Tumor lysis syndrome in a patient with metastatic non-small cell lung cancer: Case report and literature review

Myint, Zaw; Verla-Tebit, Emaculate; Cho, Benjamin B.; Goodner, Sherry A.; Stelow, Edward B.; Weiss, Geoffrey R.; Fracasso, Paula M.

doi:10.1016/j.ctrc.2015.03.002

Cited by 5 publications

(4 citation statements)

References 24 publications

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“…There have been reports of TLS as a post-treatment complication in cases of colon cancer [17,18], lung cancer [19], breast cancer [20], and pancreatic cancer [21]. Notably, Patel et al described a case of spontaneous TLS leading to AKI in a patient with non-Hodgkin's lymphoma [22].…”

Section: Discussionmentioning

confidence: 99%

Acute gouty arthritis following percutaneous cryoablation of renal cell carcinoma

Mohamed

Wallach

et al. 2019

Radiology Case Reports

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We report a case of acute gouty monoarthritis of the left ankle in a 58-year-old female with chronic renal insufficiency after cryoablation of a 3.8 cm left renal cell carcinoma. The patient's symptoms resolved after intravenous Solumedrol and did not recur at her 1-month follow-up visit. To the best of our knowledge, this is the first reported case of acute gouty monoarthritis after cryoablation of a renal cell carcinoma lesion in a patient with underlying chronic renal insufficiency. Clinicians should be vigilant of the potential for this complication in at-risk patient populations.

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Section: Discussionmentioning

confidence: 99%

Acute gouty arthritis following percutaneous cryoablation of renal cell carcinoma

Mohamed

Wallach

et al. 2019

Radiology Case Reports

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“…This case represents the 11th report of TLS in nonsmall cell lung cancer. It is a rare report of TLS after surgical resection and first associated with bronchial carcinoid tumor [2,3]. Prior cases of TLS in NSCLC have been associated with chemotherapy and radiotherapy, as well as spontaneous occurrences without a known trigger.…”

Section: Commentmentioning

confidence: 99%

Tumor Lysis Syndrome After Bilobectomy for Typical Carcinoid Tumor of the Lung

Shin

Inagaki

Ganta

et al. 2019

The Annals of Thoracic Surgery

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Tumor lysis syndrome (TLS) is a life-threatening complication comprised of hyperuricemia, hyperkalemia, hyperphosphatemia, and hypocalcemia attributed to release of intracellular contents. While traditionally associated with leukemia and lymphoma after chemotherapy, it is known to occur in solid malignancies. We herein report a rare case of this syndrome after resection of bulky carcinoid tumor of the lung.

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“…TLS mostly develops in the context of haematologic malignancies and is relatively rare in solid tumours (Cairo et al, 2010). Only a few cases of TLS have been reported in non-small cell lung cancer (NSCLC), most of which are induced by chemotherapy (Myint et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Fatal Tumour Lysis Syndrome Induced by Brigatinib in a Lung Adenocarcinoma Patient Treated With Sequential ALK Inhibitors: A Case Report

Wang¹,

Wang²,

Jia³

et al. 2021

Front. Pharmacol.

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Tumour lysis syndrome (TLS) represents a group of fatal metabolic derangements resulting from the rapid breakdown of tumour cells. TLS typically occurs soon after the administration of chemotherapy in haematologic malignancies but is rarely observed in solid tumours. Here, we report a case of brigatinib-induced TLS after treatment with sequential anaplastic lymphoma kinase (ALK) inhibitors in a patient with advanced ALK-rearranged lung adenocarcinoma. The patient was treated sequentially with crizotinib, alectinib, and ensartinib. High-throughput molecular profiling after disease progression indicated that brigatinib may overcome ALK resistance mutations, so the patient was administered brigatinib as the fourth-line treatment. After 22 days of therapy, he developed oliguria, fever, and progressive dyspnoea. Clinical manifestations and laboratory findings met the diagnostic criteria for TLS. The significant decrease in the abundance of ALK mutations in plasma indicated a therapeutic response at the molecular level. Consequently, the diagnosis of brigatinib-induced TLS was established. To the best of our knowledge, this is the first case of TLS induced by sequential targeted therapy in non-small cell lung cancer. With the extensive application of sequential therapy with more potent next-generation targeted therapeutic drugs, special attention should be given to this rare but severe complication.

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Tumor lysis syndrome in a patient with metastatic non-small cell lung cancer: Case report and literature review

Cited by 5 publications

References 24 publications

Acute gouty arthritis following percutaneous cryoablation of renal cell carcinoma

Acute gouty arthritis following percutaneous cryoablation of renal cell carcinoma

Tumor Lysis Syndrome After Bilobectomy for Typical Carcinoid Tumor of the Lung

Fatal Tumour Lysis Syndrome Induced by Brigatinib in a Lung Adenocarcinoma Patient Treated With Sequential ALK Inhibitors: A Case Report

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