Tumor infiltrating lymphocytes and macrophages have a potential dual role in lung cancer by supporting both host-defense and tumor progression

Kataki, Agapi; Scheid, P.; Piet, Maud; Marie, Béatrice; Martinet, Nadine; Martinet, Yves; Vignaud, Jean-Michel

doi:10.1067/mlc.2002.128317

Cited by 159 publications

(139 citation statements)

References 33 publications

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“…A number of studies have shown that macrophages congregate in large numbers in the hypoxic areas of many solid tumours, which may be due to the influence of hypoxia on the chemoattractant signalling cascade in the tumour microenvironment ( (Negus et al, 1997;Ueno et al, 2000, Grimshaw andBalkwill 2001). Macrophages have the ability to both positively and negatively regulate tumour growth (Mantovani et al, 1992); tumour cell cytostasis may be induced, but in contrast tumour cell survival may be promoted by macrophage activation and release of angiogenic and mitogenic cytokines in the tumour microenvironment, such as VEGF (Barbera-Guillem et al, 2002), pro-inflammatory cytokines and enzymes (Kataki et al, 2002;Blot et al, 2003). A recent in vivo study by Wyckoff et al demonstrated a synergistic relationship between breast tumour cells and macrophages in cell migration and suggested a role for tumour associated macrophages in metastasis (Wyckoff et al, 2004).…”

Section: Discussionmentioning

confidence: 99%

Macrophages promote angiogenesis in human breast tumour spheroids in vivo

et al. 2005

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An in vivo model has been established to study the role of macrophages in the initiation of angiogenesis by human breast tumour spheroids in vivo. The extent of the angiogenic response induced by T47D spheroids implanted into the dorsal skinfold chamber in nude mice was measured in vivo and compared to that induced by spheroids infiltrated with human macrophages prior to implantation. Our results indicate that the presence of macrophages in spheroids resulted in at least a three-fold upregulation in the release of vascular endothelial growth factor (VEGF) in vitro when compared with spheroids composed only of tumour cells. The angiogenic response measured around the spheroids, 3 days after in vivo implantation, was significantly greater in the spheroids infiltrated with macrophages. The number of vessels increased (macrophages vs no macrophages 3471.9 vs 2672.5, Po0.01), were shorter in length (macrophages vs no macrophages 11674.92 vs 13676.52, Po0.008) with an increased number of junctions (macrophages vs no macrophages 1470.93 vs 1171.25, Po0.025) all parameters indicative of new vessel formation. This is the first study to demonstrate a role for macrophages in the initiation of tumour angiogenesis in vivo.

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Section: Discussionmentioning

confidence: 99%

Macrophages promote angiogenesis in human breast tumour spheroids in vivo

et al. 2005

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“…However, not only mast cells are capable of excreting MMPs and other pro-angiogenic factors, also tumor associated macrophages (TAMs), neutrophils and activated T lymphocytes can contribute to angiogenesis by releasing MMPs and angiogenic factors [127][128][129][130]. In a number of cancers, inflammatory cell infiltration correlated with the degree of tumor angiogenesis [131][132][133][134]. The role of inflammatory cell derived MMPs is largely the same compared to tumor cell derived MMPs.…”

Section: The Role Of Mmps In Tumor Angiogenesis and Tumor Growthmentioning

confidence: 99%

The possible role of matrix metalloproteinase (MMP)-2 and MMP-9 in cancer, e.g. acute leukemia

Klein

Vellenga

Fraaije

et al. 2004

Critical Reviews in Oncology/Hematology

312

170

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“…Thus, a comprehensive analysis of the population/ composition of stromal cells and a better understanding of their impact on the process of carcinogenesis may eventually lead to improved anticancer therapies [13,14]. Along this line, there is now growing evidence that certain immune cells infiltrate into the tumors of human samples of lung cancer [12,[15][16][17][18][19]. However, to the best of our knowledge, the identification and quantification of several immune cell populations and their correlation to lung cancer type, stage and nodal status has not been reported.…”

Section: Introductionmentioning

confidence: 99%

Immune and Inflammatory Cell Composition of Human Lung Cancer Stroma

et al. 2015

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Recent studies indicate that the abnormal microenvironment of tumors may play a critical role in carcinogenesis, including lung cancer. We comprehensively assessed the number of stromal cells, especially immune/inflammatory cells, in lung cancer and evaluated their infiltration in cancers of different stages, types and metastatic characteristics potential. Immunohistochemical analysis of lung cancer tissue arrays containing normal and lung cancer sections was performed. This analysis was combined with cyto-/histomorphological assessment and quantification of cells to classify/subclassify tumors accurately and to perform a high throughput analysis of stromal cell composition in different types of lung cancer. In human lung cancer sections we observed a significant elevation/infiltration of total-T lymphocytes (CD3 ) compared with healthy donor specimens. We observed all of these immune cell markers in different types of lung cancers including squamous cell carcinoma, adenocarcinoma, adenosquamous cell carcinoma, small cell carcinoma, papillary adenocarcinoma, metastatic adenocarcinoma, and bronchioloalveolar carcinoma. The numbers of all tumor-associated immune cells (except MUM1 + cells) in stage III cancer specimens was significantly greater than those in stage I samples. We observed substantial stage-dependent immune cell infiltration in human lung tumors suggesting that the tumor microenvironment plays a critical role during lung carcinogenesis. Strategies for therapeutic interference with lung cancer microenvironment should consider the complexity of its immune cell composition.

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Tumor infiltrating lymphocytes and macrophages have a potential dual role in lung cancer by supporting both host-defense and tumor progression

Cited by 159 publications

References 33 publications

Macrophages promote angiogenesis in human breast tumour spheroids in vivo

Macrophages promote angiogenesis in human breast tumour spheroids in vivo

The possible role of matrix metalloproteinase (MMP)-2 and MMP-9 in cancer, e.g. acute leukemia

Immune and Inflammatory Cell Composition of Human Lung Cancer Stroma

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