancer

View full text Add to dashboard Cite

A plasma diagnostic model of human T‐cell leukemia virus‐1 associated myelopathy

Ishihara

Araya

Sato

et al. 2015

Ann Clin Transl Neurol

View full text Add to dashboard Cite

ObjectiveHuman T-cell leukemia virus-1 (HTLV-1) associated myelopathy/tropic spastic paraparesis (HAM/TSP) is induced by chronic inflammation in spinal cord due to HTLV-1 infection. Cerebrospinal fluid (CSF) neopterin or proviral load are clinically measured as disease grading biomarkers, however, they are not exactly specific to HAM/TSP. Therefore, we aimed to identify HAM/TSP-specific biomarker molecules and establish a novel less-invasive plasma diagnostic model for HAM/TSP.MethodsProteome-wide quantitative profiling of CSFs from six asymptomatic HTLV-1 carriers (AC) and 51 HAM/TSP patients was performed. Fourteen severity grade biomarker proteins were further examined plasma enzyme-linked immunosorbent assay (ELISA) assays (n = 71). Finally, we constructed three-factor logistic regression model and evaluated the diagnostic power using 105 plasma samples.ResultsQuantitative analysis for 1871 nonredundant CSF proteins identified from 57 individuals defined 14 CSF proteins showing significant correlation with Osame's motor disability score (OMDS). Subsequent ELISA experiments using 71 plasma specimens confirmed secreted protein acidic and rich in cysteine (SPARC) and vascular cell adhesion molecule-1 (VCAM-1) demonstrated the same correlations in plasma (R = −0.373 and R = 0.431, respectively). In this training set, we constructed a HAM/TSP diagnostic model using SPARC, VCAM1, and viral load. Sensitivity and specificity to diagnose HAM/TSP patients from AC (AC vs. OMDS 1–11) were 85.3% and 81.1%, respectively. Importantly, this model could be also useful for determination of therapeutic intervention point (OMDS 1–3 + AC vs. OMDS 4–11), exhibiting 80.0% sensitivity and 82.9% specificity.InterpretationWe propose a novel less-invasive diagnostic model for early detection and clinical stratification of HAM/TSP.

show abstract

Tumor immunity against adult T‐cell leukemia

Abstract: Human T-cell leukemia virus type-I (HTLV-I) causes adult T-cell

Cited by 46 publications

References 60 publications

Reduced Frequency, Diversity, and Function of Human T Cell Leukemia Virus Type 1-Specific CD8+ T Cell in Adult T Cell Leukemia Patients

Reduced Frequency, Diversity, and Function of Human T Cell Leukemia Virus Type 1-Specific CD8+ T Cell in Adult T Cell Leukemia Patients

Retroviruses

A plasma diagnostic model of human T‐cell leukemia virus‐1 associated myelopathy

Contact Info

Product

Resources

About