Tumor invasiveness as defined by the newly proposed IASLC/ATS/ERS classification has prognostic significance for pathologic stage IA lung adenocarcinoma and can be predicted by radiologic parameters

Abstract

We found that by using the new IASLC/ATS/ERS classification, histologic subtypes of pathologic stage IA lung adenocarcinoma with prognostic value could be identified. Tumor invasiveness of lung adenocarcinoma as defined by this classification can be predicted by evaluating the ground-glass opacity ratio, tumor disappearance rate, and consolidation diameter on thin-section computed tomography.

Prognostic Role of Subtype Classification in Small-Sized Pathologic N0 Invasive Lung Adenocarcinoma

“…Many studies of lung adenocarcinoma subtypes have confirmed the prognostic value of subtype classification for disease-free survival and overall survival [11,[19][20][21][22][23][24][25][26]. Patients with adenocarcinoma in situ and minimally invasive adenocarcinoma have a 5-year disease-specific survival rate of 100%, followed by lepidic-predominant invasive adenocarcinoma, for which disease-specific survival is nearly 100%.…”

Correlation in histological subtypes with high resolution computed tomography signatures of early stage lung adenocarcinoma

“…Previous studies have explored CT features correlating with pathological invasiveness. They reported that tumors with higher solid volume proportion and larger diameter indicated IA rather than non-invasive lesions (AIS and MIA) (10)(11)(12). Nevertheless, uncertainty remains on the correlation between image characteristics of the nodules in CT scans and adenocarcinoma histopathologic subtypes.…”

The effectiveness of mediastinal lymph node evaluation in a patient with ground glass opacity tumor

“…The persistent presence of GGO nodules on CT usually suggests the presence of lung adenocarcinoma or a precancerous lesion (2). Since GGO tumor is considered to have a lepidic pattern, which is noninvasive in many cases, a tumor with more GGO content generally has a better prognosis (3)(4)(5). Since adenocarcinoma with GGO features may have a variety of prognoses due to amount of heterogeneity, options for surgical treatment (limited resection versus standard anatomical resection) is often selected depending on the degree of GGO.…”