Tumor Lysis-like Syndrome in Eosinophilic Disease of the Lung: A Case Report and Review of the Literature

Abstract

Tumor lysis syndrome (TLS) is a metabolic disorder that is generally associated with a malignancy leading to hyperuricemia, hyperphosphatemia, and acute kidney injury. On the other hand, we sometimes encounter these phenomena in nonmalignant disease, which has been referred to as tumor lysis-like syndrome in some studies. We herein experienced a case in which tumor lysis-like syndrome occurred in the course of therapy for eosinophilic disease of the lung, a nonmalignant disease. Even in nonmalignant disease, massive cell lysis induced by therapy can cause phenomena such as TLS or tumor lysis-like syndrome.

Síndrome de lisis tumoral secundario a la administración de corticoides en una adolescente sin enfermedad neoplásica confirmada: reporte de un caso

“…Al no detectar enfermedad maligna evidente, entre los diagnósticos diferenciales se deben considerar enfermedades no malignas, que puedan tener una presentación clínica y de laboratorio similar al SLT (denominado símil SLT), como leishmaniosis visceral, enfermedad de Castleman, histiocitosis d e c é l u l a s d e L a n g e r h a n s , h e m a n g i o m a infantil, mielopoyesis anormal transitoria y mielodisplasia. 11 Todas estas patologías fueron descartadas en la paciente descripta.…”