Tumor-inhibitory and liver-protective effects of Phellinus igniarius extracellular polysaccharides

Wang, Dong; Li, Ning; Lu, Wenjin; CuiCui, Li; Chen, Rui-peng; Jia, Xiao-ning; Lin, Wen‐Lang; Guo, Leilei

doi:10.1007/s11274-009-9967-8

Cited by 19 publications

(7 citation statements)

References 16 publications

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“…In this study, we demonstrated that the implantation with S180 sarcoma to mice lead to a marked elevation in the levels of serum AST, ALT and ALP which is indicative of hepatocellular damage, as previously reported [ 32 ]. This elevation could potentially be attributed to the release of these enzymes from the cytoplasm into the blood circulation after rupture of the plasma membrane and cellular damage.…”

Section: Discussionsupporting

confidence: 86%

Effect of Tea Polyphenol on Oxidative Injury in S180 Cells Induced Hepatocarcinoma Mice

Cui

Liu

et al. 2012

IJMS

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The purpose of this study was to evaluate the antioxidant nature of tea polyphenol on S180 cells induced liver cancer in mice. In the present study, hepatocellular carcinoma was induced by tumor transplantation of liver in situ. The antitumor activity of tea polyphenol has been determined in vivo in hepatocellular carcinoma mice after treatment of drug (50, 100, 150 mg/kg body weight) by gavage for 20 days. Results showed that a significant increase in serum aspartate transaminase (AST), alkaline phosphatase (ALP), alanine aminotransfere (ALT), malondialdehyde (MDA) level, decrease in serum white blood cells (WBC), serum total protein (TP), albumin (ALB), A/G, tumor necrosis factor-α (TNF-α) and interferon-gamma (IFN-γ), liver reduced glutathione (GSH) levels were observed. In addition, the levels of enzymic and non-enzymic antioxidants were decreased when subjected to S180 cells induction. These altered enzyme levels were ameliorated significantly by administration of tea polyphenol at the concentration of 50, 100, 150 mg/kg body weight in drug-treated animals. These results indicate that the protective effect of tea polyphenol was associated with inhibition of MDA induced by S180 cells and to maintain the antioxidant enzyme levels.

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Section: Discussionsupporting

confidence: 86%

Effect of Tea Polyphenol on Oxidative Injury in S180 Cells Induced Hepatocarcinoma Mice

Cui

Liu

et al. 2012

IJMS

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“…The ethanolic extract from the fruiting body of P. igniarius showed antiproliferative and antimetastatic effects in human hepatocarcinoma (SK-Hep-1) and rat heart vascular endothelial Polysaccharides from soybeans fermented with P. igniarius showed inhibitory effects on carcinogenesis and pulmonary inflammation [30]. It was also shown that crude extracellular polysaccharides from P. igniarius when used to treat S180 sarcoma and H22 hepatoma inhibited tumor growth and protected the liver without toxic effects [31]. Kang and others [32] reported that a butanol extract of P. igniarius induces endothelium-dependent vasorelaxation of isolated rat aorta.…”

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confidence: 99%

Phellinus igniarius: A Pharmacologically Active Polypore Mushroom

Zapora

Wołkowycki

Бакиер

et al. 2016

Natural Product Communications

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Mushrooms have been widely used in traditional medicine for the treatment of various diseases. Today, their therapeutic value is scientifically studied and appreciated. Research indicates that polypores-a large group of fungi of the phylum Basdiomycota-exhibit antiviral, antimicrobial, anticancer, anti-allergic, anti-atherogenic, hypoglycemic, hepatoprotective and anti-inflammatory activities. Phellinus igniarius, a polypore mushroom, is one of the most used in traditional Asian medicine. Its potent anticancer activity has been repeatedly reported. In the past two decades, numerous pharmacologically active metabolites have been isolated and identified from P. igniarius. Among the large number of compounds, the most active group are polysaccharides. They modulate immune responses and inhibit tumor growth.

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“…Similar blood cholesterol and triglyceride reducing effect of green tea has been reported by others also (Imai and Nakachi [38]; Yang and Koou [39]). The levels of liver enzymes such as ALP, ALT and ALP were increased in EAC bearing mice (group II) compared with normal mice (group I) which indicate hepatocellular damage [40]. However, pre-and post-treatment of EAC bearing mice with TPP-SLN (groups IV and VI) decreased the levels of these liver enzymes.…”

Section: Resultsmentioning

confidence: 88%

“…The levels of liver enzymes such as ALP, ALT and ALP were increased in EAC bearing mice (group II) compared with normal mice (group I) which indicate hepatocellular damage [40]. However, pre‐ and post‐treatment of EAC bearing mice with TPP‐SLN (groups IV and VI) decreased the levels of these liver enzymes.…”

Section: Resultsmentioning

confidence: 99%

Positive regulation of biochemical parameters by tea polyphenol encapsulated solid lipid nanoparticles at in vitro and in vivo conditions

Karikalan

Mandal

2016

IET nanobiotechnol.

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Tea polyphenols (TPPs) comprise preventive and therapeutic potentials against cancer, cardiovascular and neurological disorders. Chemical instability of TPP which leads to low bioavailability is the major constrain to its use as therapeutic agent. The authors prepared TPP encapsulated solid lipid nanoparticles (TPP-SLNs) to increase its stability and bioefficacy. Comparison of Fourier transformed infrared spectra of unloaded SLN, free TPP and TPP-SLN indicated encapsulation of TPP. Sustained release of TPP from TP-SLN was observed. TPP-SLN showed prolonged free radical scavenging activity compared with free TPP indicating protection of TPP. TPP-SLN showed activation of Caspases-9 and -3 cascades in breast cancer cell line (Michigan cancer foundation (MCF)-7) at conditions. Biochemical parameters were altered in Ehrlich ascetic carcinoma (EAC) cell bearing mice compared with normal (uninduced) mice which were ameliorated significantly by oral feeding of TPP-SLN. Oral administration (pre- and post-treated) of TPP-SLN in EAC bearing mice resulted in significant increase of plasma haemoglobin, glucose, superoxide dismutase and catalase when compared with EAC bearing control mice. Other biochemical parameters (cholesterol, bilirubin, triglyceride, urea, total protein, alanine aminotransferase, alkaline phosphatase and aspertate transaminase were significantly decreased on oral administration (pre- and post-treated) of TPP-SLN in EAC bearing mice.

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Tumor-inhibitory and liver-protective effects of Phellinus igniarius extracellular polysaccharides

Cited by 19 publications

References 16 publications

Effect of Tea Polyphenol on Oxidative Injury in S180 Cells Induced Hepatocarcinoma Mice

Effect of Tea Polyphenol on Oxidative Injury in S180 Cells Induced Hepatocarcinoma Mice

Phellinus igniarius: A Pharmacologically Active Polypore Mushroom

Positive regulation of biochemical parameters by tea polyphenol encapsulated solid lipid nanoparticles at in vitro and in vivo conditions

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