Tumor inhibitors. LXIV. isolation and structural elucidation of novel bufadienolides, the cytotoxic principles of Bersama abyssinica

Kupchan, S. Morris; Ognyanov, I.; Moniot, Jerry L.

doi:10.1016/0045-2068(71)90003-4

Cited by 28 publications

(36 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…B. abyssinica was reported to be traditionally used for treating patients with malignancies [4]. Later studies revealed that bufadienolides isolated from the alcoholic extract of B. abyssinica showed cytotoxic activity [5]. Hellebrigenin 3-acetate (I) and hellebrigenin 3,5-diacetate (II), isolated from B. abyssinica alcoholic stem bark extracts, showed cytotoxic activity against human nasopharynx cancer cells [6].…”

Section: Introductionmentioning

confidence: 99%

Biopotential of Bersama abyssinica Fresen Stem Bark Extracts: UHPLC Profiles, Antioxidant, Enzyme Inhibitory, and Antiproliferative Propensities

et al. 2020

View full text Add to dashboard Cite

In this study, ethyl acetate, methanol, and water extracts of Bersama abyssinica (Melianthaceae) stem bark were screened for enzyme inhibitory and antioxidant properties. The water extract possessed the highest concentration of phenols (230.83 mg gallic acid equivalent/g extract), while the methanol extract was rich in flavonoids (75.82 mg rutin equivalent/g extract), and the ethyl acetate extract possessed the highest amount of saponins (97.37 mg quillaja equivalent/g). The aim of this study was to investigate the antiproliferative effects against the human colon cancer HCT116 cell line challenged with serotonin (5-HT) as a stimulating-proliferation factor. The level of HCT116 cell-deriving pool of kynurenic acid (KA) was also assessed. The UHPLC results confirmed the presence of 58, 68, and 63 compounds in the ethyl acetate, methanol, and water extracts, respectively. Mangiferin, vitexin and its isomer isovitexin were tentatively identified in all extracts and KA (m/z 190.05042 [M−H] + ) was also tentatively identified in the methanol and water extracts. The methanol extract (1464.08 mg Trolox equivalent [TE]/g extract) showed the highest activity in the CUPRAC assay, whereas the water extract (1063.70 mg TE/g extract) showed the highest activity with the FRAP technique. The ethyl acetate extract was the most active acetylcholinesterase (4.43 mg galantamine equivalent/g extract) and α-glucosidase (mmol acarbose equivalent /g extract) inhibitor. The water extract was able to inhibit 5-HT-stimulated viability of HCT116 cells, and blunt 5-HT-induced reduction of cell-deriving KA. The scientific data generated in this study provide baseline data regarding the biological properties of B. abyssinica stem bark, highlighting its potential use for the development of new pharmaceutic and cosmetic agents.

show abstract

Section: Introductionmentioning

confidence: 99%

Biopotential of Bersama abyssinica Fresen Stem Bark Extracts: UHPLC Profiles, Antioxidant, Enzyme Inhibitory, and Antiproliferative Propensities

et al. 2020

View full text Add to dashboard Cite

show abstract

“…The extract exhibited total Maroyi growth inhibition values of 1.1 µg/ml against ovarian (OVCAR-3), 1.4 µg/ml against central nervous system cancer, CNSC SF-539 and 1.4 µg/ml against non-small cell lung cancer, NSCLC A549/ATCC [81]. The documented anticancer activities may be attributed to bufadienolides as these compounds are known to have anticancer activities [62][63][64][65][66][67][68].…”

Section: Anticancer Activitiesmentioning

confidence: 98%

“…Van et al [61] argued that there is a danger of accidental poisoning or that people may be harmed if bulbs of D. elata are used indiscriminately as rubbing the bulb scales or leaves on bare skin produces a stinging and irritating effect and a skin rash is produced. However, bufadienolides are known to have a wide range of biological activities including anti-tumor, antiproliferative, and cytotoxic activities [62][63][64][65][66][67][68].…”

Section: Phytochemical Constituents Of D Elatamentioning

confidence: 99%

Review of Medicinal Uses, Phytochemistry, and Pharmacological Properties of Drimia Elata

Maroyi

2019

Asian J Pharm Clin Res

View full text Add to dashboard Cite

Drimia elata is an important and well-known medicinal plant in tropical Africa. This study critically reviewed the medicinal applications, phytochemistry, and pharmacological activities of D. elata. Literature on medicinal applications, phytochemical, and pharmacological activities of D. elata was collected from multiple internet sources including Elsevier, Google Scholar, SciFinder, Web of Science, PubMed, BMC, ScienceDirect, and Scopus. Complementary information was gathered from pre-electronic sources such as books, book chapters, theses, scientific reports, and journal articles obtained from the university library. This study showed that D. elata is used for treating several medical conditions, particularly general ailments, blood and cardiovascular system, reproductive system and sexual health, urinary system, infections and infestations, digestive system, respiratory system, and muscular-skeletal system disorders. Phytochemical compounds identified from the species include bufadienolides, alkaloids, aromatic acids, flavonoids, phlobatannins, saponins, steroids, tannins, and terpenoids. Ethnopharmacological research revealed that D. elata extracts have acetylcholinesterase enzyme inhibitory, antibacterial, antifungal, antimycobaceterial, anticancer, anti-inflammatory, antioxidant, hemagglutinating, and cytotoxicity activities. D. elata should be subjected to extensive in vivo experiments and also future studies should focus on how potential toxic components of the species can be managed when it is used as herbal medicine.

show abstract

“…In a further search for insecticidal compounds from Indonesian Kalanchoe (syn. Bryophyllum) species, we found that the methanolic extract of K. daigremontiana x tubiflora produced three insecticidal bufadienolides, bersaldegenin-1,3,5-orthoacetate (5), daigremontianin (6), and methyl daigremonate (9), together with an inactive bufadienolide, bersaldegenin-1-acetate (8) ( Figure 1) [7].…”

mentioning

confidence: 99%

Synthetic and Structure-Activity Relationship of Insecticidal Bufadienolides

Hidayat

Zainuddin

Dono

et al. 2014

Natural Product Communications

View full text Add to dashboard Cite

A new synthetic analog of bufadienolide, methyl isobryophyllinate A (1), and a known synthetic analog, methyl isobersaldegenate-1,3,5-orthoacetate (2), were obtained by methanolysis of bryophyllin A (3) and bersaldegenin-1,3,5-orthoacetate (5) in basic solution. Structure-insecticidal activity relationship studies revealed both orthoacetate and -pyrone moieties seemed to be essential structural elements for exhibiting insecticidal activity, whereas oxygenated substituents in the C ring enhanced the insecticidal activity against the third instar larvae of silkworm (Bombyx mori).

show abstract

Tumor inhibitors. LXIV. isolation and structural elucidation of novel bufadienolides, the cytotoxic principles of Bersama abyssinica

Cited by 28 publications

References 25 publications

Biopotential of Bersama abyssinica Fresen Stem Bark Extracts: UHPLC Profiles, Antioxidant, Enzyme Inhibitory, and Antiproliferative Propensities

Biopotential of Bersama abyssinica Fresen Stem Bark Extracts: UHPLC Profiles, Antioxidant, Enzyme Inhibitory, and Antiproliferative Propensities

Review of Medicinal Uses, Phytochemistry, and Pharmacological Properties of Drimia Elata

Synthetic and Structure-Activity Relationship of Insecticidal Bufadienolides

Contact Info

Product

Resources

About