Tumor-induced osteomalacia: a case report

Aligail, Khalid; Dave, Joel A.; Ross, Ian Louis

doi:10.1186/s13256-021-03220-7

Cited by 3 publications

(2 citation statements)

References 31 publications

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“…They should be managed wisely. Other hormonal causes of ATF are tumor-induced osteomalacia (FGF-23) and hyperparathyroidism [ 59 , 60 ]. ATF fractures with fracture cascades related to hyperparathyroidism (as in Case 3) were also reported in France and Brazil [ 61 , 62 ].…”

Section: Discussionmentioning

confidence: 99%

Atraumatic Fractures in Multi-Morbid Older Adults: A Series of Five Cases and Review of Literature

Rohaiem,

Khan,

Al-Julaih

et al. 2023

Cureus

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Atraumatic fractures (ATFs) are a fragility fracture subtype with occasional medicolegal issues. ATFs are defined as fractures because of a “low-energy mechanism that is usually considered incapable of producing a fracture.” They are an underreported disorder, with epidemiological variations. ATF phenomena were previously reported not only in older adults, but also in children, young adults, older adults, and animals. This study is a short retrospective case series exploring atraumatic fractures in a tertiary care university hospital. Over a period of two years, a total of seven ATF cases were identified. However, only five fulfilled the inclusion criteria. Local causes of pathologic fractures (e.g., metastasis) and elder abuse or neglect were excluded. Comparison of the cases’ clinical profile, fracture profile, and management was done. All five cases were frail females with significant osteotoxic burdens from medications and multi-morbidities. ATF presentations included typical (as pain) and atypical (as painless, loud crack, and sudden giveaway) symptomatology. One ATF had a coincident unexplained aseptic fever. Three cases had more than one fracture (fracture cascade), confirmed and followed up by x-rays. All the cases were managed conservatively except for one case that underwent hip hemiarthroplasty. Plans of care included managing the osteotoxic multi-morbidities burden, focusing on the whole body, not only on the fracture or bone. The study provided insights about challenges in presentations of ATF (as the bone fracture acute phase reaction: osteogenic aseptic fever). Risk factors are classically assumed to be osteoporosis, but it is usually systemic and multifactorial. A high risk of fracture warning sign could help decrease ATF occurrence or fracture cascades. Four ATF categories were detected to help healthcare systems identify high-risk patients and raise awareness among medical staff, families, and caregivers. Future studies of the at-risk groups are needed to understand ATF knowledge gaps, challenges, and the best treatments.

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Section: Discussionmentioning

confidence: 99%

Atraumatic Fractures in Multi-Morbid Older Adults: A Series of Five Cases and Review of Literature

Rohaiem,

Khan,

Al-Julaih

et al. 2023

Cureus

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“…5 TIO is characterized by hypophosphatemia due to high FGF-23 levels what leads to decreased renal phosphate reabsorption and low or normal vitamin D level. 6 Tumors producing FGF-23 can be located anywhere in the body in both bones and soft tissue what makes them hard to locate. 7 The symptoms of this condition are generalized weakness, diffused bone pain, frequent bone fractures, bone deformities, what causes functional impairment.…”

Section: Introductionmentioning

confidence: 99%

Challenging diagnosis of a rare disease: hypophosphatemic osteomalacia – case report and literature review

Nowak,

Partyka,

Pach

et al. 2024

J Educ Health Sport

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Hypophosphatemic osteomalacia is a rare condition caused by different causes, all resulting in disturbances of calcium-phosphate management. One of the most common causes among adults is tumor-induced osteomalacia, which is characterized by increased secretion of fibroblast growth factor-23. Its symptoms are vague, tests necessary for diagnosis are not commonly used by clinicians and some of them are only available in highly specialized centers. Due to these reasons, patients often are misdiagnosed for more common conditions and are left without proper treatment for many years. We present a case of a patient suffering from multiple fractures, diffuse bone pain, and muscle weakness, who was previously misdiagnosed for osteoporosis, primary and secondary hyperparathyroidism. We discuss the pathophysiology of tumor-induced osteomalacia, diagnostic path, differential diagnosis, available forms of treatment and possible complications.

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A case report of Tumor-Induced Osteomalacia (TIO) caused by central giant cell granuloma

Rad,

Bahrami,

Houshyar

et al. 2024

Bone Reports

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Tumor-induced osteomalacia: a case report

Cited by 3 publications

References 31 publications

Atraumatic Fractures in Multi-Morbid Older Adults: A Series of Five Cases and Review of Literature

Atraumatic Fractures in Multi-Morbid Older Adults: A Series of Five Cases and Review of Literature

Challenging diagnosis of a rare disease: hypophosphatemic osteomalacia – case report and literature review

A case report of Tumor-Induced Osteomalacia (TIO) caused by central giant cell granuloma

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