2011
DOI: 10.1200/jco.2010.30.5037
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Tumor-Infiltrating CD8+ Lymphocytes Predict Clinical Outcome in Breast Cancer

Abstract: Breast carcinomas are often infiltrated by inflammatory cells, particularly macrophages and T lymphocytes, but the significance of these cells remains unclear. One possible role of these inflammatory cells is that they represent a cell-mediated immune response against the carcinoma. CD8(+) lymphocytes are a known crucial component of cell-mediated immunity. The purpose of this study was to explore the prognostic value of tumor-infiltrating CD8(+) cytotoxic lymphocytes in breast cancer. Tumor-infiltrating CD8(+… Show more

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Cited by 1,292 publications
(1,071 citation statements)
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“…In contrast, other studies have also suggested that the presence of tumor-infiltrating lymphocytes (TILs) is an important biomarker for predicting responses to PD-L1 blockade therapy (Tumeh et al, 2014). Interestingly, the presence of TILs has been previously shown to correlate with better patient outcomes during various antitumor therapies in multitude of cancers (Galon et al, 2006;Hwang et al, 2012;Mahmoud et al, 2011). However, it is commonly known that the tumor microenvironment often inhibits activated T cells from entering tumor tissues or prevents effective T cell priming for tumor control through various pathways (Gajewski et al, 2013).…”
Section: Introductionmentioning
confidence: 99%
“…In contrast, other studies have also suggested that the presence of tumor-infiltrating lymphocytes (TILs) is an important biomarker for predicting responses to PD-L1 blockade therapy (Tumeh et al, 2014). Interestingly, the presence of TILs has been previously shown to correlate with better patient outcomes during various antitumor therapies in multitude of cancers (Galon et al, 2006;Hwang et al, 2012;Mahmoud et al, 2011). However, it is commonly known that the tumor microenvironment often inhibits activated T cells from entering tumor tissues or prevents effective T cell priming for tumor control through various pathways (Gajewski et al, 2013).…”
Section: Introductionmentioning
confidence: 99%
“…Its transitory presence in the vicinity of some types of developing cancers, therefore, more likely represents a detoxifying reaction to carcinogenic chemicals or a response to mediators released by chemical irritation of the tissues. On the other hand, CD8(+) T cells are a known active component of cell mediated immunity and a recent histopathological study of 1,334 breast cancer patients [60] has provided some support for a link between better survival and the total lymphocyte count in the tumor and in the surrounding tissues. Higher peri-tumoral B lymphocyte counts were also associated with better prognosis, but the numbers cited were not impressively high (12 cells per field) and the intra-tumoral content was found to be unrelated [61].…”
Section: Inflammation and Cancermentioning
confidence: 99%
“…We [20][21][22][23] and others [15][16][17]19 have shown the prognostic significance of the tumor immune microenvironment in solid malignancies. To the best of our knowledge, there have been no published studies on the association between tumor-infiltrating immune cells and elderly patients in either NSCLC or other solid malignancies.…”
Section: Discussionmentioning
confidence: 90%
“…Published studies have indicated differences in number of tumor-infiltrating immune cells among broad age groups in some solid malignancies. 19,[24][25][26][27] However, these studies were not designed with the explicit purpose of evaluating immune cell infiltration with a specific focus on older patients.…”
Section: Discussionmentioning
confidence: 99%
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