Tumor-infiltrating lymphocytes predict cutaneous melanoma survival

Fortes, Cristina; Mastroeni, Simona; Mannooranparampil, Thomas J.; Passarelli, Francesca; Zappalà, Alba; Annessi, Giorgio; Marino, Claudia; Caggiati, Alessio; Russo, Nicoletta; Michelozzi, Paola

doi:10.1097/cmr.0000000000000164

Cited by 66 publications

(39 citation statements)

References 23 publications

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“…TILs are the major type of infiltrating immune cells and are represented by T cells, B cells, and natural killer cells 18. TILs are considered a manifestation of the host immune response against tumor cells, and several studies have already reported the potential of TILs as prognostic parameters in various human malignancies 18,20,38,39. So far, there are several methods to assess tumor immune response through lymphocytic infiltrations on formalin-fixed paraffin-embedded sections, such as morphologic evaluation of TILs,20 immunoscoring of T-cell subpopulations (eg, CD3 + or CD8 + ),40 and immunophenotyping 41.…”

Section: Discussionmentioning

confidence: 99%

“…In our study, only the morphologic evaluation of TILs is performed. It is demonstrated that a high density of TILs is recognized as a good prognostic marker in multiple malignancies 16,18,20,39. Thus, the morphologic evaluation of TILs, which is simple and could be assessed in routine clinical practice without extra cost, may help the doctors to quickly identify patients at high risk of recurrence and early death.…”

Section: Discussionmentioning

confidence: 99%

“…The favorable prognostic role of abundant TILs has been explored in several tumors 18,20,38,39. Vassilakopoulou et al20 reported that increased TILs density was associated with favorable outcome in LSCC.…”

Section: Discussionmentioning

confidence: 99%

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The prognostic value of systemic and local inﬂammation in patients with laryngeal squamous cell carcinoma

Wang¹,

Wang²,

Song³

et al. 2016

OTT

104

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BackgroundCancer-related systemic inflammation has been demonstrated to be associated with poor outcome in multiple types of cancers. Meanwhile, the local inflammation, which is characterized by dense intratumoral immune infiltrate, is a favorable predictor of survival outcome.PurposeTo evaluate the role of systemic and local inflammation in predicting outcome in patients with laryngeal squamous cell carcinoma.Patients and methodsIn this retrospective study, 120 patients who had undergone postoperative radiotherapy were enrolled. Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR), as calculated from pretreatment whole blood counts, were used to indicate systemic inflammation. The optimal cutoff values of NLR and PLR were determined using receiver operating characteristic curve analysis. Tumor infiltrating lymphocytes (TILs) density, as assessed by pathologist review of hematoxylin and eosin-stained slides, was used to represent local inflammation. Overall survival (OS) and recurrence-free survival (RFS) were assessed using the Kaplan–Meier method and multivariate Cox regression analysis.ResultsThe best cutoff was 2.79 for NLR and 112 for PLR. Kaplan–Meier analysis revealed that high NLR, high PLR, and low TILs density were significantly correlated with inferior OS and RFS, respectively (all P<0.05). The Cox proportional multivariate hazard model showed that a high pretreatment PLR and a low TILs density were both independently correlated with poor OS and RFS, respectively (all P<0.05).ConclusionMarkers of systemic and local inflammation, especially PLR and TILs density, are reliable prognostic factors in patients with laryngeal squamous cell carcinoma.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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The prognostic value of systemic and local inﬂammation in patients with laryngeal squamous cell carcinoma

Wang¹,

Wang²,

Song³

et al. 2016

OTT

104

View full text Add to dashboard Cite

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“…Tumor-infiltrating lymphocytes (TILs) are important immune cells found within tumors and are responsible for antitumor immune responses [37]. High numbers of TILs correlate with favorable clinical outcomes [38, 39]. In HCC patients, high levels of tumor-infiltrating CD4+ T lymphocytes are associated with a lower recurrence rate and better prognosis [40].…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological and prognostic significance of platelet-to-lymphocyte ratio in patients with hepatocellular carcinoma

et al. 2016

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The platelet-to-lymphocyte ratio (PLR) is reported to be a prognostic factor in multiple malignancies. The aim of this study was to assess its prognostic value in hepatocellular carcinoma (HCC). We performed comprehensive searches of electronic databases for relevant studies. A total of eleven studies comprising 2,507 patients were included. Elevated PLR was significantly associated with poor overall survival (OS) (HR = 1.78; 95% CI = 1.36-2.34; P < 0.001) and disease-free survival (DFS)/recurrence-free survival (RFS) (HR = 1.82; 95% CI = 1.56-2.13; P < 0.001). The findings from most subgroup analyses were consistent with those from the overall analysis. In addition, a high PLR correlated with tumor size > 3 cm, TNM stage, lymph node metastasis, distant metastasis, and vascular invasion. We therefore conclude that elevated pretreatment PLR may be predicative of a poor prognosis in patients with HCC.

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“…This has resulted in an uncertain prognosis for patients receiving the treatment. This uncertainty was addressed in a recent study of a large series of patients, in which it was observed that marked accumulation of TILs was a favorable prognostic factor [12]. Also, in a study sponsored by The Cancer Genome Atlas project, cutaneous melanoma patients with a higher lymphocyte score (LS) had longer overall survival than patients with a lower LS, regardless of the histological subtype [13].…”

Section: Introductionmentioning

confidence: 99%

Clinicopathological significance of intratumoral and peritumoral lymphocytes and lymphocyte score based on the histologic subtypes of cutaneous melanoma

Park

Kim

2017

Oncotarget

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The presence of tumor infiltrating lymphocytes is a favorable prognostic factor in cutaneous melanoma, but their clinicopathological significance in the intratumoral compartment compared to the peritumoral compartment is unclear. We investigated the clinicopathologic significance of tumor-infiltrating lymphocytes and lymphocyte score in intra- and peritumoral compartments in 177 Korean patients who had undergone surgical excision of cutaneous melanoma. No significant correlation was observed between various clinicopathologic factors and the presence of intratumoral lymphocytes. However, high peritumoral lymphocyte scores were associated with lower Clark levels (P = 0.001), shallower Breslow thicknesses (P = 0.006), and fewer mitotic counts (P = 0.01) than tumors with lower scores. There was a trend for longer disease-free survival in cases with peritumoral lymphocytes (P = 0.07) than those without peritumoral lymphocytes. In patients with acral lentiginous melanoma, a strong association between a high peritumoral lymphocyte score and shallow Clark level was apparent (P = 0.03), and the presence of peritumoral lymphocytes (P = 0.02) and a high intratumoral lymphocyte score (P = 0.04) was also associated with longer disease-free survival. Particularly, low intratumoral lymphocyte score remarkably affected tumor recurrence and distant metastasis in a multivariate analysis using Cox regression test (H.R. = 0.304, 95% C.I. = 0.078–1.185, P = 0.09). Thus, the presence of lymphocytes and high lymphocyte scores in the intratumoral and peritumoral compartments are valid prognostic factors in cutaneous melanoma.

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Tumor-infiltrating lymphocytes predict cutaneous melanoma survival

Cited by 66 publications

References 23 publications

The prognostic value of systemic and local inﬂammation in patients with laryngeal squamous cell carcinoma

The prognostic value of systemic and local inﬂammation in patients with laryngeal squamous cell carcinoma

Clinicopathological and prognostic significance of platelet-to-lymphocyte ratio in patients with hepatocellular carcinoma

Clinicopathological significance of intratumoral and peritumoral lymphocytes and lymphocyte score based on the histologic subtypes of cutaneous melanoma

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