Tumor‐induced osteomalacia originating from the temporal bone: A case report

Kobayashi, Kenya; Nakao, Kazunari; Kawai, Kensuke; Ito, Ken; Hukumoto, Seiji; Asakage, Takahiro; Oota, Satoshi; Motoi, Ryo

doi:10.1002/hed.21355

Cited by 13 publications

(10 citation statements)

References 12 publications

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“…To our knowledge, most publications about surgical excision of phosphaturic mesenchymal tumors have been case reports [17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32] , and very few were case series 2,33,34 . Phosphaturic mesenchymal tumors seem to be commonly located in long bones, but we are not aware of any studies comparing the results of curettage and segmental resection with a minimum one-year follow-up.…”

Section: Discussionmentioning

confidence: 99%

Surgical Treatments of Tumor-Induced Osteomalacia Lesions in Long Bones

Wang

Zhong

Liu

et al. 2015

The Journal of Bone and Joint Surgery

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Section: Discussionmentioning

confidence: 99%

Surgical Treatments of Tumor-Induced Osteomalacia Lesions in Long Bones

Wang

Zhong

Liu

et al. 2015

The Journal of Bone and Joint Surgery

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“…[1] Occurrence in intracranial and craniovertebral region is very rare, and only a few cases have been reported. [23456] We hereby report two rare cases of PMT, the first case being intracranial involving the temporal bone and the second a skull base tumor originating from the occipital–temporal bone.…”

Section: Introductionmentioning

confidence: 99%

Phosphaturic mesenchymal tumors involving skull bones: Report of two rare cases

2019

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Phosphaturic mesenchymal tumor (PMT) is a rare tumor causing oncogenic osteomalacia (OO). Most such tumors occur in soft tissue and bones of extremities and appendicular skeleton. Intracranial location and involvement of temporal–occipital bone is extremely rare. We report two unusual cases: The first was intracranial, involving the temporal bone, while the other was a skull base tumor arising from the occipital–temporal bone. Both of them presented with paraneoplastic syndrome of OO, resembled a meningioma radiologically, and underwent gross total resection of tumor. Histologically, both of them were diagnosed as PMT, mixed connective tissue variant.

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“…Fibroblast growth factor‐23 (FGF‐23), a phosphatonin, has been identified as a major pathophysiological factor responsible for phosphate wasting in TIO 3, 4. Until this time, there were only 269 cases described in the world's literature over 61 years 5–98…”

Section: Introductionmentioning

confidence: 99%

Tumor-induced osteomalacia: An important cause of adult-onset hypophosphatemic osteomalacia in China: Report of 39 cases and review of the literature

Jiang

Xia

Xing

et al. 2012

Journal of Bone and Mineral Research

196

190

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Tumor-induced osteomalacia (TIO) is an acquired form of hypophosphatemia. Tumor resection leads to cure. We investigated the clinical characteristics of TIO, diagnostic methods, and course after tumor resection in Beijing, China, and compared them with 269 previous published reports of TIO. A total of 94 patients with adult-onset hypophosphatemic osteomalacia were seen over a 6-year period (January, 2004 to May, 2010 in Peking Union Medical College Hospital. After physical examination (PE), all patients underwent technetium-99m octreotide scintigraphy ( 99 Tc m -OCT). Tumors were removed after localization. The results demonstrated that 46 of 94 hypophosphatemic osteomalacia patients had high uptake in 99 Tc m -OCT imaging. Forty of them underwent tumor resection with the TIO diagnosis established in 37 patients. In 2 patients, the tumor was discovered on PE but not by 99 Tc m -OCT. The gender distribution was equal (M/F ¼ 19/20). Average age was 42 AE 14 years. In 35 patients (90%), the serum phosphorus concentration returned to normal in 5.5 AE 3.0 days after tumor resection. Most of the tumors (85%) were classified as phosphaturic mesenchymal tumor (PMT) or mixed connective tissue variant (PMTMCT). Recurrence of disease was suggested in 3 patients (9%). When combined with the 269 cases reported in the literature, the mean age and sex distribution were similar. The tumors were of bone (40%) and soft tissue (55%) origins, with 42% of the tumors being found in the lower extremities. In summary, TIO is an important cause of adult-onset hypophosphatemia in China. 99 Tc m -OCT imaging successfully localized the tumor in the overwhelming majority of patients. Successful removal of tumors leads to cure in most cases, but recurrence should be sought by long-term follow-up. ß

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Tumor‐induced osteomalacia originating from the temporal bone: A case report

Abstract: We discuss the clinical features and treatment options for this rare disease.

Cited by 13 publications

References 12 publications

Surgical Treatments of Tumor-Induced Osteomalacia Lesions in Long Bones

Surgical Treatments of Tumor-Induced Osteomalacia Lesions in Long Bones

Phosphaturic mesenchymal tumors involving skull bones: Report of two rare cases

Tumor-induced osteomalacia: An important cause of adult-onset hypophosphatemic osteomalacia in China: Report of 39 cases and review of the literature

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